PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: Factors associated with intention to be vaccinated with the COVID-19 booster dose: a cross-sectional study in Peru
items: On the elephant trails: habitat suitability and connectivity for Asian elephants in eastern Indian landscape
items: An androgen receptor-based signature to predict prognosis and identification of ORC1 as a therapeutical target for prostate adenocarcinoma
items: First record of Apanteles hemara (N.) on Leucinodes orbonalis Guenée and biodiversity of Hymenoptera parasitoids on Brinjal
items: Vocal repertoire of Microhyla nilphamariensis from Delhi and comparison with closely related M. ornata populations from the western coast of India and Sri Lanka
items: Predicting central cervical lymph node metastasis in papillary thyroid microcarcinoma using deep learning
items: Epidemiology and management of Fusarium wilt of Eucalyptus camaldulensis through systemic acquired resistance
items: The relationship between appearance anxiety and depression among students in a medical university in China: a serial multiple mediation model
items: Adaptation and potential culture of wild Amphipods and Mysids as potential live feed in aquaculture: a review
items: The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

Factors associated with intention to be vaccinated with the COVID-19 booster dose: a cross-sectional study in Peru
type: item
type: AcademicArticle
description: Introduction The pandemic of COVID-19 continues to impact people worldwide, with more than 755 million confirmed cases and more than 6.8 million reported deaths. Although two types of treatment, antiviral and immunomodulatory therapy, have been approved to date, vaccination has been the best method to control the spread of the disease. Objective To explore factors associated with the intention to be vaccinated with the COVID-19 booster dose in Peru. Material and Methods Cross-sectional study, using virtual and physical surveys of adults with two or more doses of COVID-19 vaccine, where the dependent variable was the intention to be vaccinated (IBV) with the booster dose. We calculated prevalence ratios with 95% confidence intervals, using generalized linear models of the Poisson family with robust varying, determining associations between sociodemographic, clinical, and booster dose perception variables. Results Data from 924 adults were analyzed. The IBV of the booster doses was 88.1%. A higher prevalence was associated with being male (aPR = 1.05; 95% CI [1.01–1.10]), having a good perception of efficacy and protective effect (PR = 3.69; 95% CI [2.57–5.30]) and belonging to the health sector (PR = 1.10; 95% CI [1.04–1.16]). There was greater acceptance of the recommendation of physicians and other health professionals (aPR = 1.40; 95% CI [1.27–1.55]). Conclusions Factors associated with higher IBV with booster dose include male gender, health sciences, physician recommendation, and good perception of efficacy.
format: application/pdf
format: text/html
creator: Rodrigo Camacho-Neciosup
creator: Ericka N. Balcazar-Huaman
creator: Margarita L. Alvarez-Vilchez
creator: Janith P. De la Cruz-Galán
creator: Yubely Gálvez-Guadalupe
creator: Edwin D. Garcia-Muñoz
creator: Greysi Cerron-Daga
creator: Virgilio E. Failoc-Rojas
creator: Mario J. Valladares-Garrido
subject: Global Health
subject: Immunology
subject: COVID-19
description: doi:10.7717/peerj.16727
publisher: PeerJ Inc.
rights: © 2024 Camacho-Neciosup et al.
abstract: Introduction The pandemic of COVID-19 continues to impact people worldwide, with more than 755 million confirmed cases and more than 6.8 million reported deaths. Although two types of treatment, antiviral and immunomodulatory therapy, have been approved to date, vaccination has been the best method to control the spread of the disease. Objective To explore factors associated with the intention to be vaccinated with the COVID-19 booster dose in Peru. Material and Methods Cross-sectional study, using virtual and physical surveys of adults with two or more doses of COVID-19 vaccine, where the dependent variable was the intention to be vaccinated (IBV) with the booster dose. We calculated prevalence ratios with 95% confidence intervals, using generalized linear models of the Poisson family with robust varying, determining associations between sociodemographic, clinical, and booster dose perception variables. Results Data from 924 adults were analyzed. The IBV of the booster doses was 88.1%. A higher prevalence was associated with being male (aPR = 1.05; 95% CI [1.01–1.10]), having a good perception of efficacy and protective effect (PR = 3.69; 95% CI [2.57–5.30]) and belonging to the health sector (PR = 1.10; 95% CI [1.04–1.16]). There was greater acceptance of the recommendation of physicians and other health professionals (aPR = 1.40; 95% CI [1.27–1.55]). Conclusions Factors associated with higher IBV with booster dose include male gender, health sciences, physician recommendation, and good perception of efficacy.
bibliographic citation: Camacho-Neciosup et al. (2024) Factors associated with intention to be vaccinated with the COVID-19 booster dose: a cross-sectional study in Peru. PeerJ 12:e16727 https://doi.org/10.7717/peerj.16727
date submitted: 2023-07-12
date accepted: 2023-12-05
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Camacho-Neciosup
  given name: Rodrigo
author list: Agent
  family name: Balcazar-Huaman
  given name: Ericka N.
author list: Agent
  family name: Alvarez-Vilchez
  given name: Margarita L.
author list: Agent
  family name: De la Cruz-Galán
  given name: Janith P.
author list: Agent
  family name: Gálvez-Guadalupe
  given name: Yubely
author list: Agent
  family name: Garcia-Muñoz
  given name: Edwin D.
author list: Agent
  family name: Cerron-Daga
  given name: Greysi
author list: Agent
  family name: Failoc-Rojas
  given name: Virgilio E.
author list: Agent
  family name: Valladares-Garrido
  given name: Mario J.
doi: 10.7717/peerj.16727
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: ©2024 Camacho-Neciosup et al.
attribution name: Camacho-Neciosup et al.

On the elephant trails: habitat suitability and connectivity for Asian elephants in eastern Indian landscape
type: item
type: AcademicArticle
description: Identifying suitable habitats and conserving corridors are crucial to the long-term conservation of large and conflict-prone animals. Being a flagship species, survival of Asian elephants is threatened by human-induced mortality and habitat modification. We aimed to assess the habitat suitability and connectivity of the Asian elephant Elephas maximus Linnaeus, 1758 habitat in the state of Odisha in eastern India. We followed the ensemble of spatial prediction models using species presence data and five environmental variables. We used least-cost path and circuit theory approaches to identify the spatial connectivity between core habitats for Asian elephants. The results revealed that normalized difference vegetation index (NDVI; variable importance 42%) and terrain ruggedness (19%) are the most influential variables for predicting habitat suitability of species within the study area. Our habitat suitability map estimated 14.6% of Odisha’s geographical area (c. 22,442 km2) as highly suitable and 13.3% (c. 20,464 km2) as moderate highly suitable. We identified 58 potential linkages to maintain the habitat connectivity across study area. Furthermore, we identified pinch points, bottlenecks, and high centrality links between core habitats. Our study offers management implications for long-term landscape conservation for Asian elephants in Odisha and highlights priority zones that can help maintain spatial links between elephant habitats.
format: application/pdf
format: text/html
creator: Himanshu Shekhar Palei
creator: Ashish Kumar Jangid
creator: Dhamdhere Dhanraj Hanumant
creator: Nimain Charan Palei
creator: Arun Kumar Mishra
subject: Biogeography
subject: Conservation Biology
subject: Ecology
subject: Zoology
subject: Spatial and Geographic Information Science
description: doi:10.7717/peerj.16746
publisher: PeerJ Inc.
rights: © 2024 Palei et al.
abstract: Identifying suitable habitats and conserving corridors are crucial to the long-term conservation of large and conflict-prone animals. Being a flagship species, survival of Asian elephants is threatened by human-induced mortality and habitat modification. We aimed to assess the habitat suitability and connectivity of the Asian elephant Elephas maximus Linnaeus, 1758 habitat in the state of Odisha in eastern India. We followed the ensemble of spatial prediction models using species presence data and five environmental variables. We used least-cost path and circuit theory approaches to identify the spatial connectivity between core habitats for Asian elephants. The results revealed that normalized difference vegetation index (NDVI; variable importance 42%) and terrain ruggedness (19%) are the most influential variables for predicting habitat suitability of species within the study area. Our habitat suitability map estimated 14.6% of Odisha’s geographical area (c. 22,442 km2) as highly suitable and 13.3% (c. 20,464 km2) as moderate highly suitable. We identified 58 potential linkages to maintain the habitat connectivity across study area. Furthermore, we identified pinch points, bottlenecks, and high centrality links between core habitats. Our study offers management implications for long-term landscape conservation for Asian elephants in Odisha and highlights priority zones that can help maintain spatial links between elephant habitats.
bibliographic citation: Palei et al. (2024) On the elephant trails: habitat suitability and connectivity for Asian elephants in eastern Indian landscape. PeerJ 12:e16746 https://doi.org/10.7717/peerj.16746
date submitted: 2023-09-05
date accepted: 2023-12-11
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Palei
  given name: Himanshu Shekhar
author list: Agent
  family name: Jangid
  given name: Ashish Kumar
author list: Agent
  family name: Hanumant
  given name: Dhamdhere Dhanraj
author list: Agent
  family name: Palei
  given name: Nimain Charan
author list: Agent
  family name: Mishra
  given name: Arun Kumar
doi: 10.7717/peerj.16746
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: ©2024 Palei et al.
attribution name: Palei et al.

An androgen receptor-based signature to predict prognosis and identification of ORC1 as a therapeutical target for prostate adenocarcinoma
type: item
type: AcademicArticle
description: Background Aberrant activation of androgen receptor (AR) signaling plays a crucial role in the progression of prostate adenocarcinoma (PRAD) and contributes significantly to the development of enzalutamide resistance. In this study, we aimed to identify a novel AR-driven signature that can predict prognosis and endows potentially reveal novel therapeutic targets for PRAD. Methods The Seurat package was used to preprocess the single-cell RNA sequencing (scRNA-seq). Differentially expressed genes were visualized using limma and pheamap packages. LASSO and multi-variate Cox regression models were established using glmnet package. The package “Consensus Cluster Plus” was utilized to perform the consensus clustering analysis. The biological roles of origin recognition complex subunit 1 (ORC1) in PRAD were determined by gain- and loss-of-function studies in vitro and in vivo. Result We characterized the scRNA-seq data from GSE99795 and identified 10 AR-associated genes (ARGs). The ARGs model was trained and validated in internal and external cohorts. The ARGs were identified as an independent hazard factor in PRAD and correlated with clinical risk characteristics. In addition, the ARGs were found to be correlated with somatic tumor mutation burden (TMB) levels. Two groups that have distinct prognostic and molecular features were identified through consensus clustering analysis. ORC1 was identified as a critical target among these ARGs, and it ORC1 promoted proliferation and stem-like properties of PRAD cells. Chromatin immunoprecipitation (ChIP)-qPCR assay confirmed that AR could directly bind the promoter of ORC1. Activated AR/ORC1 axis contributed to enzalutamide resistance, and targeting ORC1 rendered PRAD cells more susceptible to enzalutamide. Conclusions This study defines an AR-driven signature that AR activates ORC1 expressions to promote PRAD progression and enzalutamide resistance, which may provide novel targets for PRAD treatment.
format: application/pdf
format: text/html
creator: Linjin Li
creator: Dake Chen
creator: Xiang Chen
creator: Jianlong Zhu
creator: Wenshuo Bao
creator: Chengpeng Li
creator: Feilong Miao
creator: Rui Feng
subject: Bioinformatics
subject: Cell Biology
subject: Molecular Biology
subject: Oncology
subject: Medical Genetics
description: doi:10.7717/peerj.16850
publisher: PeerJ Inc.
rights: © 2024 Li et al.
abstract: Background Aberrant activation of androgen receptor (AR) signaling plays a crucial role in the progression of prostate adenocarcinoma (PRAD) and contributes significantly to the development of enzalutamide resistance. In this study, we aimed to identify a novel AR-driven signature that can predict prognosis and endows potentially reveal novel therapeutic targets for PRAD. Methods The Seurat package was used to preprocess the single-cell RNA sequencing (scRNA-seq). Differentially expressed genes were visualized using limma and pheamap packages. LASSO and multi-variate Cox regression models were established using glmnet package. The package “Consensus Cluster Plus” was utilized to perform the consensus clustering analysis. The biological roles of origin recognition complex subunit 1 (ORC1) in PRAD were determined by gain- and loss-of-function studies in vitro and in vivo. Result We characterized the scRNA-seq data from GSE99795 and identified 10 AR-associated genes (ARGs). The ARGs model was trained and validated in internal and external cohorts. The ARGs were identified as an independent hazard factor in PRAD and correlated with clinical risk characteristics. In addition, the ARGs were found to be correlated with somatic tumor mutation burden (TMB) levels. Two groups that have distinct prognostic and molecular features were identified through consensus clustering analysis. ORC1 was identified as a critical target among these ARGs, and it ORC1 promoted proliferation and stem-like properties of PRAD cells. Chromatin immunoprecipitation (ChIP)-qPCR assay confirmed that AR could directly bind the promoter of ORC1. Activated AR/ORC1 axis contributed to enzalutamide resistance, and targeting ORC1 rendered PRAD cells more susceptible to enzalutamide. Conclusions This study defines an AR-driven signature that AR activates ORC1 expressions to promote PRAD progression and enzalutamide resistance, which may provide novel targets for PRAD treatment.
bibliographic citation: Li et al. (2024) An androgen receptor-based signature to predict prognosis and identification of ORC1 as a therapeutical target for prostate adenocarcinoma. PeerJ 12:e16850 https://doi.org/10.7717/peerj.16850
date submitted: 2023-04-27
date accepted: 2024-01-08
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Li
  given name: Linjin
author list: Agent
  family name: Chen
  given name: Dake
author list: Agent
  family name: Chen
  given name: Xiang
author list: Agent
  family name: Zhu
  given name: Jianlong
author list: Agent
  family name: Bao
  given name: Wenshuo
author list: Agent
  family name: Li
  given name: Chengpeng
author list: Agent
  family name: Miao
  given name: Feilong
author list: Agent
  family name: Feng
  given name: Rui
doi: 10.7717/peerj.16850
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: © 2024 Li et al.
attribution name: Li et al.

First record of Apanteles hemara (N.) on Leucinodes orbonalis Guenée and biodiversity of Hymenoptera parasitoids on Brinjal
type: item
type: AcademicArticle
description: The brinjal fruit and shoot borer (BFSB), Leucinodes orbonalis Guenée (Lepidoptera: Crambidae), is a very detrimental pest that causes significant economic losses to brinjal crop worldwide. Infested brinjal fruits were collected from vegetable fields located at the ICAR-Indian Agricultural Research Institute (ICAR-IARI), New Delhi, India, during two consecutive seasons (2021–2022). The larvae of the pest were brought to the laboratory and reared under controlled conditions of 25 ± 0.5 °C and 70 ± 5% relative humidity, for the emergence of parasitoids. In addition, the survey of Hymenoptera parasitoids in brinjal was conducted utilizing a sweep net and yellow pan trap over the course of two seasons. The results reveal that five parasitoid species were emerged from L. orbonalis viz., Apanteles hemara Nixon, 1965, Bracon greeni Ashmead 1896 (Hymenoptera: Braconidae), Goryphus nursei (Cameron, 1907), Trathala flavoorbitalis (Cameron, 1907) (Hymenoptera: Ichneumonidae) and Spalangia gemina Boucek 1963 (Hymenoptera: Spalangiidae). Out of these, A. hemara and S. gemina were documented as new occurrences in Delhi. Additionally, A. hemara was recorded for the first time as a parasite on L. orbonalis. Trathala flavoorbitalis was observed during both seasons and exhibited higher parasitism reaching 15.55% and 18.46% in July and August 2022, respectively. However, the average parasitism (%) recorded by A. hemara, B. greeni, G. nursei, T. flavoorbitalis and S. gemina was 3.10%, 1.76%, 1.10%, 9.28% and 1.20% respectively. Furthermore, the findings showed a significant (p ≤ 0.01) strongly positive correlation between fruit infestation (%) by L. orbonalis and parasitism (%). The survey indicates the presence of a broad group (19 families and 60 species) of Hymenoptera parasitoids in the brinjal crop ecosystem in Delhi which could be valuable in biological control. In light of these results, this study revealed that A. hemara and other parasitoids identified in this study alongside …
format: application/pdf
format: text/html
creator: Hager M. M. Saleh
creator: Areej A. Al-Khalaf
creator: Maha Abdullah Alwaili
creator: Debjani Dey
subject: Agricultural Science
subject: Biodiversity
subject: Ecology
subject: Entomology
subject: Zoology
description: doi:10.7717/peerj.16870
publisher: PeerJ Inc.
rights: © 2024 Saleh et al.
abstract: The brinjal fruit and shoot borer (BFSB), Leucinodes orbonalis Guenée (Lepidoptera: Crambidae), is a very detrimental pest that causes significant economic losses to brinjal crop worldwide. Infested brinjal fruits were collected from vegetable fields located at the ICAR-Indian Agricultural Research Institute (ICAR-IARI), New Delhi, India, during two consecutive seasons (2021–2022). The larvae of the pest were brought to the laboratory and reared under controlled conditions of 25 ± 0.5 °C and 70 ± 5% relative humidity, for the emergence of parasitoids. In addition, the survey of Hymenoptera parasitoids in brinjal was conducted utilizing a sweep net and yellow pan trap over the course of two seasons. The results reveal that five parasitoid species were emerged from L. orbonalis viz., Apanteles hemara Nixon, 1965, Bracon greeni Ashmead 1896 (Hymenoptera: Braconidae), Goryphus nursei (Cameron, 1907), Trathala flavoorbitalis (Cameron, 1907) (Hymenoptera: Ichneumonidae) and Spalangia gemina Boucek 1963 (Hymenoptera: Spalangiidae). Out of these, A. hemara and S. gemina were documented as new occurrences in Delhi. Additionally, A. hemara was recorded for the first time as a parasite on L. orbonalis. Trathala flavoorbitalis was observed during both seasons and exhibited higher parasitism reaching 15.55% and 18.46% in July and August 2022, respectively. However, the average parasitism (%) recorded by A. hemara, B. greeni, G. nursei, T. flavoorbitalis and S. gemina was 3.10%, 1.76%, 1.10%, 9.28% and 1.20% respectively. Furthermore, the findings showed a significant (p ≤ 0.01) strongly positive correlation between fruit infestation (%) by L. orbonalis and parasitism (%). The survey indicates the presence of a broad group (19 families and 60 species) of Hymenoptera parasitoids in the brinjal crop ecosystem in Delhi which could be valuable in biological control. In light of these results, this study revealed that A. hemara and other parasitoids identified in this study alongside …
bibliographic citation: Saleh et al. (2024) First record of Apanteles hemara (N.) on Leucinodes orbonalis Guenée and biodiversity of Hymenoptera parasitoids on Brinjal. PeerJ 12:e16870 https://doi.org/10.7717/peerj.16870
date submitted: 2023-07-24
date accepted: 2024-01-10
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Saleh
  given name: Hager M. M.
author list: Agent
  family name: Al-Khalaf
  given name: Areej A.
author list: Agent
  family name: Alwaili
  given name: Maha Abdullah
author list: Agent
  family name: Dey
  given name: Debjani
doi: 10.7717/peerj.16870
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: © 2024 Saleh et al.
attribution name: Saleh et al.

Vocal repertoire of Microhyla nilphamariensis from Delhi and comparison with closely related M. ornata populations from the western coast of India and Sri Lanka
type: item
type: AcademicArticle
description: Advertisement calls in frogs have evolved to be species-specific signals of recognition and are therefore considered an essential component of integrative taxonomic approaches to identify species and delineate their distribution range. The species rich genus Microhyla is a particularly challenging group for species identification, discovery and conservation management due to the small size, conserved morphology and wide distribution of its members, necessitating the need for a thorough description of their vocalization. In this study, we provide quantitative description of the vocal behaviour of Microhyla nilphamariensis, a widely distributed south Asian species, from Delhi, India, based on call recordings of 18 individuals and assessment of 21 call properties. Based on the properties measured acrossed 360 calls, we find that a typical advertisement call of M. nilphamariensis lasts for 393.5 ± 57.5 ms, has 17 pulses on average and produce pulses at rate of 39 pulses/s. The overall call dominant frequency was found to be 2.8 KHz and the call spectrum consisted of two dominant frequency peaks centered at 1.6 KHz and 3.6 KHz, ranging between 1.5–4.1 KHz. Apart from its typical advertisement call, our study also reveals the presence of three ‘rare’ call types, previously unreported in this species. We describe variability in call properties and discuss their relation to body size and temperature. We found that overall dominant frequency 1 (spectral property) was found to be correlated with body size, while first pulse period (temporal property) was found to be correlated with temperature. Further, we compare the vocal repertoire of M. nilphamariensis with that of the congener Microhyla ornata from the western coast of India and Sri Lanka and also compare the call properties of these two populations of M. ornata to investigate intra-specific call variation. We find statistically significant differentiation in their acoustic repertoire in both cases. Based on 18 call prop…
format: application/pdf
format: text/html
creator: Megha Srigyan
creator: Abdus Samad
creator: Abhishek Singh
creator: Jyotsna Karan
creator: Abhishek Chandra
creator: Pooja Gokhale Sinha
creator: Vineeth Kumar
creator: Sandeep Das
creator: Ashish Thomas
creator: Robin Suyesh
subject: Animal Behavior
subject: Biodiversity
subject: Zoology
description: doi:10.7717/peerj.16903
publisher: PeerJ Inc.
rights: © 2024 Srigyan et al.
abstract: Advertisement calls in frogs have evolved to be species-specific signals of recognition and are therefore considered an essential component of integrative taxonomic approaches to identify species and delineate their distribution range. The species rich genus Microhyla is a particularly challenging group for species identification, discovery and conservation management due to the small size, conserved morphology and wide distribution of its members, necessitating the need for a thorough description of their vocalization. In this study, we provide quantitative description of the vocal behaviour of Microhyla nilphamariensis, a widely distributed south Asian species, from Delhi, India, based on call recordings of 18 individuals and assessment of 21 call properties. Based on the properties measured acrossed 360 calls, we find that a typical advertisement call of M. nilphamariensis lasts for 393.5 ± 57.5 ms, has 17 pulses on average and produce pulses at rate of 39 pulses/s. The overall call dominant frequency was found to be 2.8 KHz and the call spectrum consisted of two dominant frequency peaks centered at 1.6 KHz and 3.6 KHz, ranging between 1.5–4.1 KHz. Apart from its typical advertisement call, our study also reveals the presence of three ‘rare’ call types, previously unreported in this species. We describe variability in call properties and discuss their relation to body size and temperature. We found that overall dominant frequency 1 (spectral property) was found to be correlated with body size, while first pulse period (temporal property) was found to be correlated with temperature. Further, we compare the vocal repertoire of M. nilphamariensis with that of the congener Microhyla ornata from the western coast of India and Sri Lanka and also compare the call properties of these two populations of M. ornata to investigate intra-specific call variation. We find statistically significant differentiation in their acoustic repertoire in both cases. Based on 18 call prop…
bibliographic citation: Srigyan et al. (2024) Vocal repertoire of Microhyla nilphamariensis from Delhi and comparison with closely related M. ornata populations from the western coast of India and Sri Lanka. PeerJ 12:e16903 https://doi.org/10.7717/peerj.16903
date submitted: 2021-09-23
date accepted: 2024-01-17
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Srigyan
  given name: Megha
author list: Agent
  family name: Samad
  given name: Abdus
author list: Agent
  family name: Singh
  given name: Abhishek
author list: Agent
  family name: Karan
  given name: Jyotsna
author list: Agent
  family name: Chandra
  given name: Abhishek
author list: Agent
  family name: Sinha
  given name: Pooja Gokhale
author list: Agent
  family name: Kumar
  given name: Vineeth
author list: Agent
  family name: Das
  given name: Sandeep
author list: Agent
  family name: Thomas
  given name: Ashish
author list: Agent
  family name: Suyesh
  given name: Robin
doi: 10.7717/peerj.16903
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: ©2024 Srigyan et al.
attribution name: Srigyan et al.

Predicting central cervical lymph node metastasis in papillary thyroid microcarcinoma using deep learning
type: item
type: AcademicArticle
description: Background The aim of this study is to design a deep learning (DL) model to preoperatively predict the occurrence of central lymph node metastasis (CLNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods This research collected preoperative ultrasound (US) images and clinical factors of 611 PTMC patients. The clinical factors were analyzed using multivariate regression. Then, a DL model based on US images and clinical factors was developed to preoperatively predict CLNM. The model’s efficacy was evaluated using the receiver operating characteristic (ROC) curve, along with accuracy, sensitivity, specificity, and the F1 score. Results The multivariate analysis indicated an independent correlation factors including age ≥55 (OR = 0.309, p < 0.001), tumor diameter (OR = 2.551, p = 0.010), macrocalcifications (OR = 1.832, p = 0.002), and capsular invasion (OR = 1.977, p = 0.005). The suggested DL model utilized US images achieved an average area under the curve (AUC) of 0.65, slightly outperforming the model that employed traditional clinical factors (AUC = 0.64). Nevertheless, the model that incorporated both of them did not enhance prediction accuracy (AUC = 0.63). Conclusions The suggested approach offers a reference for the treatment and supervision of PTMC. Among three models used in this study, the deep model relied generally more on image modalities than the data modality of clinic records when making the predictions.
format: application/pdf
format: text/html
creator: Yu Wang
creator: Hai-Long Tan
creator: Sai-Li Duan
creator: Ning Li
creator: Lei Ai
creator: Shi Chang
subject: Computational Biology
subject: Oncology
subject: Computational Science
description: doi:10.7717/peerj.16952
publisher: PeerJ Inc.
rights: © 2024 Wang et al.
abstract: Background The aim of this study is to design a deep learning (DL) model to preoperatively predict the occurrence of central lymph node metastasis (CLNM) in patients with papillary thyroid microcarcinoma (PTMC). Methods This research collected preoperative ultrasound (US) images and clinical factors of 611 PTMC patients. The clinical factors were analyzed using multivariate regression. Then, a DL model based on US images and clinical factors was developed to preoperatively predict CLNM. The model’s efficacy was evaluated using the receiver operating characteristic (ROC) curve, along with accuracy, sensitivity, specificity, and the F1 score. Results The multivariate analysis indicated an independent correlation factors including age ≥55 (OR = 0.309, p < 0.001), tumor diameter (OR = 2.551, p = 0.010), macrocalcifications (OR = 1.832, p = 0.002), and capsular invasion (OR = 1.977, p = 0.005). The suggested DL model utilized US images achieved an average area under the curve (AUC) of 0.65, slightly outperforming the model that employed traditional clinical factors (AUC = 0.64). Nevertheless, the model that incorporated both of them did not enhance prediction accuracy (AUC = 0.63). Conclusions The suggested approach offers a reference for the treatment and supervision of PTMC. Among three models used in this study, the deep model relied generally more on image modalities than the data modality of clinic records when making the predictions.
bibliographic citation: Wang et al. (2024) Predicting central cervical lymph node metastasis in papillary thyroid microcarcinoma using deep learning. PeerJ 12:e16952 https://doi.org/10.7717/peerj.16952
date submitted: 2023-11-03
date accepted: 2024-01-24
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Wang
  given name: Yu
author list: Agent
  family name: Tan
  given name: Hai-Long
author list: Agent
  family name: Duan
  given name: Sai-Li
author list: Agent
  family name: Li
  given name: Ning
author list: Agent
  family name: Ai
  given name: Lei
author list: Agent
  family name: Chang
  given name: Shi
doi: 10.7717/peerj.16952
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: ©2024 Wang et al.
attribution name: Wang et al.

Epidemiology and management of Fusarium wilt of Eucalyptus camaldulensis through systemic acquired resistance
type: item
type: AcademicArticle
description: Eucalyptus camaldulensis is a multifunctional tree and is globally used for the reclamation of problematic lands. Eucalyptus camaldulensis is prone to attack by a number of pathogens, but the most important threat is the Fusarium wilt (Fusarium oxysporum). Keeping in view the importance of E. camaldulensis and to manage this disease, five plant activators, i.e., salicylic acid (C7H6O3), benzoic acid (C7H6O2), citric acid (C6H8O7), dipotassium phosphate (K2HPO4), monopotassium phosphate (KH2PO4) and nutritional mixture namely Compound (NPK) and nutriotop (Fe, Zn, Cu, B, Mn) were evaluated in the Fusarium infested field under RCBD in the Research Area, Department of Forestry and Range Management, University of Agriculture, Faisalabad (UAF). Among plant activators, salicylic acid and a combination of compound + nutriotop exhibited the lowest disease incidence and enhanced fresh and dry weight of leaves compared to other treatments and control. Results of the environmental study indicated maximum disease incidence between 35–40 °C (max. T), 6–25 °C (mini. T), 70–80% relative humidity and 1.5–2.5 km/h wind speed while pan evaporation expressed weak correlation with disease development. It was concluded that Fusarium wilt of Eucalyptus camaldulensis could be managed through activation of the basal defense system of the host plant with provision of salicylic acid and balanced nutrition by considering environmental factors. Recent exploration is expected to be helpful for future research efforts on epidemiology and ecologically sound intervention of Fusarium wilt of Eucalyptus camaldulensis.
format: application/pdf
format: text/html
creator: Irfan Ahmad
creator: Komal Mazhar
creator: Muhammad Atiq
creator: Amna Kahtan Khalaf
creator: Muhammad Haroon U. Rashid
creator: Muhammad Asif
creator: Salman Ahmed
creator: Zoha Adil
creator: Amna Fayyaz
creator: Mohammad Khalid Al-Sadoon
creator: Hamad S. Al-Otaibi
subject: Environmental Contamination and Remediation
subject: Environmental Impacts
subject: Forestry
description: doi:10.7717/peerj.17022
publisher: PeerJ Inc.
rights: © 2024 Ahmad et al.
abstract: Eucalyptus camaldulensis is a multifunctional tree and is globally used for the reclamation of problematic lands. Eucalyptus camaldulensis is prone to attack by a number of pathogens, but the most important threat is the Fusarium wilt (Fusarium oxysporum). Keeping in view the importance of E. camaldulensis and to manage this disease, five plant activators, i.e., salicylic acid (C7H6O3), benzoic acid (C7H6O2), citric acid (C6H8O7), dipotassium phosphate (K2HPO4), monopotassium phosphate (KH2PO4) and nutritional mixture namely Compound (NPK) and nutriotop (Fe, Zn, Cu, B, Mn) were evaluated in the Fusarium infested field under RCBD in the Research Area, Department of Forestry and Range Management, University of Agriculture, Faisalabad (UAF). Among plant activators, salicylic acid and a combination of compound + nutriotop exhibited the lowest disease incidence and enhanced fresh and dry weight of leaves compared to other treatments and control. Results of the environmental study indicated maximum disease incidence between 35–40 °C (max. T), 6–25 °C (mini. T), 70–80% relative humidity and 1.5–2.5 km/h wind speed while pan evaporation expressed weak correlation with disease development. It was concluded that Fusarium wilt of Eucalyptus camaldulensis could be managed through activation of the basal defense system of the host plant with provision of salicylic acid and balanced nutrition by considering environmental factors. Recent exploration is expected to be helpful for future research efforts on epidemiology and ecologically sound intervention of Fusarium wilt of Eucalyptus camaldulensis.
bibliographic citation: Ahmad et al. (2024) Epidemiology and management of Fusarium wilt of Eucalyptus camaldulensis through systemic acquired resistance. PeerJ 12:e17022 https://doi.org/10.7717/peerj.17022
date submitted: 2023-09-05
date accepted: 2024-02-06
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Ahmad
  given name: Irfan
author list: Agent
  family name: Mazhar
  given name: Komal
author list: Agent
  family name: Atiq
  given name: Muhammad
author list: Agent
  family name: Khalaf
  given name: Amna Kahtan
author list: Agent
  family name: Rashid
  given name: Muhammad Haroon U.
author list: Agent
  family name: Asif
  given name: Muhammad
author list: Agent
  family name: Ahmed
  given name: Salman
author list: Agent
  family name: Adil
  given name: Zoha
author list: Agent
  family name: Fayyaz
  given name: Amna
author list: Agent
  family name: Al-Sadoon
  given name: Mohammad Khalid
author list: Agent
  family name: Al-Otaibi
  given name: Hamad S.
doi: 10.7717/peerj.17022
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: © 2024 Ahmad et al.
attribution name: Ahmad et al.

The relationship between appearance anxiety and depression among students in a medical university in China: a serial multiple mediation model
type: item
type: AcademicArticle
description: Background Appearance anxiety and depression have become common and global public health problems worldwide, especially among adolescents. However, few studies have revealed the mechanisms between them. This study aimed to explore the multiple mediating roles of interpersonal sensitivity and social support between appearance anxiety and depression among medical college students. Methods With 13 invalid samples excluded, 724 college students participated in our survey and completed questionnaires. The average age of 724 samples was 19.8 ± 2.02 including freshman to senior year and graduate school and above; 31.9% of the participants were male and 68.1% were female. SPSS 25.0 and Hayes’ PROCESS macro were used for statistical description, correlation analysis and built multiple mediation models. Results Appearance anxiety can not only directly affect depression, but also indirectly affect depression through three significant mediating pathways: (1) IS (B = 0.106, 95% CI [0.082–0.132]), which accounted for 49.77% of the total effect, (2) SS (B = 0.018, 95% CI [0.008–0.031]), which accounted for 8.45% of the total effect, and (3) IS and SS (B = 0.008, 95% CI [0.003–0.014]), which accounted for 3.76% of the total effect. And the total mediating effect was 61.97%. Limitations It is a cross-sectional research method and the causal relationship is unclear. Conclusions This study found that lower interpersonal sensitivity and higher social support can effectively reduce depression caused by appearance anxiety among college students. The schools and relevant departments should take measures to reduce the interpersonal sensitivity of college students and establish reliable social support, so as to reduce the occurrence of depression.
format: application/pdf
format: text/html
creator: Xiaobing Xian
creator: Tengfei Niu
creator: Yu Zhang
creator: Xilin Zhou
creator: Xinxin Wang
creator: Xin Du
creator: Linhan Qu
creator: Binyi Mao
creator: Ying He
creator: Xiyu Chen
creator: Mengliang Ye
subject: Psychiatry and Psychology
subject: Public Health
subject: Mental Health
description: doi:10.7717/peerj.17090
publisher: PeerJ Inc.
rights: © 2024 Xian et al.
abstract: Background Appearance anxiety and depression have become common and global public health problems worldwide, especially among adolescents. However, few studies have revealed the mechanisms between them. This study aimed to explore the multiple mediating roles of interpersonal sensitivity and social support between appearance anxiety and depression among medical college students. Methods With 13 invalid samples excluded, 724 college students participated in our survey and completed questionnaires. The average age of 724 samples was 19.8 ± 2.02 including freshman to senior year and graduate school and above; 31.9% of the participants were male and 68.1% were female. SPSS 25.0 and Hayes’ PROCESS macro were used for statistical description, correlation analysis and built multiple mediation models. Results Appearance anxiety can not only directly affect depression, but also indirectly affect depression through three significant mediating pathways: (1) IS (B = 0.106, 95% CI [0.082–0.132]), which accounted for 49.77% of the total effect, (2) SS (B = 0.018, 95% CI [0.008–0.031]), which accounted for 8.45% of the total effect, and (3) IS and SS (B = 0.008, 95% CI [0.003–0.014]), which accounted for 3.76% of the total effect. And the total mediating effect was 61.97%. Limitations It is a cross-sectional research method and the causal relationship is unclear. Conclusions This study found that lower interpersonal sensitivity and higher social support can effectively reduce depression caused by appearance anxiety among college students. The schools and relevant departments should take measures to reduce the interpersonal sensitivity of college students and establish reliable social support, so as to reduce the occurrence of depression.
bibliographic citation: Xian et al. (2024) The relationship between appearance anxiety and depression among students in a medical university in China: a serial multiple mediation model. PeerJ 12:e17090 https://doi.org/10.7717/peerj.17090
date submitted: 2023-07-26
date accepted: 2024-02-20
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Xian
  given name: Xiaobing
author list: Agent
  family name: Niu
  given name: Tengfei
author list: Agent
  family name: Zhang
  given name: Yu
author list: Agent
  family name: Zhou
  given name: Xilin
author list: Agent
  family name: Wang
  given name: Xinxin
author list: Agent
  family name: Du
  given name: Xin
author list: Agent
  family name: Qu
  given name: Linhan
author list: Agent
  family name: Mao
  given name: Binyi
author list: Agent
  family name: He
  given name: Ying
author list: Agent
  family name: Chen
  given name: Xiyu
author list: Agent
  family name: Ye
  given name: Mengliang
doi: 10.7717/peerj.17090
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: © 2024 Xian et al.
attribution name: Xian et al.

Adaptation and potential culture of wild Amphipods and Mysids as potential live feed in aquaculture: a review
type: item
type: AcademicArticle
description: Live foods such as phytoplankton and zooplankton are essential food sources in aquaculture. Due to their small size, they are suitable for newly hatched larvae. Artemia and rotifer are commonly used live feeds in aquaculture; each feed has a limited dietary value, which is unsuitable for all cultured species. Whereas, copepod and cladocerans species exhibit favorable characteristics that make them viable candidates as sources of essential nutrients for hatchery operations. Due to their jerking movements, it stimulates the feeding response of fish larvae, and their various sizes make them suitable for any fish and crustacean. Even though Artemia is the best live feed due to its proficient nutritional quality, the cost is very expensive, which is about half of the production cost. A recent study suggests the use of amphipods and mysids as alternative live feeds in aquaculture. High nutritional value is present in amphipods and mysids, especially proteins, lipids, and essential fatty acids that are required by fish larvae during early development. Amphipods and mysids are considered abundant in the aquatic ecosystem and have been used by researchers in water toxicity studies. However, the culture of amphipods and mysids has been poorly studied. There is only a small-scale culture under laboratory conditions for scientific research that has been performed. Thus, further research is required to find a way to improve the mass culture of amphipods and mysids that can benefit the aquaculture industry. This review article is intended to provide the available information on amphipods and mysids, including reproductive biology, culture method, nutritional value, feed enhancement, and the importance of them as potential live feed in aquaculture. This article is useful as a guideline for researchers, hatchery operators, and farmers.
format: application/pdf
format: text/html
creator: Hidayu Suhaimi
creator: Muhammad Irfan Abdul Rahman
creator: Aisyah Ashaari
creator: Mhd Ikhwanuddin
creator: Nadiah Wan Rasdi
subject: Aquaculture, Fisheries and Fish Science
subject: Marine Biology
subject: Freshwater Biology
subject: Aquatic and Marine Chemistry
subject: Environmental Impacts
description: doi:10.7717/peerj.17092
publisher: PeerJ Inc.
rights: © 2024 Suhaimi et al.
abstract: Live foods such as phytoplankton and zooplankton are essential food sources in aquaculture. Due to their small size, they are suitable for newly hatched larvae. Artemia and rotifer are commonly used live feeds in aquaculture; each feed has a limited dietary value, which is unsuitable for all cultured species. Whereas, copepod and cladocerans species exhibit favorable characteristics that make them viable candidates as sources of essential nutrients for hatchery operations. Due to their jerking movements, it stimulates the feeding response of fish larvae, and their various sizes make them suitable for any fish and crustacean. Even though Artemia is the best live feed due to its proficient nutritional quality, the cost is very expensive, which is about half of the production cost. A recent study suggests the use of amphipods and mysids as alternative live feeds in aquaculture. High nutritional value is present in amphipods and mysids, especially proteins, lipids, and essential fatty acids that are required by fish larvae during early development. Amphipods and mysids are considered abundant in the aquatic ecosystem and have been used by researchers in water toxicity studies. However, the culture of amphipods and mysids has been poorly studied. There is only a small-scale culture under laboratory conditions for scientific research that has been performed. Thus, further research is required to find a way to improve the mass culture of amphipods and mysids that can benefit the aquaculture industry. This review article is intended to provide the available information on amphipods and mysids, including reproductive biology, culture method, nutritional value, feed enhancement, and the importance of them as potential live feed in aquaculture. This article is useful as a guideline for researchers, hatchery operators, and farmers.
bibliographic citation: Suhaimi et al. (2024) Adaptation and potential culture of wild Amphipods and Mysids as potential live feed in aquaculture: a review. PeerJ 12:e17092 https://doi.org/10.7717/peerj.17092
date submitted: 2023-07-31
date accepted: 2024-02-20
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Suhaimi
  given name: Hidayu
author list: Agent
  family name: Abdul Rahman
  given name: Muhammad Irfan
author list: Agent
  family name: Ashaari
  given name: Aisyah
author list: Agent
  family name: Ikhwanuddin
  given name: Mhd
author list: Agent
  family name: Wan Rasdi
  given name: Nadiah
doi: 10.7717/peerj.17092
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: © 2024 Suhaimi et al.
attribution name: Suhaimi et al.

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target
type: item
type: AcademicArticle
description: Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.
format: application/pdf
format: text/html
creator: Mufei Wang
creator: Juanjuan Zhao
creator: Jiuxia Chen
creator: Teng Long
creator: Mengwei Xu
creator: Tingting Luo
creator: Qingya Che
creator: Yihuai He
creator: Delin Xu
subject: Biochemistry
subject: Molecular Biology
subject: Immunology
subject: Infectious Diseases
subject: Metabolic Sciences
description: doi:10.7717/peerj.17094
publisher: PeerJ Inc.
rights: © 2024 Wang et al.
abstract: Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.
bibliographic citation: Wang et al. (2024) The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target. PeerJ 12:e17094 https://doi.org/10.7717/peerj.17094
date submitted: 2023-07-21
date accepted: 2024-02-20
issued: 2024-03-29
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Wang
  given name: Mufei
author list: Agent
  family name: Zhao
  given name: Juanjuan
author list: Agent
  family name: Chen
  given name: Jiuxia
author list: Agent
  family name: Long
  given name: Teng
author list: Agent
  family name: Xu
  given name: Mengwei
author list: Agent
  family name: Luo
  given name: Tingting
author list: Agent
  family name: Che
  given name: Qingya
author list: Agent
  family name: He
  given name: Yihuai
author list: Agent
  family name: Xu
  given name: Delin
doi: 10.7717/peerj.17094
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-03-29
copyright: ©2024 Wang et al.
attribution name: Wang et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359