Carlo Ennio Pucillo
Carlo Pucillo is a Full Professor in Immunology at the School of Medicine of the University of Udine.
In his scientific career Prof. Carlo Pucillo has studied the "non canonical function" of MHC class II and the molecular mechanism that regulate the B cell activation and differentiation. From 2-1991 to 6-1994 Dr Pucillo has been Visiting Scientist at NCI in Bethesda, MD-USA.
He has acquired a considerable expertise in advanced molecular biology analysis as well as a good understanding of the immunobiology of the immune response, of the non canonical function of MHC class II molecules, in particular, as documented by his publications on this subjects.
He has also investigated the signal transduction pathways elicited by T-B cell interaction via CD40-CD154. CD40 is a B cell surface receptor that belongs to the pleiotropic tumor necrosis factor receptor (TNFR) superfamily. The interaction between CD40 and its ligand promotes proliferation, cytokine production, upregulation of various surface molecules involved in antigen presentation, germinal center and memory B cell formation antibody isotype switching and affinity maturation and the B cell life span.
Most recently, his interest is in the study of regulatory role of Mast Cells in the microenvironment and subsequently in the tissutal tolerance and adaptive immune response. This body of work may provide a conceptual framework to therapeutically manipulate these responses in the settings of autoimmune disease and cancer.