Preprints (not yet peer-reviewed)

32 downloads
98 views

Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature death amongst epilepsy patients. It is hypothesized to result from cardiorespiratory dysfunction, but the exact aetiology is unknown. The aim of this study was to determine if functional...

["Neuroscience","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.26999v1
397 downloads
921 views

Research products that lack transparency and are influenced by confirmation bias lead to barriers that, when left unchecked, propagate throughout the scientific record and lead to wasted research effort. Phylogenetics is particularly vulnerable given its ever-evolving...

["Evolutionary Studies","Ethical Issues"]
doi:10.7287/peerj.preprints.26585v3
43 downloads
120 views

This detailed analysis provides an insight into aging processes in the human organism. The developmental program that controls the regulation of gene expression through epigenetic modifications leads to cellular senescence in the latter life. This epigenetic development...

["Cell Biology","Developmental Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.26998v1
42 downloads
154 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, ribosome dissociates into...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.26997v1
83 downloads
243 views

Antibodies are proteins generated by the adaptive immune system to recognize and counteract a plethora of pathogens through specific binding. This adaptive binding is mediated by structural diversity in the six complementary determining region (CDR) loops (H1,...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.26996v1
28 downloads
170 views

Spurs are a testosterone-dependent secondary sexual characteristic of male chickens (Gallus gallus domesticus) and are used as ‘weapons’ in intra-sexual fighting. While predominantly a male feature, they are also found in a small number of females. Here we show...

["Agricultural Science","Animal Behavior","Zoology"]
doi:10.7287/peerj.preprints.26994v1
62 downloads
259 views

Oaks (Quercus) comprise more than 400 species worldwide and centres of diversity for most sections lie in the Americas and East/Southeast Asia. The only exception is the Eurasian Sect. Cerris that comprises 15 species, a dozen of which are confined to western Eurasia....

["Biodiversity","Biogeography","Evolutionary Studies","Plant Science","Taxonomy"]
doi:10.7287/peerj.preprints.26995v1
75 downloads
414 views

Human primary T cells are invaluable and feasible model systems to study the characteristics of the immune cells in various contexts, including but not limited to cancer immunotherapy. Following isolation of T cells from fresh human blood samples, it is possible...

["Cell Biology","Genetics","Molecular Biology","Immunology"]
doi:10.7287/peerj.preprints.26993v1
522 downloads
1,101 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
258 downloads
369 views

Advanced Persistent Threat (APT) is one of the most serious types of cyber attacks, which is a new and more complex version of multi-step attack. Within the APT life cycle, the most common technique used to get the point of entry is spear-phishing emails which...

["Computer Networks and Communications","Security and Privacy"]
doi:10.7287/peerj.preprints.2998v2
81 downloads
464 views

Background. To gain a greater insight into normal and laminitic hoof growth and to be able to make comparisons between the two groups. Methods. Ten normal and three laminitic equines completed the survey, each hoof was marked with a horizontal file mark in three...

["Biophysics","Veterinary Medicine"]
doi:10.7287/peerj.preprints.26992v1
172 downloads
255 views

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26991v1
105 downloads
280 views

Aggression is a serious behavioral disorder in domestic dogs that endangers both dogs and humans. The underlying causes of canine aggression are poorly resolved and require illumination to ensure effective therapy. Recent research links the compositional diversity...

["Animal Behavior","Bioinformatics","Microbiology"]
doi:10.7287/peerj.preprints.26990v1
23 downloads
91 views

Background. Phyllotreta striolata is a worldwide pest that harms cruciferous vegetables. The use of pathogenic microorganisms to control pests is an important means of biological control. Using pathogenic microorganisms to prevent and control P. striolata has rarely...

["Agricultural Science","Entomology","Mycology"]
doi:10.7287/peerj.preprints.26989v1
58 downloads
137 views

The study of how the observable features of organisms, i.e., their phenotypes, result from the complex interplay between genetics, development, and the environment, is central to much research in biology. The varied language used in the description of phenotypes,...

["Biodiversity","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.26988v1
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