In this recent comment, we show that most of genes which compose the previously predicted module controling the control of the life cycle of T. cruzi are moonlighting proteins.

…read more, vote or comment

In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi’s life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the...

…read more, vote or comment