Mark van der Giezen

Summary

'19-present - Professor of Biological Chemistry, Centre for Organelle Research, University of Stavanger, Norway
'19-'19 - Associate Professor of Evolutionary Biochemistry at Biosciences, University of Exeter, UK.
'07-'18 – Senior Lecturer in Evolutionary Biochemistry at Biosciences, University of Exeter, UK.
'04–'07 Lecturer in Microbiology at the School of Biological and Chemical Sciences, Queen Mary, University of London, UK.
'02–'04 Postdoc at the School of Biological Sciences, Royal Holloway, University of London, UK.
'97–'02 EMBO Fellow at the Department of Zoology, The Natural History Museum, London, UK.
'92–'97 PhD-student in the Department of Microbiology, University of Groningen, the Netherlands

Biochemistry Evolutionary Studies Microbiology Molecular Biology Parasitology

Past or current institution affiliations

University of Stavanger

Queen Mary University of London

University of Exeter

Work details

Professor of Biological Chemistry

University of Stavanger

August 2019

Centre for Organelle Research

How microbes interact with their hosts plays an important role in human and animal health. Especially the microbes in the gut are of crucial importance. We are interested in how these microbes affect human and animal health. Our research includes important human and animal pathogens but also focusses on microbes and nutrition and their role in food security. Adaptation of microbial eukaryotes to low oxygen, as found in the gut for example, featured in several high impact publications (Nature (2003) 426, 172-176, Current Biology (2008) 18, 580-585, Current Biology (2014) 24, 1176-1186 and PLoS Biology (2017) 15(9) e2003769) and included major human pathogens such as Giardia intestinalis, Entamoeba histolytica and Blastocystis. We hope that understanding their unusual biochemistry might lead to new drug targets. Recently, we started working with the Academic Hospital here in Stavanger where we collaborate with the Gastroenterology department on studying the role of the gut microbiome in inflammataory bowel disease or IBD. Food security research focuses at biochemistry and genomics of several important livestock and fisheries pathogens such as Aphanomyces and Fasciola hepatica. Aphanomyces causes two notifyable diseases: crayfish plague (click here for new diagnostics we developed) and epizootic ulcerative syndrome in fish while Fasciola causes liver fluke in cattle and sheep. We also worked with the National Lobster Hatchery in the UK to understand the interplay between microbes and hosts, especially the role of the gut microbiome on lobster health. We described two new pathogens of Europan lobsters. We discovered the first case of an Halioticidia infection in Europe, described the first clawed lobster virus and performed a comprehensive comparative gut microbiome study on European lobsters (ISME J (2020) 14, 531–543). Fruit and vegetables improve health and cognition and it is becoming increasingly clear microbes in our alimentary tract play crucial roles in health. We work with former colleagues at Sports and Health Sciences and the Medical School at the University of Exeter (UK). We are unraveling how the microbiome of the tongue helps in healthy ageing (see for example Free Radic. Biol. Med. (2018) 124, 21-30.) Our lab uses a variety of techniques to answer our research questions. Molecular biology, cell biology, biochemistry, bioinformatics and next-generation sequencing methods are routinely used.