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Supplemental Information

Supplemental Information 1

DOI: 10.7287/peerj.preprints.102v1/supp-1

Supplemental Information 2

DOI: 10.7287/peerj.preprints.102v1/supp-2

Supplemental Information 3

DOI: 10.7287/peerj.preprints.102v1/supp-3

Supplemental Information 4

DOI: 10.7287/peerj.preprints.102v1/supp-4

Supplemental Information 5

DOI: 10.7287/peerj.preprints.102v1/supp-5

Additional Information

Competing Interests

There are no competing interests.

Author Contributions

Xundou Li conceived and designed the experiments, performed the experiments, analyzed the data, wrote the paper.

Mindi Zhao performed the experiments.

Menglin Li mS analysis.

Lulu Jia contributed reagents/materials/analysis tools.

Youhe Gao conceived and designed the experiments.

Animal Ethics

The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):

This study was approved by the Institute of Basic Medical Sciences Animal Ethics

Committee, Peking Union Medical College (Animal Welfare Assurance Number: # A5518).

Specific pathogen-free male Sprague-Dawley rats (150-160 g) were purchased from the Institute

Of Laboratory Animal Science, Chinese Academy of Medical Science.


This work was supported by the National Basic Research Program of China (2012CB517606, 2013CB530805, 2011CB964901), the National High Technology Research and Development Program of China (2011AA020116), Program for Changjiang Scholars and Innovative Research Team in University-PCSIRT (IRT0909), and 111 Project(B08007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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