Preprints (not yet peer-reviewed)

303 downloads
1,268 views

Sufficient quantities of cells of consistent characteristics are needed for studying biologicalprocesses (at the population level ) in many areas of applied microbiology. However, generating the requisite biomass by cell culture is usually the rate-limiting step...

["Biochemistry","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.115v6
23 downloads
184 views

Conservation biological control emphasizes the importance of vegetation other than the focal crop for providing natural enemies with refuge and shelter against disturbance. There is an unmet need for better methods to identify types of vegetation that are optimal...

["Agricultural Science","Biodiversity","Ecology","Ecosystem Science"]
doi:10.7287/peerj.preprints.3003v1
44 downloads
118 views

Many applications require the calculation of site-specific evolutionary rates from alignments of amino-acid sequences. For example, catalytic residues in enzymes and interface regions in protein complexes can be inferred from observed relative rates. While numerous...

["Bioinformatics","Evolutionary Studies","Mathematical Biology"]
doi:10.7287/peerj.preprints.3002v1
7 downloads
99 views

Live attenuated viral vaccines provide the most robust and longest lasting immune response. Yet designing them a priori to have reduced growth capacity and also to be robust to evolutionary reversion can be challenging. On the one hand, genome editing methods now...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.3001v1
135 downloads
500 views

Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems in species complexes and rapid radiations....

["Bioinformatics","Evolutionary Studies","Plant Science"]
doi:10.7287/peerj.preprints.2763v3
100 downloads
274 views

Many species of birds react to climate change, for example, by wintering in areas closer to their breeding areas. We investigated the responses of two different functional groups of waterbirds to factors associated with climate change. The Odra River Estuary (SW...

["Ecology","Ecosystem Science","Zoology"]
doi:10.7287/peerj.preprints.2652v3
94 downloads
421 views

Despite most Spatial Data Infrastructures are offering service-based visualization of geospatial data, requirements are often at a very basic level leading to poor quality of maps. This is a general observation for any geospatial architecture as soon as open standards...

["Spatial and Geographic Information Systems","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.2415v3
15 downloads
149 views

Influenza A viruses cause an annual highly contagious respiratory disease in humans, and are responsible for periodic human pandemics that have high mortality rates. Pandemic influenza A viruses can result from reassortment of one or more gene segments between...

["Evolutionary Studies","Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.3000v1
9 downloads
237 views

BACKGROUND: 2’-4’ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2947v2
21 downloads
90 views

The desert bighorn sheep is adapted to the extreme conditions of arid ecosystems. The amount and distribution of watering holes is an essential component of the habitat of this species. With information provided by people in Sierra Santa Isabel a database of potential...

["Animal Behavior","Conservation Biology","Ecology"]
doi:10.7287/peerj.preprints.2999v1
25 downloads
45 views

Advanced Persistent Threat (APT) is one of the most serious types of cyber attacks, which is a new and more complex version of multi-step attack. Within the APT life cycle, the most common technique used to get the point of entry is spear-phishing emails which...

["Computer Networks and Communications","Security and Privacy"]
doi:10.7287/peerj.preprints.2998v1
48 downloads
171 views

Avian malaria parasites (genera Haemoproteus, Plasmodium, and Leucocytozoon) affect bird demography, distribution limits, and community structure, yet most bird communities and populations remain unsurveyed. We conducted a community-level survey of these vector-transmitted...

["Biodiversity","Parasitology","Zoology"]
doi:10.7287/peerj.preprints.2997v1
248 downloads
1,081 views

Environmental bulk samples often contain many taxa that vary several orders of magnitude in biomass. This can be problematic in DNA metabarcoding and metagenomic high-throughput sequencing approaches, as large specimens contribute disproportionately high amounts...

["Biodiversity","Conservation Biology","Environmental Sciences","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2561v3
24 downloads
86 views

Clinical bioinformatics is an emerging field in diagnostic genetics laboratories that are harnessing next-generation sequencing technologies to improve patient care. This document provides guidance for the development and validation of software used for delivery...

["Bioinformatics","Genomics","Science Policy"]
doi:10.7287/peerj.preprints.2996v1
85 downloads
349 views

Background: For more than 25 years the golden mussel Limnoperna fortunei has been an aggressive invader in South America freshwaters, having travelled more than 5,000 km upstream across 5 countries. The mussel has outcompeted native species in the invaded environments...

["Bioinformatics","Computational Biology","Conservation Biology","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2995v1
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