Caroline Brennan
Academic Editor

Caroline Brennan


Summary

I did my PhD at King's College London in the Lab of Prof J.M. Littleton working on adaptive mechanisms underlying drug dependence. I demonstrated adaptive changes in the number of DHP sensitive VOCC following chronic exposure to central depressant drugs and showed that these changes were associated with genetic vulnerability to drug dependence.

I undertook post-doc training at the Clinical Research Centre Harrow, UK before joining the laboratory of Prof Nigel Holder at The Randall Institute, KCL and moving with him to UCL in 1998. Whilst at KCL and UCL I used zebrafish as a genetic model system for analysis of mechanisms underlying development.

Since 2000, I have been a Lecturer in Molecular Genetics in the School of Biological Sciences QMUL. Our work combines the two areas of my expertise: Molecular mechanisms underlying drug dependence and zebrafish as a developmental genetic model system. We have developed behavioural assays of drug seeking, compulsive drug seeking and relapse in zebrafish and are establishing lines of fish in which to explore the genetics contributing to these behaviours.

Animal Behavior Cognitive Disorders Developmental Biology Neuroscience

Institution affiliations

Work details

Reader in Molecular Genetics

Queen Mary University of London
School of Biological and Chemical Sciences
We are interested in the molecular mechanisms controlling behaviour. We are particularly interested in endophenotypes associated with psychological disease including drug addiction and dementia. We use zebrafish as our model system combining behavioural analysis, imaging and cell biology techniques in wild type, mutant and transgenic lines to investigate the neural correlates of reward and learning behaviours.

PeerJ Contributions