PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: The first fossil immature of Elmidae: an unusual riffle beetle larva preserved in Baltic amber
items: Antagonistic co-contraction can minimize muscular effort in systems with uncertainty
items: https://peerj.com/articles/13121
items: The soft tissue and skeletal anatomy of two Late Jurassic ichthyosaur specimens from the Solnhofen archipelago
items: Putting small and big pieces together: a genome assembly approach reveals the largest Lamiid plastome in a woody vine
items: A new basal ichthyosauromorph from the Lower Triassic (Olenekian) of Zhebao, Guangxi Autonomous Region, South China
items: Burden of COVID-19: a preliminary analysis in the population of Saudi Arabia
items: https://peerj.com/articles/13228
items: Historical significance and taxonomic status of Ischyrodon meriani (Pliosauridae) from the Middle Jurassic of Switzerland
items: Soil metabolomics and bacterial functional traits revealed the responses of rhizosphere soil bacterial community to long-term continuous cropping of Tibetan barley

The first fossil immature of Elmidae: an unusual riffle beetle larva preserved in Baltic amber
type: item
type: AcademicArticle
description: Elmidae, riffle beetles, have both adult and immature stages that show specializations for water environments. Fossils of adults of Elmidae are already known from amber, however a record of immatures was so far lacking. We report here the first fossil larva of Elmidae, preserved in Baltic amber. To be able to access details of the body hidden by inclusions and “Verlumung” we conducted, in addition to optical documentation methods, micro-CT and synchrotron documentation methods. The larva is characterised by prominent dorso-lateral and lateral processes and a plate-like ventral operculum at the end of the abdomen. The new fossil has similarities in the general body shape and the prominent characters with some modern larvae of Elmidae. The posterior protrusions on the trunk end possibly represent gills, which would imply that fossil larvae of Elmidae also led a water-related life style similar to modern representatives.
format: application/pdf
format: text/html
creator: Ana Zippel
creator: Viktor A. Baranov
creator: Jörg U. Hammel
creator: Marie K. Hörnig
creator: Carolin Haug
creator: Joachim T. Haug
subject: Entomology
subject: Evolutionary Studies
subject: Paleontology
subject: Zoology
description: doi:10.7717/peerj.13025
publisher: PeerJ Inc.
rights: © 2022 Zippel et al.
abstract: Elmidae, riffle beetles, have both adult and immature stages that show specializations for water environments. Fossils of adults of Elmidae are already known from amber, however a record of immatures was so far lacking. We report here the first fossil larva of Elmidae, preserved in Baltic amber. To be able to access details of the body hidden by inclusions and “Verlumung” we conducted, in addition to optical documentation methods, micro-CT and synchrotron documentation methods. The larva is characterised by prominent dorso-lateral and lateral processes and a plate-like ventral operculum at the end of the abdomen. The new fossil has similarities in the general body shape and the prominent characters with some modern larvae of Elmidae. The posterior protrusions on the trunk end possibly represent gills, which would imply that fossil larvae of Elmidae also led a water-related life style similar to modern representatives.
bibliographic citation: Zippel et al. (2022) The first fossil immature of Elmidae: an unusual riffle beetle larva preserved in Baltic amber. PeerJ 10:e13025 https://doi.org/10.7717/peerj.13025
date submitted: 2021-12-13
date accepted: 2022-02-07
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Zippel
  given name: Ana
author list: Agent
  family name: Baranov
  given name: Viktor A.
author list: Agent
  family name: Hammel
  given name: Jörg U.
author list: Agent
  family name: Hörnig
  given name: Marie K.
author list: Agent
  family name: Haug
  given name: Carolin
author list: Agent
  family name: Haug
  given name: Joachim T.
doi: 10.7717/peerj.13025
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: ©2022 Zippel et al.
attribution name: Zippel et al.

Antagonistic co-contraction can minimize muscular effort in systems with uncertainty
type: item
type: AcademicArticle
description: Muscular co-contraction of antagonistic muscle pairs is often observed in human movement, but it is considered inefficient and it can currently not be predicted in simulations where muscular effort or metabolic energy are minimized. Here, we investigated the relationship between minimizing effort and muscular co-contraction in systems with random uncertainty to see if muscular co-contraction can minimize effort in such system. We also investigated the effect of time delay in the muscle, by varying the time delay in the neural control as well as the activation time constant. We solved optimal control problems for a one-degree-of-freedom pendulum actuated by two identical antagonistic muscles, using forward shooting, to find controller parameters that minimized muscular effort while the pendulum remained upright in the presence of noise added to the moment at the base of the pendulum. We compared a controller with and without feedforward control. Task precision was defined by bounding the root mean square deviation from the upright position, while different perturbation levels defined task difficulty. We found that effort was minimized when the feedforward control was nonzero, even when feedforward control was not necessary to perform the task, which indicates that co-contraction can minimize effort in systems with uncertainty. We also found that the optimal level of co-contraction increased with time delay, both when the activation time constant was increased and when neural time delay was added. Furthermore, we found that for controllers with a neural time delay, a different trajectory was optimal for a controller with feedforward control than for one without, which indicates that simulation trajectories are dependent on the controller architecture. Future movement predictions should therefore account for uncertainty in dynamics and control, and carefully choose the controller architecture. The ability of models to predict co-contraction from effort or energy minimi…
format: application/pdf
format: text/html
creator: Anne D. Koelewijn
creator: Antonie J. Van Den Bogert
subject: Anatomy and Physiology
subject: Kinesiology
subject: Biomechanics
description: doi:10.7717/peerj.13085
publisher: PeerJ Inc.
rights: © 2022 Koelewijn and Van Den Bogert
abstract: Muscular co-contraction of antagonistic muscle pairs is often observed in human movement, but it is considered inefficient and it can currently not be predicted in simulations where muscular effort or metabolic energy are minimized. Here, we investigated the relationship between minimizing effort and muscular co-contraction in systems with random uncertainty to see if muscular co-contraction can minimize effort in such system. We also investigated the effect of time delay in the muscle, by varying the time delay in the neural control as well as the activation time constant. We solved optimal control problems for a one-degree-of-freedom pendulum actuated by two identical antagonistic muscles, using forward shooting, to find controller parameters that minimized muscular effort while the pendulum remained upright in the presence of noise added to the moment at the base of the pendulum. We compared a controller with and without feedforward control. Task precision was defined by bounding the root mean square deviation from the upright position, while different perturbation levels defined task difficulty. We found that effort was minimized when the feedforward control was nonzero, even when feedforward control was not necessary to perform the task, which indicates that co-contraction can minimize effort in systems with uncertainty. We also found that the optimal level of co-contraction increased with time delay, both when the activation time constant was increased and when neural time delay was added. Furthermore, we found that for controllers with a neural time delay, a different trajectory was optimal for a controller with feedforward control than for one without, which indicates that simulation trajectories are dependent on the controller architecture. Future movement predictions should therefore account for uncertainty in dynamics and control, and carefully choose the controller architecture. The ability of models to predict co-contraction from effort or energy minimi…
bibliographic citation: Koelewijn et al. (2022) Antagonistic co-contraction can minimize muscular effort in systems with uncertainty. PeerJ 10:e13085 https://doi.org/10.7717/peerj.13085
date submitted: 2021-10-13
date accepted: 2022-02-17
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Koelewijn
  given name: Anne D.
author list: Agent
  family name: Van Den Bogert
  given name: Antonie J.
doi: 10.7717/peerj.13085
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: © 2022 Koelewijn and Van Den Bogert
attribution name: Koelewijn and Van Den Bogert

https://peerj.com/articles/13121
type: item
type: AcademicArticle
title: Alleviation of drought stress by root-applied thiourea is related to elevated photosynthetic pigments, osmoprotectants, antioxidant enzymes, and tubers yield and suppressed oxidative stress in potatoes cultivars
description: The growth and productivity of plants are enhanced by the use of thiourea (TU) under stressful conditions. When TU is applied as a rooting medium, it improves plant growth characteristics and other physiological parameters in stressed environment. A pot experiment was conducted in the botanical garden of the Government College University, Faisalabad 38000, Pakistan to examine the TU-mediated fluctuations in some crucial physio-biochemical parameters and the oxidative defense of potatoes under a restricted water supply. For this purpose, two potato cultivars (potato-SH-5 and potato-FD-73) were sown in pots containing 10 kg of soil. Water was regularly applied to the pots until germination. After 2 weeks of germination, drought stress with 65% field capacity was imposed, while the control was subjected to 100% field capacity. TU, as a rooting medium, was applied at the vegetative stage (0 (no application), 0.5, 0.75 mM). A substantial reduction in the total number of leaves, leaf area, tuber biomass (fresh and dry weight), photosynthetic pigments, membrane permeability, and leaf relative water content (RWC) was recorded in plants under drought stress conditions as compared to control plants. The damaging eﬀects of water stress were more critical for cv. potato-FD-73 as compared to cv. potato-SH-5. In contrast, drought stress enhanced the malondialdehyde (MDA) and hydrogen peroxide (H2O2) content while also increased antioxidant enzyme activities (superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT)) and triggered the accumulation of soluble proteins, soluble sugars, proline, and phenolic and anthocyanin contents. However, TU applied as rooting medium at 0.5 and 0.75 mM was eﬀective in reducing the detrimental eﬀects of water stress in both cultivars. Furthermore, increasing levels of TU enhanced chlorophyll pigments, dissolved proteins, complete dissolved sugars, and enzymatic capabilities of POD, SOD, and CAT, while reducing the MDA and H2O2 in both culti…
format: application/pdf
format: text/html
creator: Muhammad Hamzah Saleem
creator: Xiukang Wang
creator: Abida Parveen
creator: Shagufta Perveen
creator: Saqib Mehmood
creator: Sajid Fiaz
creator: Sajjad Ali
creator: Sajjad Hussain
creator: Muhammad Adnan
creator: Naeem Iqbal
creator: Aishah Alatawi
creator: Shafaqat Ali
subject: Agricultural Science
subject: Biochemistry
subject: Plant Science
description: doi:10.7717/peerj.13121
publisher: PeerJ Inc.
rights: © 2022 Saleem et al.
abstract: The growth and productivity of plants are enhanced by the use of thiourea (TU) under stressful conditions. When TU is applied as a rooting medium, it improves plant growth characteristics and other physiological parameters in stressed environment. A pot experiment was conducted in the botanical garden of the Government College University, Faisalabad 38000, Pakistan to examine the TU-mediated fluctuations in some crucial physio-biochemical parameters and the oxidative defense of potatoes under a restricted water supply. For this purpose, two potato cultivars (potato-SH-5 and potato-FD-73) were sown in pots containing 10 kg of soil. Water was regularly applied to the pots until germination. After 2 weeks of germination, drought stress with 65% field capacity was imposed, while the control was subjected to 100% field capacity. TU, as a rooting medium, was applied at the vegetative stage (0 (no application), 0.5, 0.75 mM). A substantial reduction in the total number of leaves, leaf area, tuber biomass (fresh and dry weight), photosynthetic pigments, membrane permeability, and leaf relative water content (RWC) was recorded in plants under drought stress conditions as compared to control plants. The damaging eﬀects of water stress were more critical for cv. potato-FD-73 as compared to cv. potato-SH-5. In contrast, drought stress enhanced the malondialdehyde (MDA) and hydrogen peroxide (H2O2) content while also increased antioxidant enzyme activities (superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT)) and triggered the accumulation of soluble proteins, soluble sugars, proline, and phenolic and anthocyanin contents. However, TU applied as rooting medium at 0.5 and 0.75 mM was eﬀective in reducing the detrimental eﬀects of water stress in both cultivars. Furthermore, increasing levels of TU enhanced chlorophyll pigments, dissolved proteins, complete dissolved sugars, and enzymatic capabilities of POD, SOD, and CAT, while reducing the MDA and H2O2 in both culti…
bibliographic citation: Saleem et al. (2022) Alleviation of drought stress by root-applied thiourea is related to elevated photosynthetic pigments, osmoprotectants, antioxidant enzymes, and tubers yield and suppressed oxidative stress in potatoes cultivars. PeerJ 10:e13121 https://doi.org/10.7717/peerj.13121
date submitted: 2021-07-05
date accepted: 2022-02-24
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Saleem
  given name: Muhammad Hamzah
author list: Agent
  family name: Wang
  given name: Xiukang
author list: Agent
  family name: Parveen
  given name: Abida
author list: Agent
  family name: Perveen
  given name: Shagufta
author list: Agent
  family name: Mehmood
  given name: Saqib
author list: Agent
  family name: Fiaz
  given name: Sajid
author list: Agent
  family name: Ali
  given name: Sajjad
author list: Agent
  family name: Hussain
  given name: Sajjad
author list: Agent
  family name: Adnan
  given name: Muhammad
author list: Agent
  family name: Iqbal
  given name: Naeem
author list: Agent
  family name: Alatawi
  given name: Aishah
author list: Agent
  family name: Ali
  given name: Shafaqat
doi: 10.7717/peerj.13121
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: © 2022 Saleem et al.
attribution name: Saleem et al.

The soft tissue and skeletal anatomy of two Late Jurassic ichthyosaur specimens from the Solnhofen archipelago
type: item
type: AcademicArticle
description: Ichthyosaurs from the Solnhofen Lagerstätte are among the only examples of soft tissue preservation in the major Middle Jurassic–middle Cretaceous family Ophthalmosauridae. However, few such specimens are currently described, and the taphonomical pathways for the preservation of soft tissue are not well understood. In order to answer this, two new ichthyosaur specimens, one nearly complete and one isolated tail, are described here. The nearly complete specimen is assigned to Aegirosaurus sp. It is accompanied by large amounts of incrustation pseudomorphs (epimorphs) of soft tissue preserved as apatite. It also preserves a nearly complete gastral basket, for the first time in ophthalmosaurids. Soft tissue samples were analyzed using X-ray diffraction (XRD) and scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS) analysis. The analyses confirm the presence of apatite, with phosphate most likely derived from the body itself.
format: application/pdf
format: text/html
creator: Lene L. Delsett
creator: Henrik Friis
creator: Martina Kölbl-Ebert
creator: Jørn H. Hurum
subject: Evolutionary Studies
subject: Paleontology
subject: Taxonomy
subject: Zoology
description: doi:10.7717/peerj.13173
publisher: PeerJ Inc.
rights: © 2022 Delsett et al.
abstract: Ichthyosaurs from the Solnhofen Lagerstätte are among the only examples of soft tissue preservation in the major Middle Jurassic–middle Cretaceous family Ophthalmosauridae. However, few such specimens are currently described, and the taphonomical pathways for the preservation of soft tissue are not well understood. In order to answer this, two new ichthyosaur specimens, one nearly complete and one isolated tail, are described here. The nearly complete specimen is assigned to Aegirosaurus sp. It is accompanied by large amounts of incrustation pseudomorphs (epimorphs) of soft tissue preserved as apatite. It also preserves a nearly complete gastral basket, for the first time in ophthalmosaurids. Soft tissue samples were analyzed using X-ray diffraction (XRD) and scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS) analysis. The analyses confirm the presence of apatite, with phosphate most likely derived from the body itself.
bibliographic citation: Delsett et al. (2022) The soft tissue and skeletal anatomy of two Late Jurassic ichthyosaur specimens from the Solnhofen archipelago. PeerJ 10:e13173 https://doi.org/10.7717/peerj.13173
date submitted: 2021-11-26
date accepted: 2022-03-06
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Delsett
  given name: Lene L.
author list: Agent
  family name: Friis
  given name: Henrik
author list: Agent
  family name: Kölbl-Ebert
  given name: Martina
author list: Agent
  family name: Hurum
  given name: Jørn H.
doi: 10.7717/peerj.13173
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: © 2022 Delsett et al.
attribution name: Delsett et al.

Putting small and big pieces together: a genome assembly approach reveals the largest Lamiid plastome in a woody vine
type: item
type: AcademicArticle
description: The plastid genome of flowering plants generally shows conserved structural organization, gene arrangement, and gene content. While structural reorganizations are uncommon, examples have been documented in the literature during the past years. Here we assembled the entire plastome of Bignonia magnifica and compared its structure and gene content with nine other Lamiid plastomes. The plastome of B. magnifica is composed of 183,052 bp and follows the canonical quadripartite structure, synteny, and gene composition of other angiosperms. Exceptionally large inverted repeat (IR) regions are responsible for the uncommon length of the genome. At least four events of IR expansion were observed among the seven Bignoniaceae species compared, suggesting multiple expansions of the IRs over the SC regions in the family. A comparison with 6,231 other complete plastomes of flowering plants available on GenBank revealed that the plastome of B. magnifica is the longest Lamiid plastome described to date. The newly generated plastid genome was used as a source of selected genes. These genes were combined with orthologous regions sampled from other species of Bignoniaceae and all gene alignments concatenated to infer a phylogeny of the family. The tree recovered is consistent with known relationships within the Bignoniaceae.
format: application/pdf
format: text/html
creator: Luiz Henrique M. Fonseca
creator: Alison G. Nazareno
creator: Verônica A. Thode
creator: Alexandre R. Zuntini
creator: Lúcia G. Lohmann
subject: Genomics
subject: Molecular Biology
subject: Plant Science
description: doi:10.7717/peerj.13207
publisher: PeerJ Inc.
rights: © 2022 Fonseca et al.
abstract: The plastid genome of flowering plants generally shows conserved structural organization, gene arrangement, and gene content. While structural reorganizations are uncommon, examples have been documented in the literature during the past years. Here we assembled the entire plastome of Bignonia magnifica and compared its structure and gene content with nine other Lamiid plastomes. The plastome of B. magnifica is composed of 183,052 bp and follows the canonical quadripartite structure, synteny, and gene composition of other angiosperms. Exceptionally large inverted repeat (IR) regions are responsible for the uncommon length of the genome. At least four events of IR expansion were observed among the seven Bignoniaceae species compared, suggesting multiple expansions of the IRs over the SC regions in the family. A comparison with 6,231 other complete plastomes of flowering plants available on GenBank revealed that the plastome of B. magnifica is the longest Lamiid plastome described to date. The newly generated plastid genome was used as a source of selected genes. These genes were combined with orthologous regions sampled from other species of Bignoniaceae and all gene alignments concatenated to infer a phylogeny of the family. The tree recovered is consistent with known relationships within the Bignoniaceae.
bibliographic citation: Fonseca et al. (2022) Putting small and big pieces together: a genome assembly approach reveals the largest Lamiid plastome in a woody vine. PeerJ 10:e13207 https://doi.org/10.7717/peerj.13207
date submitted: 2021-11-26
date accepted: 2022-03-10
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Fonseca
  given name: Luiz Henrique M.
author list: Agent
  family name: Nazareno
  given name: Alison G.
author list: Agent
  family name: Thode
  given name: Verônica A.
author list: Agent
  family name: Zuntini
  given name: Alexandre R.
author list: Agent
  family name: Lohmann
  given name: Lúcia G.
doi: 10.7717/peerj.13207
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: ©2022 Fonseca et al.
attribution name: Fonseca et al.

A new basal ichthyosauromorph from the Lower Triassic (Olenekian) of Zhebao, Guangxi Autonomous Region, South China
type: item
type: AcademicArticle
description: Here we describe a newly discovered basal ichthyosauromorph from the Lower Triassic of South China, Baisesaurus robustus gen. et sp. nov. The only known specimen of this new species was collected from the Lower Triassic (Olenekian) Luolou Formation in the Zhebao region of Baise City, on the northwest margin of the Nanpanjiang Basin, and comprises a partial skeleton including the ribs, the gastralia, a limb element, 12 centra, and seven neural arches. Comparisons to a wide variety of Early Triassic marine reptiles show Baisesaurus robustus to be a basal ichthyosauromorph based on the following features: neural arches lack transverse processes; dorsal ribs are slender, and not pachyostotic even proximally; and median gastral elements have long, sharp anterior processes. The limb element is long and robust, and is most likely to be a radius. Baisesaurus robustus is large (estimated length more than 3 m) relative to early ichthyosauromorphs previously discovered in China, and shares noteworthy morphological similarities with Utatsusaurus hataii, particularly with regard to body size and the morphology of the probable radius. Baisesaurus robustus also represents the first record of an Early Triassic ichthyosauromorph from Guangxi Autonomous Region, extending the known geographic distribution of ichthyosauromorphs in South China.
format: application/pdf
format: text/html
creator: Jicheng Ren
creator: Haishui Jiang
creator: Kunpeng Xiang
creator: Corwin Sullivan
creator: Yongzhong He
creator: Long Cheng
creator: Fenglu Han
subject: Evolutionary Studies
subject: Paleontology
subject: Zoology
description: doi:10.7717/peerj.13209
publisher: PeerJ Inc.
rights: © 2022 Ren et al.
abstract: Here we describe a newly discovered basal ichthyosauromorph from the Lower Triassic of South China, Baisesaurus robustus gen. et sp. nov. The only known specimen of this new species was collected from the Lower Triassic (Olenekian) Luolou Formation in the Zhebao region of Baise City, on the northwest margin of the Nanpanjiang Basin, and comprises a partial skeleton including the ribs, the gastralia, a limb element, 12 centra, and seven neural arches. Comparisons to a wide variety of Early Triassic marine reptiles show Baisesaurus robustus to be a basal ichthyosauromorph based on the following features: neural arches lack transverse processes; dorsal ribs are slender, and not pachyostotic even proximally; and median gastral elements have long, sharp anterior processes. The limb element is long and robust, and is most likely to be a radius. Baisesaurus robustus is large (estimated length more than 3 m) relative to early ichthyosauromorphs previously discovered in China, and shares noteworthy morphological similarities with Utatsusaurus hataii, particularly with regard to body size and the morphology of the probable radius. Baisesaurus robustus also represents the first record of an Early Triassic ichthyosauromorph from Guangxi Autonomous Region, extending the known geographic distribution of ichthyosauromorphs in South China.
bibliographic citation: Ren et al. (2022) A new basal ichthyosauromorph from the Lower Triassic (Olenekian) of Zhebao, Guangxi Autonomous Region, South China. PeerJ 10:e13209 https://doi.org/10.7717/peerj.13209
date submitted: 2021-05-20
date accepted: 2022-03-10
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Ren
  given name: Jicheng
author list: Agent
  family name: Jiang
  given name: Haishui
author list: Agent
  family name: Xiang
  given name: Kunpeng
author list: Agent
  family name: Sullivan
  given name: Corwin
author list: Agent
  family name: He
  given name: Yongzhong
author list: Agent
  family name: Cheng
  given name: Long
author list: Agent
  family name: Han
  given name: Fenglu
doi: 10.7717/peerj.13209
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: © 2022 Ren et al.
attribution name: Ren et al.

Burden of COVID-19: a preliminary analysis in the population of Saudi Arabia
type: item
type: AcademicArticle
description: Background Coronavirus infection (COVID-19) has resulted in an unprecedented number of human deaths and economic losses. Analyzing the role of disease in different groups of people is useful for determining the burden of disease. As a result, the purpose of this study was to investigate the influence of COVID-19 on the Saudi Arabian population’s quality of life, with a particular emphasis on the likely fall in their life expectancy. Methods A cross-sectional and retrospective analysis of 2,988 patients’ databases was performed to assess COVID-19-induced mortality and complications in the community. The data was gathered from official websites that track the disease’s impact daily between July and October 2021. On the acquired data, disability-adjusted life years (DALYs) and relative risk analysis were performed. The data was statistically analyzed using SPSS IBM 25. The Pearson’s correlation test was used to examine the relationship between age and disease impact. The significance of the findings was determined by using a P value of less than 0.05. Results The data from the study indicated that the positive test rate, infection rate, and mortality rate in the population were 1.84% [+0.11/-0.39 of 95% confidence interval (CI)], 1.54% (+0.38/-0.52 of CI), and 1.59% (+0.4/-0.7 of CI), respectively. Highest percentage of mortality was observed in Riyadh (17%), followed by Jeddah (8.7%) and Makkah (7.5%). The DALYs/100,000 inhabitants increased progressively as the age of the population increased, and the highest value was found for those over 70 years old (25.73 ± 2.09). Similarly, the risk outcome (55%) increased significantly (p = 0.037) from 40 years onwards, and the maximum was observed at above 70 years (184%, p = 0.006). The correlation analysis indicated a significant association (p = 0.032) between age and COVID-19 induced mortality from the 40-year-old population onwards. Conclusion The current study found that the COVID-19 load in Saudi Arabia was comparable t…
format: application/pdf
format: text/html
creator: Syed Mohammed Basheeruddin Asdaq
creator: Syed Imam Rabbani
creator: Mohammed Kanan Alshammari
creator: Reem Saud Alshammari
creator: Mehnaz Kamal
creator: Mohd Imran
creator: Noufah Aqeel AlShammari
creator: May Faiz Al Twallah
creator: Abdulmjeed Hussain Alshahrani
subject: Epidemiology
subject: Infectious Diseases
subject: COVID-19
description: doi:10.7717/peerj.13219
publisher: PeerJ Inc.
rights: © 2022 Asdaq et al.
abstract: Background Coronavirus infection (COVID-19) has resulted in an unprecedented number of human deaths and economic losses. Analyzing the role of disease in different groups of people is useful for determining the burden of disease. As a result, the purpose of this study was to investigate the influence of COVID-19 on the Saudi Arabian population’s quality of life, with a particular emphasis on the likely fall in their life expectancy. Methods A cross-sectional and retrospective analysis of 2,988 patients’ databases was performed to assess COVID-19-induced mortality and complications in the community. The data was gathered from official websites that track the disease’s impact daily between July and October 2021. On the acquired data, disability-adjusted life years (DALYs) and relative risk analysis were performed. The data was statistically analyzed using SPSS IBM 25. The Pearson’s correlation test was used to examine the relationship between age and disease impact. The significance of the findings was determined by using a P value of less than 0.05. Results The data from the study indicated that the positive test rate, infection rate, and mortality rate in the population were 1.84% [+0.11/-0.39 of 95% confidence interval (CI)], 1.54% (+0.38/-0.52 of CI), and 1.59% (+0.4/-0.7 of CI), respectively. Highest percentage of mortality was observed in Riyadh (17%), followed by Jeddah (8.7%) and Makkah (7.5%). The DALYs/100,000 inhabitants increased progressively as the age of the population increased, and the highest value was found for those over 70 years old (25.73 ± 2.09). Similarly, the risk outcome (55%) increased significantly (p = 0.037) from 40 years onwards, and the maximum was observed at above 70 years (184%, p = 0.006). The correlation analysis indicated a significant association (p = 0.032) between age and COVID-19 induced mortality from the 40-year-old population onwards. Conclusion The current study found that the COVID-19 load in Saudi Arabia was comparable t…
bibliographic citation: Asdaq et al. (2022) Burden of COVID-19: a preliminary analysis in the population of Saudi Arabia. PeerJ 10:e13219 https://doi.org/10.7717/peerj.13219
date submitted: 2021-11-18
date accepted: 2022-03-14
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Asdaq
  given name: Syed Mohammed Basheeruddin
author list: Agent
  family name: Rabbani
  given name: Syed Imam
author list: Agent
  family name: Alshammari
  given name: Mohammed Kanan
author list: Agent
  family name: Alshammari
  given name: Reem Saud
author list: Agent
  family name: Kamal
  given name: Mehnaz
author list: Agent
  family name: Imran
  given name: Mohd
author list: Agent
  family name: AlShammari
  given name: Noufah Aqeel
author list: Agent
  family name: Al Twallah
  given name: May Faiz
author list: Agent
  family name: Alshahrani
  given name: Abdulmjeed Hussain
doi: 10.7717/peerj.13219
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: ©2022 Asdaq et al.
attribution name: Asdaq et al.

https://peerj.com/articles/13228
type: item
type: AcademicArticle
title: Validating an inertial measurement unit for cricket fast bowling: a first step in assessing the feasibility of diagnosing back injury risk in cricket fast bowlers during a tele-sport-and-exercise medicine consultation
description: This study aimed to validate an array-based inertial measurement unit to measure cricket fast bowling kinematics as a first step in assessing feasibility for tele-sport-and-exercise medicine. We concurrently captured shoulder girdle relative to the pelvis, trunk lateral flexion, and knee flexion angles at front foot contact of eight cricket medium-fast bowlers using inertial measurement unit and optical motion capture. We used one sample t-tests and 95% limits of agreement (LOA) to determine the mean difference between the two systems and Smallest Worth-while Change statistic to determine whether any differences were meaningful. A statistically significant (p < 0.001) but small mean difference of −4.7° ± 8.6° (95% Confidence Interval (CI) [−3.1° to −6.4°], LOA [−22.2 to 12.7], SWC 3.9°) in shoulder girdle relative to the pelvis angle was found between the systems. There were no statistically significant differences between the two systems in trunk lateral flexion and knee flexion with the mean differences being 0.1° ± 10.8° (95% CI [−1.9° to 2.2°], LOA [−22.5 to 22.7], SWC 1.2°) and 1.6° ± 10.1° (95% CI [−0.2° to 3.3°], LOA [−19.2 to 22.3], SWC 1.9°) respectively. The inertial measurement unit-based system tested allows for accurate measurement of specific cricket fast bowling kinematics and could be used in determining injury risk in the context of tele-sport-and-exercise-medicine.
format: application/pdf
format: text/html
creator: Keegan Harnett
creator: Brenda Plint
creator: Ka Yan Chan
creator: Benjamin Clark
creator: Kevin Netto
creator: Paul Davey
creator: Sean Müller
creator: Simon Rosalie
subject: Orthopedics
subject: Biomechanics
subject: Sports Medicine
description: doi:10.7717/peerj.13228
publisher: PeerJ Inc.
rights: © 2022 Harnett et al.
abstract: This study aimed to validate an array-based inertial measurement unit to measure cricket fast bowling kinematics as a first step in assessing feasibility for tele-sport-and-exercise medicine. We concurrently captured shoulder girdle relative to the pelvis, trunk lateral flexion, and knee flexion angles at front foot contact of eight cricket medium-fast bowlers using inertial measurement unit and optical motion capture. We used one sample t-tests and 95% limits of agreement (LOA) to determine the mean difference between the two systems and Smallest Worth-while Change statistic to determine whether any differences were meaningful. A statistically significant (p < 0.001) but small mean difference of −4.7° ± 8.6° (95% Confidence Interval (CI) [−3.1° to −6.4°], LOA [−22.2 to 12.7], SWC 3.9°) in shoulder girdle relative to the pelvis angle was found between the systems. There were no statistically significant differences between the two systems in trunk lateral flexion and knee flexion with the mean differences being 0.1° ± 10.8° (95% CI [−1.9° to 2.2°], LOA [−22.5 to 22.7], SWC 1.2°) and 1.6° ± 10.1° (95% CI [−0.2° to 3.3°], LOA [−19.2 to 22.3], SWC 1.9°) respectively. The inertial measurement unit-based system tested allows for accurate measurement of specific cricket fast bowling kinematics and could be used in determining injury risk in the context of tele-sport-and-exercise-medicine.
bibliographic citation: Harnett et al. (2022) Validating an inertial measurement unit for cricket fast bowling: a first step in assessing the feasibility of diagnosing back injury risk in cricket fast bowlers during a tele-sport-and-exercise medicine consultation. PeerJ 10:e13228 https://doi.org/10.7717/peerj.13228
date submitted: 2021-12-01
date accepted: 2022-03-15
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Harnett
  given name: Keegan
author list: Agent
  family name: Plint
  given name: Brenda
author list: Agent
  family name: Chan
  given name: Ka Yan
author list: Agent
  family name: Clark
  given name: Benjamin
author list: Agent
  family name: Netto
  given name: Kevin
author list: Agent
  family name: Davey
  given name: Paul
author list: Agent
  family name: Müller
  given name: Sean
author list: Agent
  family name: Rosalie
  given name: Simon
doi: 10.7717/peerj.13228
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: © 2022 Harnett et al.
attribution name: Harnett et al.

Historical significance and taxonomic status of Ischyrodon meriani (Pliosauridae) from the Middle Jurassic of Switzerland
type: item
type: AcademicArticle
description: Ischyrodon meriani is an obscure pliosaurid taxon established upon an exceptionally large tooth crown of a probable Callovian (Middle Jurassic) age that originates from Wölflinswil, Canton of Aargau, Switzerland. Despite being known for almost two centuries, the specimen remains poorly researched. Historically, I. meriani has been associated, or even considered conspecific, with Pliosaurus macromerus and Liopleurodon ferox. However, neither of the two hypotheses have been tested through detailed comparisons or using modern quantitative methods. Here, we redescribe the type of Ischyrodon meriani, illustrate it, and compare to teeth of thalassophonean pliosaurids, with special focus on Jurassic representatives of the clade. Multivariate analyses show close similarities to L. ferox but comparable structures to those of I. meriani, including a distinctive pattern of the apicobasal ridges, are also observable in some mid-Cretaceous brachauchenines from the ‘Polyptychodon’ assemblage of East and South East England. While it is likely that I. meriani represents a Liopleurodon-like taxon, or is indeed conspecific with L. ferox, which would make I. meriani the proper name for the species, any such taxonomic considerations are hindered by the fragmentary nature of the type specimens of both these taxa as well as limited knowledge of the dental variability within and between individual jaws of L. ferox. Currently, I. meriani is best treated as a nomen dubium. Finally, we discuss the potential implications of I. meriani being conspecific with L. ferox, and additionally provide a commentary on the taxonomic status of Liopleurodon.
format: application/pdf
format: text/html
creator: Daniel Madzia
creator: Sven Sachs
creator: Christian Klug
subject: Evolutionary Studies
subject: Paleontology
subject: Taxonomy
subject: Zoology
description: doi:10.7717/peerj.13244
publisher: PeerJ Inc.
rights: © 2022 Madzia et al.
abstract: Ischyrodon meriani is an obscure pliosaurid taxon established upon an exceptionally large tooth crown of a probable Callovian (Middle Jurassic) age that originates from Wölflinswil, Canton of Aargau, Switzerland. Despite being known for almost two centuries, the specimen remains poorly researched. Historically, I. meriani has been associated, or even considered conspecific, with Pliosaurus macromerus and Liopleurodon ferox. However, neither of the two hypotheses have been tested through detailed comparisons or using modern quantitative methods. Here, we redescribe the type of Ischyrodon meriani, illustrate it, and compare to teeth of thalassophonean pliosaurids, with special focus on Jurassic representatives of the clade. Multivariate analyses show close similarities to L. ferox but comparable structures to those of I. meriani, including a distinctive pattern of the apicobasal ridges, are also observable in some mid-Cretaceous brachauchenines from the ‘Polyptychodon’ assemblage of East and South East England. While it is likely that I. meriani represents a Liopleurodon-like taxon, or is indeed conspecific with L. ferox, which would make I. meriani the proper name for the species, any such taxonomic considerations are hindered by the fragmentary nature of the type specimens of both these taxa as well as limited knowledge of the dental variability within and between individual jaws of L. ferox. Currently, I. meriani is best treated as a nomen dubium. Finally, we discuss the potential implications of I. meriani being conspecific with L. ferox, and additionally provide a commentary on the taxonomic status of Liopleurodon.
bibliographic citation: Madzia et al. (2022) Historical significance and taxonomic status of Ischyrodon meriani (Pliosauridae) from the Middle Jurassic of Switzerland. PeerJ 10:e13244 https://doi.org/10.7717/peerj.13244
date submitted: 2022-01-13
date accepted: 2022-03-18
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Madzia
  given name: Daniel
author list: Agent
  family name: Sachs
  given name: Sven
author list: Agent
  family name: Klug
  given name: Christian
doi: 10.7717/peerj.13244
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: ©2022 Madzia et al.
attribution name: Madzia et al.

Soil metabolomics and bacterial functional traits revealed the responses of rhizosphere soil bacterial community to long-term continuous cropping of Tibetan barley
type: item
type: AcademicArticle
description: Continuous cropping often leads to an unbalanced soil microbial community, which in turn negatively affects soil functions. However, systematic research of how these effects impact the bacterial composition, microbial functional traits, and soil metabolites is lacking. In the present study, the rhizosphere soil samples of Tibetan barley continuously monocropped for 2 (CCY02), 5 (CCY05), and 10 (CCY10) years were collected. By utilizing 16S high-throughput sequencing, untargeted metabolomes, and quantitative microbial element cycling smart chips, we examined the bacterial community structure, soil metabolites, and bacterial functional gene abundances, respectively. We found that bacterial richness (based on Chao1 and Phylogenetic Diversity [PD] indices) was significantly higher in CCY02 and CCY10 than in CCY05. As per principal component analysis (PCA), samples from the continuous monocropping year tended to share more similar species compositions and soil metabolites, and exhibited distinct patterns over time. The results of the Procrustes analysis indicated that alterations in the soil metabolic profiles and bacterial functional genes after long-term continuous cropping were mainly mediated by soil microbial communities (P < 0.05). Moreover, 14 genera mainly contributed to the sample dissimilarities. Of these, five genera were identified as the dominant shared taxa, including Blastococcus, Nocardioides, Sphingomonas, Bacillus, and Solirubrobacter. The continuous cropping of Tibetan barley significantly increased the abundances of genes related to C-degradation (F = 9.25, P = 0.01) and P-cycling (F = 5.35, P = 0.03). N-cycling significantly negatively correlated with bacterial diversity (r = − 0.71, P = 0.01). The co-occurrence network analysis revealed that nine hub genera correlated with most of the functional genes and a hub taxon, Desulfuromonadales, mainly co-occurred with the metabolites via both negative and positive correlations. Collectively, our findings i…
format: application/pdf
format: text/html
creator: Yuan Zhao
creator: Youhua Yao
creator: Hongyan Xu
creator: Zhanling Xie
creator: Jing Guo
creator: Zhifan Qi
creator: Hongchen Jiang
subject: Agricultural Science
subject: Bioinformatics
subject: Microbiology
subject: Mycology
subject: Soil Science
description: doi:10.7717/peerj.13254
publisher: PeerJ Inc.
rights: © 2022 Zhao et al.
abstract: Continuous cropping often leads to an unbalanced soil microbial community, which in turn negatively affects soil functions. However, systematic research of how these effects impact the bacterial composition, microbial functional traits, and soil metabolites is lacking. In the present study, the rhizosphere soil samples of Tibetan barley continuously monocropped for 2 (CCY02), 5 (CCY05), and 10 (CCY10) years were collected. By utilizing 16S high-throughput sequencing, untargeted metabolomes, and quantitative microbial element cycling smart chips, we examined the bacterial community structure, soil metabolites, and bacterial functional gene abundances, respectively. We found that bacterial richness (based on Chao1 and Phylogenetic Diversity [PD] indices) was significantly higher in CCY02 and CCY10 than in CCY05. As per principal component analysis (PCA), samples from the continuous monocropping year tended to share more similar species compositions and soil metabolites, and exhibited distinct patterns over time. The results of the Procrustes analysis indicated that alterations in the soil metabolic profiles and bacterial functional genes after long-term continuous cropping were mainly mediated by soil microbial communities (P < 0.05). Moreover, 14 genera mainly contributed to the sample dissimilarities. Of these, five genera were identified as the dominant shared taxa, including Blastococcus, Nocardioides, Sphingomonas, Bacillus, and Solirubrobacter. The continuous cropping of Tibetan barley significantly increased the abundances of genes related to C-degradation (F = 9.25, P = 0.01) and P-cycling (F = 5.35, P = 0.03). N-cycling significantly negatively correlated with bacterial diversity (r = − 0.71, P = 0.01). The co-occurrence network analysis revealed that nine hub genera correlated with most of the functional genes and a hub taxon, Desulfuromonadales, mainly co-occurred with the metabolites via both negative and positive correlations. Collectively, our findings i…
bibliographic citation: Zhao et al. (2022) Soil metabolomics and bacterial functional traits revealed the responses of rhizosphere soil bacterial community to long-term continuous cropping of Tibetan barley. PeerJ 10:e13254 https://doi.org/10.7717/peerj.13254
date submitted: 2022-01-10
date accepted: 2022-03-22
issued: 2022-04-07
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Zhao
  given name: Yuan
author list: Agent
  family name: Yao
  given name: Youhua
author list: Agent
  family name: Xu
  given name: Hongyan
author list: Agent
  family name: Xie
  given name: Zhanling
author list: Agent
  family name: Guo
  given name: Jing
author list: Agent
  family name: Qi
  given name: Zhifan
author list: Agent
  family name: Jiang
  given name: Hongchen
doi: 10.7717/peerj.13254
volume: 10
issn: 2167-8359
publication name: PeerJ
publication date: 2022-04-07
copyright: ©2022 Zhao et al.
attribution name: Zhao et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359