Preprints (not yet peer-reviewed)

13 downloads
110 views

Background. Enteroviruses are small non-enveloped viruses with (+) ssRNA genome with one open reading frame. Enterovirus protein 3C (or 3CD for some species) binds the replicative element oriL to initiate replication. The replication of enteroviruses features low...

["Evolutionary Studies","Genomics","Virology"]
doi:10.7287/peerj.preprints.3153v2
6 downloads
52 views

Microfluidic cell culture chambers have enabled the isolation, culture and growth of various species of microorganisms and human cells. However, based on elastomers such as poly(dimethyl siloxane) (PDMS), these culture devices are not readily amenable to imaging...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.3245v1
272 downloads
1,090 views

For long-term persistence of species, population structure is important. Traits that hold adaptive advantage such as reproductive timing and stress resilience may differ among locales. Knowledge and consideration of these traits should be integrated into conservation...

["Aquaculture, Fisheries and Fish Science","Conservation Biology"]
doi:10.7287/peerj.preprints.704v5
130 downloads
489 views

Olympia oysters are the only oyster native to the west coast of North America. The population within Puget Sound, WA has been decreasing significantly since the early 1900’s. Current restoration efforts are focused on supplementing local populations with hatchery...

["Aquaculture, Fisheries and Fish Science","Genetics"]
doi:10.7287/peerj.preprints.1595v3
80 downloads
770 views

We describe best practices for providing convenient, high-speed, secure access to large data via research data portals. We capture these best practices in a new design pattern, the Modern Research Data Portal, that disaggregates the traditional monolithic web-based...

["Computer Networks and Communications","Data Science","Distributed and Parallel Computing","Security and Privacy","World Wide Web and Web Science"]
doi:10.7287/peerj.preprints.3194v2
3 downloads
46 views

Background. Actinobacillus pleuropneumonia is a gram-negative bacterium that serves as the major etiological agent for porcine pleuropneumonia, one of critical diseases causing substantial socio-economic losses in swine rearing industry world-wide. Apx exotoxins...

["Bioinformatics","Veterinary Medicine"]
doi:10.7287/peerj.preprints.3244v1
12 downloads
42 views

In complex phenotypes (e.g., psychiatric diseases) single locus tests, commonly performed with Genome-Wide Association Studies, have proven to be limited in discovering strong gene associations. A growing body of evidence suggests that epistatic non-linear effects...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.3242v1
9 downloads
104 views

Background: Due to the interplay between many factors, systems medicine of complex diseases is most often centered either on individual genes, or on statistical associations. Complex network analysis could potentially explain systems-wide differences between patients...

["Bioinformatics"]
doi:10.7287/peerj.preprints.3241v1
8 downloads
55 views

Species distribution models (SDMs) have become important and essential tools in conservation and management. However, SDMs built with count data, commonly referred to as species abundance models (SAMs), are still less used so far. SDMs are increasingly used now...

["Biodiversity","Biogeography","Conservation Biology","Ecology","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.3240v1
83 downloads
425 views

AMNH FARB 291 is a unique sauropod dinosaur specimen, excavated in 1898 from the Bone Cabin Quarry of Wyoming (Upper Jurassic; Morrison Formation). It consists of a sequence of five contiguous dorsal vertebrae, all with biconvex centra: a morphology not previously...

["Developmental Biology","Evolutionary Studies","Paleontology"]
doi:10.7287/peerj.preprints.3144v2
3 downloads
58 views

Co-existence of microbes in a community is the de facto state of microbial lifestyle in almost all niches on Earth. Thus, microbes live with other microbial species in close proximity, and evolution has selected for specific methods of communication between microbes...

["Biochemistry","Biodiversity","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.3239v1
7 downloads
116 views

Background: Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for health and...

["Neuroscience","Epidemiology","Pharmacology","Statistics"]
doi:10.7287/peerj.preprints.3238v1
24 downloads
91 views

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system....

["Immunology"]
doi:10.7287/peerj.preprints.3237v1
9 downloads
96 views

Computational biology is rapidly advancing thanks to the many new tools developed and published each month. A systematic benchmarking practice would help biomedical researchers leverage this technological expansion to optimize their projects. Several aspects of...

["Computational Biology","Genetics","Genomics","Computational Science"]
doi:10.7287/peerj.preprints.3236v1
10 downloads
93 views

The Dipnomorpha include the extinct Porolepiformes, in addition to Powichthys and Youngolepis and the extant Dipnoi (lungfish). As sister group to the Tetrapodomorpha, the Dipnomorpha hold a valuable place in our understanding of early sarcopterygian evolution....

["Evolutionary Studies","Paleontology"]
doi:10.7287/peerj.preprints.3235v1
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