Preprints (not yet peer-reviewed)

9 downloads
67 views

Network diffusion approaches are frequently used for identifying the relevant disease genes and for prioritizing the genes for drug sensitivity predictions. Majority of these studies rely on networks representing a single type of information. However, using multiplex...

["Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.3339v1
3 downloads
18 views

Personalized medicine is in great part enabled by the progress in data acquisition technologies for modern biology, such as next-generation sequencing (NGS). Conventional NGS processing workflows are composed by independent tools implementing shared-memory parallelism...

["Bioinformatics","Computational Biology","Distributed and Parallel Computing"]
doi:10.7287/peerj.preprints.3338v1
7 downloads
90 views

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be...

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.3337v1
43 downloads
89 views

Many plant species exhibit heterophylly, displaying different leaves upon a single plant. The molecular mechanisms regulating this phenomenon, however, have remained elusive. In this study, the transcriptomes of submerged and floating leaves of an aquatic heterophyllous...

["Cell Biology","Developmental Biology","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7287/peerj.preprints.3336v1
171 downloads
433 views

Computational models in biology encode molecular and cell biological processes. These models often can be represented as biochemical reaction networks. Studying such networks, one is mostly interested in systems that share similar reactions and mechanisms. Typical...

["Bioinformatics","Computational Biology","Data Mining and Machine Learning","Data Science"]
doi:10.7287/peerj.preprints.1479v3
5 downloads
68 views

It has been estimated that up to 80% of all data stored in health care databases may have spatial components. To fully exploit such components, there is a need of improving existing tools or developing novel spatio-temporal functionalities. Geographic information...

["Data Science","Spatial and Geographic Information Systems"]
doi:10.7287/peerj.preprints.3335v1
8 downloads
37 views

The surgical skills required to successfully maintain hemostasis, the control of operative blood, requires considerable deliberate practice. Hemostasis requires the deft orchestration of bi-dexterous tool manipulation. We present our approach to computationally...

["Human-Computer Interaction","Graphics","Scientific Computing and Simulation"]
doi:10.7287/peerj.preprints.3334v1
11 downloads
171 views

The extensive coastlines of South Africa and Namibia extends from the Atlantic to the Indian Ocean and encompass several major biogeographic provinces, each characterized by unique faunal and floral assemblages. Recent biogeographic studies have led to competing...

["Biodiversity","Biogeography","Evolutionary Studies","Marine Biology","Zoology"]
doi:10.7287/peerj.preprints.3332v1
11 downloads
81 views

Background: Oxidative stress plays an important role in the pathogenesis of heart diseases. Antioxidants such as palm tocotrienol-rich fraction (TRF) can reduce oxidative stress, hence preventing and reducing the risk of heart disease. This study was aimed to determine...

["Biochemistry","Nutrition"]
doi:10.7287/peerj.preprints.3333v1
80 downloads
1,365 views

Sexual selection favors traits that increase mating and, thus, reproductive success. Some scholars have suggested that intrasexual selection driven by contest competition has shaped human male aggression. If this is the case, one testable hypothesis is that beliefs...

["Animal Behavior","Anthropology","Ecology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.3331v1
104 downloads
430 views

Microbes often live in dense, dynamic, multi-species communities whose architecture and function are intimately intertwined. Imaging these complex, three-dimensional ensembles presents considerable technical challenges, however. In this review, I describe light...

["Biophysics","Microbiology"]
doi:10.7287/peerj.preprints.3135v2
36 downloads
374 views

Several studies have demonstrated the contribution of northern immigrants to the flora of the tropical Andes – the world’s “hottest” biodiversity hotspot. However, much less is known about the biogeographic history and diversification of Andean groups with southern...

["Biogeography","Plant Science","Taxonomy"]
doi:10.7287/peerj.preprints.3330v1
11 downloads
86 views

Introduction: Tissue engineering is being redesigned through promising studies that present great potential to create biomaterials capable of forming functional tissues. The cellular expansion and integration depends very much on the quality and adequacy of the...

["Bioengineering","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.3329v1
13 downloads
140 views

As the costs of high-throughput measurement technologies continue to fall, experimental approaches in biomedicine are increasingly data intensive and the advent of big data is justifiably seen as holding the promise to transform medicine. However, as data volumes...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.3328v1
2 downloads
36 views

The methods proposed in the literature for RNA comparison focus mainly on pseudoknot free structures. The comparison of pseudoknotted structures is still a challenge. In this work, we propose a new algebraic representation of RNA secondary structures based on relations...

["Bioinformatics"]
doi:10.7287/peerj.preprints.3327v1
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