I studied theoretical physics at Radboud University, Nijmegen. I obtained my PhD degree in 2008 under the supervision of Prof. Bert Kappen in the SNN/Machine Learning group on the subject of approximate inference algorithms and Bayesian graphical models for genetic linkage analysis (Radboud University). I then moved to the UK for a postdoc with Prof. Willem Ouwehand at the University of Cambridge and Prof. Richard Durbin at the Wellcome Trust Sanger Institute. I developed algorithms for detecting genetic variation from large scale sequencing data as a member of the 1000 Genomes Project Consortium. I also analysed exome sequencing data for rare genetic disorders and identified the underlying gene for TAR syndrome and Gray Platelet Syndrome. In 2012 I moved back to the Netherlands to start my own group. We apply functional genomics methods such as ATAC-Seq and develop statistical methods to map gene regulatory networks in iPSC-derived neurons and predict the role of genetic variants for neurodevelopmental disorders.