PeerJ Analytical Chemistry has recently published our first Method Development Article, which investigates a method for direct determination of the optical density at 260 nm (OD260) of Oligodeoxynucleotides (ODNs) using the area of the peaks in high-performance liquid chromatography profiles.
Komal Chillar et al., the authors of “Determination of optical density (OD) of oligodeoxynucleotide from HPLC peak area“, suggest that this method will save significant time for researchers in the area of nucleic acid research, and minimize the loss of oligonucleotide samples.
Method Development Articles
We encourage the submission of further fully-validated methodological papers across all five of our chemistry/materials science journals. Each Method Development Article should include a rationale for why it is needed, describe who it is intended for, and include a comprehensive description of the procedures used. They should also demonstrate the reliability of the method and a robust validation. Current limitations of methodologies in the literature should be clearly identified. Please see https://peerj.com/about/aims-and-scope/chemistry for full guidance.