Preprints (not yet peer-reviewed)

67 downloads
174 views

The Lung Imaging Data Consortium and Image Database Resource Initiative (LIDC) conducted a multi-site reader study that produced a comprehensive database of Computed Tomography (CT) scans for over 1000 subjects annotated by multiple expert readers. The result is...

["Bioinformatics","Oncology","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.27378v1
27 downloads
76 views

Explaining the variability in drug sensitivity across a panel of cell lines using genomic information is a key aspect of cancer drug discovery. The results of such analyses may ultimately determine which patients are likely to benefit from a new treatment. There...

["Bioinformatics","Computational Biology","Genomics","Drugs and Devices","Oncology"]
doi:10.7287/peerj.preprints.27345v1
48 downloads
130 views

The American FDA approved the first comprehensive NGS diagnostic assay for cancer at the end of 2017, leading the way to personalised therapy of cancer and the massive employ of bioinformatics (https://www.fda.gov/downloads/medicaldevices/productsandmedicalprocedures/invitrodiagnostics/...

["Oncology","Medical Genetics","Computational Science"]
doi:10.7287/peerj.preprints.27338v1
31 downloads
95 views

Background: HOXC6 is a member of the HOX gene family. The elevated expression of this gene occurs in prostate and breast cancers. However, the role of HOXC6 in esophageal squamous cell carcinoma (ESCC) remains largely uninvestigated.Methods: The expression of HOXC6...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.27324v1
166 downloads
286 views

Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of disease. Chromosomal amplifications have been identified as a source of upregulation of cervical cancer driver genes but cannot fully explain...

["Computational Biology","Microbiology","Oncology"]
doi:10.7287/peerj.preprints.26957v1
71 downloads
194 views

Background: We established a glioma biobank at Beijing Tiantan Hospital in November, 2010.Specialized staffs have been trained to collect, store and manage the biobank in accordance with standard operating procedures. Methods: One hundred samples were selected...

["Neurology","Oncology","Translational Medicine"]
doi:10.7287/peerj.preprints.3478v1
107 downloads
441 views

Background. The c-mos proto-oncogene was one of the first proto-oncogenes to be cloned. Apart from its role in meiosis, many efforts have been made to illuminate the mechanisms by which c-mos acts as an oncogene. c-mos or its coding messenger RNA have been confirmed...

["Cell Biology","Oncology"]
doi:10.7287/peerj.preprints.3426v1
146 downloads
513 views

Statistical significance provides evidence for or against an explanation of a population of interest, not a description of data sampled from the population. This simple distinction gets ignored in hundreds of thousands of research publications yearly, which confuse...

["Ecology","Evidence Based Medicine","Oncology","Statistics","Environmental Impacts"]
doi:10.7287/peerj.preprints.3394v1
72 downloads
223 views

While biochemistry evidently affects the growth rate of cells, many biochemists routinely ignore population variation, just like population geneticists usually ignore causal details of biochemistry that underpin a change in growth rate caused by a mutation. A true...

["Biochemistry","Cell Biology","Computational Biology","Oncology","Computational Science"]
doi:10.7287/peerj.preprints.3371v1
1,085 downloads
3,298 views

Exposure to non-ionizing radiation used in wireless communication remains a contentious topic in the public mind - while the overwhelming scientific evidence to date suggests that microwave and radio frequencies used in modern communications are safe, public apprehension...

["Biophysics","Environmental Sciences","Cognitive Disorders","Oncology","Science and Medical Education"]
doi:10.7287/peerj.preprints.3355v1
65 downloads
193 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
307 downloads
481 views

The mutational processes responsible for the somatic mutations observed in tumor samples can significantly vary not only between tumor types but also among the individual cancers within a tumor class. Mutational processes can be represented by so called “mutational...

["Bioinformatics","Computational Biology","Genomics","Oncology"]
doi:10.7287/peerj.preprints.3257v1
151 downloads
525 views

We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more...

["Cell Biology","Genomics","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.3146v1
62 downloads
421 views

Human papillomavirus type 16 (HPV16) is the most carcinogenic HPV, causing >50% of cervical cancers. Its unique oncogenicity is unsolved, e.g., the second most carcinogenic type (HPV18, causing ~16% of cancers) is relatively distantly related to HPV16. Mirabello...

["Bioinformatics","Evolutionary Studies","Infectious Diseases","Oncology","Women's Health"]
doi:10.7287/peerj.preprints.3070v1
125 downloads
418 views

Cancer development as an ecological and evolutionary process is poorly understood, which includes early cancer evolution, malignancy and metastasis. It was hypothesised that the tumour microenvironment (TME) plays a critical role in this process. Unfortunately,...

["Computational Biology","Ecology","Evolutionary Studies","Genetics","Oncology"]
doi:10.7287/peerj.preprints.3052v1
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