PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: Cancer prevention recommendations: awareness in a Mexican public hospital
items: Risk factors of bloodstream infection in erythroderma from atopic dermatitis, psoriasis, and drug reactions: a retrospective observational cohort study
items: https://peerj.com/articles/17706
items: Effect of intensity training block on anxiety state and performance in competitive swimmers
items: Do the effects last? A comparison between internal and external focus of attention instructions on golf putting accuracy over multiple days
items: Hypertension in frail older adults: current perspectives
items: Anthropogenic fertilization influences a shift in barley rhizosphere microbial communities
items: Estimation of environment stability for fruit yield and capsaicin content by using two models in Capsicum chinense Jacq. (Ghost Pepper) with multi-year evaluation
items: Identification and validation of calcium extrusion-related genes prognostic signature in colon adenocarcinoma
items: Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma

Cancer prevention recommendations: awareness in a Mexican public hospital
type: item
type: AcademicArticle
description: Background The recommendations of both the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) for the prevention of cancer are important public health tools. These recommendations for the prevention of specific cancers are related to body weight maintenance; physical activity; foods and drinks that promote weight gain; plant foods; foods of animal origin; alcoholic beverages; preservation, processing, and preparation of food; food supplements; and breastfeeding. Methods This study was a descriptive, cross-sectional, retrospective study. All patients provided written informed consent prior to enrollment in the study. Stratified random sampling was carried out with a convenience sample size of ≥280 participants. The characteristics of the participants were investigated using validated questions. Knowledge about the WCRF/AICR recommendations for the primary prevention of cancer was determined using 14 multiple choice questions validated in this study. Group A included participants who answered that cancer can be prevented and that lifestyle is the main factor related to the onset of cancer; the remaining participants were assigned to Group B. The χ2 test and Mann‒Whitney U test were used to determine differences in the groups. A p-value of ≤0.05 was considered statistically significant. A multiple linear regression analysis with gamma response was performed to assess the knowledge score. Results A total of 289 participants were included; 168 (58%) participants were in group A, and 121 (42%) participants were in group B. Using a 0 to 14 scale, the median (P25, P75) number of correct answers was 11 (10, 12). There was no evidence of a difference between groups in sex, relationship status, literacy skills, years of education, occupation, monthly income per person, and BMI. Most of the participants reported that they did not consume tobacco (n = 259/289) or alcohol (n = 261/289) in the week prior to completing the survey. Discussion Mos…
format: application/pdf
format: text/html
creator: Alejandro Trujillo Rivera
creator: Clara Luz Sampieri
creator: Eduardo Antonio Trujillo Rivera
creator: José Roberto Gómez Cruz
subject: Oncology
subject: Public Health
description: doi:10.7717/peerj.17593
publisher: PeerJ Inc.
rights: © 2024 Trujillo Rivera et al.
abstract: Background The recommendations of both the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) for the prevention of cancer are important public health tools. These recommendations for the prevention of specific cancers are related to body weight maintenance; physical activity; foods and drinks that promote weight gain; plant foods; foods of animal origin; alcoholic beverages; preservation, processing, and preparation of food; food supplements; and breastfeeding. Methods This study was a descriptive, cross-sectional, retrospective study. All patients provided written informed consent prior to enrollment in the study. Stratified random sampling was carried out with a convenience sample size of ≥280 participants. The characteristics of the participants were investigated using validated questions. Knowledge about the WCRF/AICR recommendations for the primary prevention of cancer was determined using 14 multiple choice questions validated in this study. Group A included participants who answered that cancer can be prevented and that lifestyle is the main factor related to the onset of cancer; the remaining participants were assigned to Group B. The χ2 test and Mann‒Whitney U test were used to determine differences in the groups. A p-value of ≤0.05 was considered statistically significant. A multiple linear regression analysis with gamma response was performed to assess the knowledge score. Results A total of 289 participants were included; 168 (58%) participants were in group A, and 121 (42%) participants were in group B. Using a 0 to 14 scale, the median (P25, P75) number of correct answers was 11 (10, 12). There was no evidence of a difference between groups in sex, relationship status, literacy skills, years of education, occupation, monthly income per person, and BMI. Most of the participants reported that they did not consume tobacco (n = 259/289) or alcohol (n = 261/289) in the week prior to completing the survey. Discussion Mos…
bibliographic citation: Trujillo Rivera et al. (2024) Cancer prevention recommendations: awareness in a Mexican public hospital. PeerJ 12:e17593 https://doi.org/10.7717/peerj.17593
date submitted: 2023-11-01
date accepted: 2024-05-28
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Trujillo Rivera
  given name: Alejandro
author list: Agent
  family name: Sampieri
  given name: Clara Luz
author list: Agent
  family name: Trujillo Rivera
  given name: Eduardo Antonio
author list: Agent
  family name: Gómez Cruz
  given name: José Roberto
doi: 10.7717/peerj.17593
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: © 2024 Trujillo Rivera et al.
attribution name: Trujillo Rivera et al.

Risk factors of bloodstream infection in erythroderma from atopic dermatitis, psoriasis, and drug reactions: a retrospective observational cohort study
type: item
type: AcademicArticle
description: Background Atopic dermatitis (AD), psoriasis, and drug reactions associated with erythroderma are frequently complicated by infections. However, bloodstream infection (BSI) have received less research attention. Objectives This study aimed to investigate the clinical characteristics and risk factors associated with BSI in patients with erythroderma. Methods A retrospective analysis was conducted on 141 erythroderma cases. Eleven cases were identified as having BSI. Clinical records of both BSI and non-BSI groups were reviewed and compared. Results BSI was diagnosed in 7.80% (11/141) of erythroderma cases, with a breakdown of 7.14% in AD, 2.00% in psoriasis, and 17.14% in drug reactions. Notably, all positive skin cultures (7/7) showed bacterial isolates concordant with blood cultures. Univariate logistic regression analysis revealed several significant associations with BSI, including temperature (≤36.0 or ≥38.5 °C; odds ratio (OR) = 28.06; p < 0.001), chilling (OR = 22.10; p < 0.001), kidney disease (OR = 14.64; p < 0.001), etiology of drug reactions (OR = 4.18; p = 0.03), albumin (ALB) (OR = 0.86; p < 0.01), C-reaction protein (CRP) (OR = 1.01; p = 0.02), interleukin 6 (IL-6) (OR = 1.02; p = 0.02), and procalcitonin (PCT) (OR = 1.07; p = 0.03). Receiver operating characteristic (ROC) curves demonstrated significant associations with ALB (p < 0.001; the area under curve (AUC) = 0.80), PCT (p = 0.009; AUC = 0.74), and CRP (p = 0.02; AUC = 0.71). Conclusions Increased awareness of BSI risk is essential in erythroderma management. Patients with specific risk factors, such as abnormal body temperature (≤36.0 or ≥38.5 °C), chilling sensations, kidney disease, a history of drug reactions, elevated CRP (≥32 mg/L), elevated PCT (≥1.00 ng/ml), and low albumin (≤31.0 g/L), require close monitoring for BSI development.
format: application/pdf
format: text/html
creator: Qian Liufu
creator: Lulu Niu
creator: Shimin He
creator: Xuejiao Zhang
creator: Mukai Chen
subject: Microbiology
subject: Dermatology
subject: Infectious Diseases
description: doi:10.7717/peerj.17701
publisher: PeerJ Inc.
rights: © 2024 Liufu et al.
abstract: Background Atopic dermatitis (AD), psoriasis, and drug reactions associated with erythroderma are frequently complicated by infections. However, bloodstream infection (BSI) have received less research attention. Objectives This study aimed to investigate the clinical characteristics and risk factors associated with BSI in patients with erythroderma. Methods A retrospective analysis was conducted on 141 erythroderma cases. Eleven cases were identified as having BSI. Clinical records of both BSI and non-BSI groups were reviewed and compared. Results BSI was diagnosed in 7.80% (11/141) of erythroderma cases, with a breakdown of 7.14% in AD, 2.00% in psoriasis, and 17.14% in drug reactions. Notably, all positive skin cultures (7/7) showed bacterial isolates concordant with blood cultures. Univariate logistic regression analysis revealed several significant associations with BSI, including temperature (≤36.0 or ≥38.5 °C; odds ratio (OR) = 28.06; p < 0.001), chilling (OR = 22.10; p < 0.001), kidney disease (OR = 14.64; p < 0.001), etiology of drug reactions (OR = 4.18; p = 0.03), albumin (ALB) (OR = 0.86; p < 0.01), C-reaction protein (CRP) (OR = 1.01; p = 0.02), interleukin 6 (IL-6) (OR = 1.02; p = 0.02), and procalcitonin (PCT) (OR = 1.07; p = 0.03). Receiver operating characteristic (ROC) curves demonstrated significant associations with ALB (p < 0.001; the area under curve (AUC) = 0.80), PCT (p = 0.009; AUC = 0.74), and CRP (p = 0.02; AUC = 0.71). Conclusions Increased awareness of BSI risk is essential in erythroderma management. Patients with specific risk factors, such as abnormal body temperature (≤36.0 or ≥38.5 °C), chilling sensations, kidney disease, a history of drug reactions, elevated CRP (≥32 mg/L), elevated PCT (≥1.00 ng/ml), and low albumin (≤31.0 g/L), require close monitoring for BSI development.
bibliographic citation: Liufu et al. (2024) Risk factors of bloodstream infection in erythroderma from atopic dermatitis, psoriasis, and drug reactions: a retrospective observational cohort study. PeerJ 12:e17701 https://doi.org/10.7717/peerj.17701
date submitted: 2024-02-02
date accepted: 2024-06-17
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Liufu
  given name: Qian
author list: Agent
  family name: Niu
  given name: Lulu
author list: Agent
  family name: He
  given name: Shimin
author list: Agent
  family name: Zhang
  given name: Xuejiao
author list: Agent
  family name: Chen
  given name: Mukai
doi: 10.7717/peerj.17701
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: © 2024 Liufu et al.
attribution name: Liufu et al.

https://peerj.com/articles/17706
type: item
type: AcademicArticle
title: The usefulness of peri-trigger female reproductive hormones (delta-FRH) in predicting oocyte maturation in normal ovarian reserve patients who received in vitro fertilization-embryo transfer: a retrospective study
description: Objectives To evaluate the efficacy of peri-trigger female reproductive hormones (FRHs) in the prediction of oocyte maturation in normal ovarian reserve patients during the in vitro fertilization-embryo transfer (IVF-ET) procedure. Materials and Methods A hospital database was used to extract data on IVF-ET cases from January 2020 to September 2021. The levels of female reproductive hormones, including estradiol (E2), luteinizing hormone (LH), progesterone (P), and follicle-stimulating hormone (FSH), were initially evaluated at baseline, the day of the trigger, the day after the trigger, and the day of oocyte retrieval. The relative change in E2, LH, P, FSH between time point 1 (the day of trigger and baseline) and time point 2 (the day after the trigger and day on the trigger) was defined as E2_RoV1/2, LH_RoV1/2, P_RoV1/2, and FSH_RoV1/2, respectively. Univariable and multivariable regression were performed to screen the peri-trigger FRHs for the prediction of oocyte maturation. Results A total of 118 patients were enrolled in our study. Univariable analysis revealed significant associations between E2_RoV1 and the rate of MII oocytes in the GnRH-agonist protocol group (p < 0.05), but not in the GnRH-antagonist protocol group. Conversely, P_RoV2 emerged as a potential predictor for the rate of MII oocytes in both protocol groups (p < 0.05). Multivariable analysis confirmed the significance of P_RoV2 in predicting oocyte maturation rate in both groups (p < 0.05), while the association of E2_RoV1 was not significant in either group. However, within the subgroup of high P_RoV2 in the GnRH-agonist protocol group, association was not observed to be significant. The C-index was 0.83 (95% CI [0.73–0.92]) for the GnRH-agonist protocol group and 0.77 (95% CI [0.63–0.90]) for the GnRH-antagonist protocol group. The ROC curve analysis further supported the satisfactory performance of the models, with area under the curve (AUC) values of 0.79 for the GnRH-agonist protocol grou…
format: application/pdf
format: text/html
creator: Lina He
creator: Qing Xu
creator: Fuming Wan
creator: Li Hao
creator: Yamin Qiu
creator: Xu Ran
creator: Jie Lin
creator: Wei Chen
subject: Gynecology and Obstetrics
subject: Translational Medicine
description: doi:10.7717/peerj.17706
publisher: PeerJ Inc.
rights: © 2024 He et al.
abstract: Objectives To evaluate the efficacy of peri-trigger female reproductive hormones (FRHs) in the prediction of oocyte maturation in normal ovarian reserve patients during the in vitro fertilization-embryo transfer (IVF-ET) procedure. Materials and Methods A hospital database was used to extract data on IVF-ET cases from January 2020 to September 2021. The levels of female reproductive hormones, including estradiol (E2), luteinizing hormone (LH), progesterone (P), and follicle-stimulating hormone (FSH), were initially evaluated at baseline, the day of the trigger, the day after the trigger, and the day of oocyte retrieval. The relative change in E2, LH, P, FSH between time point 1 (the day of trigger and baseline) and time point 2 (the day after the trigger and day on the trigger) was defined as E2_RoV1/2, LH_RoV1/2, P_RoV1/2, and FSH_RoV1/2, respectively. Univariable and multivariable regression were performed to screen the peri-trigger FRHs for the prediction of oocyte maturation. Results A total of 118 patients were enrolled in our study. Univariable analysis revealed significant associations between E2_RoV1 and the rate of MII oocytes in the GnRH-agonist protocol group (p < 0.05), but not in the GnRH-antagonist protocol group. Conversely, P_RoV2 emerged as a potential predictor for the rate of MII oocytes in both protocol groups (p < 0.05). Multivariable analysis confirmed the significance of P_RoV2 in predicting oocyte maturation rate in both groups (p < 0.05), while the association of E2_RoV1 was not significant in either group. However, within the subgroup of high P_RoV2 in the GnRH-agonist protocol group, association was not observed to be significant. The C-index was 0.83 (95% CI [0.73–0.92]) for the GnRH-agonist protocol group and 0.77 (95% CI [0.63–0.90]) for the GnRH-antagonist protocol group. The ROC curve analysis further supported the satisfactory performance of the models, with area under the curve (AUC) values of 0.79 for the GnRH-agonist protocol grou…
bibliographic citation: He et al. (2024) The usefulness of peri-trigger female reproductive hormones (delta-FRH) in predicting oocyte maturation in normal ovarian reserve patients who received in vitro fertilization-embryo transfer: a retrospective study. PeerJ 12:e17706 https://doi.org/10.7717/peerj.17706
date submitted: 2024-02-14
date accepted: 2024-06-18
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by-nc/4.0
author list: Agent
  family name: He
  given name: Lina
author list: Agent
  family name: Xu
  given name: Qing
author list: Agent
  family name: Wan
  given name: Fuming
author list: Agent
  family name: Hao
  given name: Li
author list: Agent
  family name: Qiu
  given name: Yamin
author list: Agent
  family name: Ran
  given name: Xu
author list: Agent
  family name: Lin
  given name: Jie
author list: Agent
  family name: Chen
  given name: Wei
doi: 10.7717/peerj.17706
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: ©2024 He et al.
attribution name: He et al.

Effect of intensity training block on anxiety state and performance in competitive swimmers
type: item
type: AcademicArticle
description: Background An increase in training intensity could create changes in psychological and physiological variables in competitive athletes. For this reason, it is very relevant to know how an intensive training block could influence psychological variables in competitive swimmers. This study examined the effect of an intensive training block (HIT) for 2 weeks on the anxiety state and swimming performance compared to standard aerobic training. Methods Twenty-two male competition swimmers were randomly assigned to two groups: HIT group (n = 11; age = 16.5 ± 0.29 years) and control group following the standard training program (n = 11; age = 16.1 ± 0.33 years). Psychological status variables (cognitive anxiety, somatic anxiety and self-confidence) and swimming performance (100-m front crawl) were measured pre-and post-test. Results A significant effect of time was found for all psychological variables and swimming performance (F ≥ 17.6; p < 0.001; d ≥ 0.97). Furthermore, a significant group × time interaction effect was found in cognitive (F = 14.9; p < 0.001; d = 0.62) and somatic anxiety (F = 5.37; p = 0.031; d = 0.55) were found. Only a significant group effect was found in somatic anxiety (F = 27.1; p < 0.001; d = 1.2). Post hoc comparison revealed that both groups increased their cognitive anxiety and swimming performance, and decreased their self-confidence from pre to post test. However, cognitive anxiety increase significantly more in the HIT group compared to the control group. Furthermore, only the HIT training group significantly increased somatic anxiety over time, while somatic anxiety did not change significantly over time in the control group. Conclusion Our findings indicated that a sudden increase in training intensity increased state anxiety more than standard training, but both conditions similarly enhanced swimming performance. Although the current level of psychological state is not affecting swimming performance negatively over this period, it should …
format: application/pdf
format: text/html
creator: Hajer Aouani
creator: Sofiene Amara
creator: Faten Sahli
creator: Tiago M. Barbosa
creator: Nizar Souissi
creator: Roland van den Tillaar
subject: Psychiatry and Psychology
subject: Public Health
subject: Rehabilitation
subject: Sports Medicine
description: doi:10.7717/peerj.17708
publisher: PeerJ Inc.
rights: © 2024 Aouani et al.
abstract: Background An increase in training intensity could create changes in psychological and physiological variables in competitive athletes. For this reason, it is very relevant to know how an intensive training block could influence psychological variables in competitive swimmers. This study examined the effect of an intensive training block (HIT) for 2 weeks on the anxiety state and swimming performance compared to standard aerobic training. Methods Twenty-two male competition swimmers were randomly assigned to two groups: HIT group (n = 11; age = 16.5 ± 0.29 years) and control group following the standard training program (n = 11; age = 16.1 ± 0.33 years). Psychological status variables (cognitive anxiety, somatic anxiety and self-confidence) and swimming performance (100-m front crawl) were measured pre-and post-test. Results A significant effect of time was found for all psychological variables and swimming performance (F ≥ 17.6; p < 0.001; d ≥ 0.97). Furthermore, a significant group × time interaction effect was found in cognitive (F = 14.9; p < 0.001; d = 0.62) and somatic anxiety (F = 5.37; p = 0.031; d = 0.55) were found. Only a significant group effect was found in somatic anxiety (F = 27.1; p < 0.001; d = 1.2). Post hoc comparison revealed that both groups increased their cognitive anxiety and swimming performance, and decreased their self-confidence from pre to post test. However, cognitive anxiety increase significantly more in the HIT group compared to the control group. Furthermore, only the HIT training group significantly increased somatic anxiety over time, while somatic anxiety did not change significantly over time in the control group. Conclusion Our findings indicated that a sudden increase in training intensity increased state anxiety more than standard training, but both conditions similarly enhanced swimming performance. Although the current level of psychological state is not affecting swimming performance negatively over this period, it should …
bibliographic citation: Aouani et al. (2024) Effect of intensity training block on anxiety state and performance in competitive swimmers. PeerJ 12:e17708 https://doi.org/10.7717/peerj.17708
date submitted: 2023-04-21
date accepted: 2024-06-18
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Aouani
  given name: Hajer
author list: Agent
  family name: Amara
  given name: Sofiene
author list: Agent
  family name: Sahli
  given name: Faten
author list: Agent
  family name: Barbosa
  given name: Tiago M.
author list: Agent
  family name: Souissi
  given name: Nizar
author list: Agent
  family name: Tillaar
  given name: Roland van den
doi: 10.7717/peerj.17708
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: © 2024 Aouani et al.
attribution name: Aouani et al.

Do the effects last? A comparison between internal and external focus of attention instructions on golf putting accuracy over multiple days
type: item
type: AcademicArticle
description: Background The role of attentional focus is a well-explored topic in exercise sciences. Studies generally indicate that external focus (EF) enhances motor performance and learning compared with internal focus (IF). However, most studies only included one or two experimental days which limits participants’ exposure to the focus conditions. This raises the question of whether the superiority of EF varies over time. Methods Accordingly, in this pre-registered within-subject study, we examined the effects of focus instructions on golf-putting performance over four days, with 48–72 h between them. On each day, participants performed 15 putts under three instructional conditions: (1) EF, (2) IF, and (3) control, in a randomized and counterbalanced order. Results We observed trivial differences in performance between conditions but considerable improvements from day 1 to day 4. When using an exploratory analysis, we found that participants performed better under EF and control conditions compared with the IF condition on day 1, but not on subsequent days. Conclusions Since IF instructions are more commonly used in practice, we speculate that the two other focus conditions were experienced as more novel, potentially accounting for their superiority on Day 1. Nevertheless, our results question the significance of employing EF to enhance performance.
format: application/pdf
format: text/html
creator: Miri Nevo
creator: Israel Halperin
creator: Gal Ziv
subject: Kinesiology
subject: Psychiatry and Psychology
description: doi:10.7717/peerj.17718
publisher: PeerJ Inc.
rights: © 2024 Nevo et al.
abstract: Background The role of attentional focus is a well-explored topic in exercise sciences. Studies generally indicate that external focus (EF) enhances motor performance and learning compared with internal focus (IF). However, most studies only included one or two experimental days which limits participants’ exposure to the focus conditions. This raises the question of whether the superiority of EF varies over time. Methods Accordingly, in this pre-registered within-subject study, we examined the effects of focus instructions on golf-putting performance over four days, with 48–72 h between them. On each day, participants performed 15 putts under three instructional conditions: (1) EF, (2) IF, and (3) control, in a randomized and counterbalanced order. Results We observed trivial differences in performance between conditions but considerable improvements from day 1 to day 4. When using an exploratory analysis, we found that participants performed better under EF and control conditions compared with the IF condition on day 1, but not on subsequent days. Conclusions Since IF instructions are more commonly used in practice, we speculate that the two other focus conditions were experienced as more novel, potentially accounting for their superiority on Day 1. Nevertheless, our results question the significance of employing EF to enhance performance.
bibliographic citation: Nevo et al. (2024) Do the effects last? A comparison between internal and external focus of attention instructions on golf putting accuracy over multiple days. PeerJ 12:e17718 https://doi.org/10.7717/peerj.17718
date submitted: 2024-04-16
date accepted: 2024-06-18
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Nevo
  given name: Miri
author list: Agent
  family name: Halperin
  given name: Israel
author list: Agent
  family name: Ziv
  given name: Gal
doi: 10.7717/peerj.17718
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: © 2024 Nevo et al.
attribution name: Nevo et al.

Hypertension in frail older adults: current perspectives
type: item
type: AcademicArticle
description: Hypertension is one of the most common chronic diseases in older people, and the prevalence is on the rise as the global population ages. Hypertension is closely associated with many adverse health outcomes, including cardiovascular disease, chronic kidney disease and mortality, which poses a substantial threat to global public health. Reasonable blood pressure (BP) management is very important for reducing the occurrence of adverse events. Frailty is an age-related geriatric syndrome, characterized by decreased physiological reserves of multiple organs and systems and increased sensitivity to stressors, which increases the risk of falls, hospitalization, fractures, and mortality in older people. With the aging of the global population and the important impact of frailty on clinical practice, frailty has attracted increasing attention in recent years. In older people, frailty and hypertension often coexist. Frailty has a negative impact on BP management and the prognosis of older hypertensive patients, while hypertension may increase the risk of frailty in older people. However, the causal relationship between frailty and hypertension remains unclear, and there is a paucity of research regarding the efficacious management of hypertension in frail elderly patients. The management of hypertension in frail elderly patients still faces significant challenges. The benefits of treatment, the optimal BP target, and the choice of antihypertensive drugs for older hypertensive patients with frailty remain subjects of ongoing debate. This review provides a brief overview of hypertension in frail older adults, especially for the management of BP in this population, which may help in offering valuable ideas for future research in this field.
format: application/pdf
format: text/html
creator: Liying Li
creator: Linjia Duan
creator: Ying Xu
creator: Haiyan Ruan
creator: Muxin Zhang
creator: Yi Zheng
creator: Sen He
subject: Cardiology
subject: Geriatrics
subject: Internal Medicine
description: doi:10.7717/peerj.17760
publisher: PeerJ Inc.
rights: © 2024 Li et al.
abstract: Hypertension is one of the most common chronic diseases in older people, and the prevalence is on the rise as the global population ages. Hypertension is closely associated with many adverse health outcomes, including cardiovascular disease, chronic kidney disease and mortality, which poses a substantial threat to global public health. Reasonable blood pressure (BP) management is very important for reducing the occurrence of adverse events. Frailty is an age-related geriatric syndrome, characterized by decreased physiological reserves of multiple organs and systems and increased sensitivity to stressors, which increases the risk of falls, hospitalization, fractures, and mortality in older people. With the aging of the global population and the important impact of frailty on clinical practice, frailty has attracted increasing attention in recent years. In older people, frailty and hypertension often coexist. Frailty has a negative impact on BP management and the prognosis of older hypertensive patients, while hypertension may increase the risk of frailty in older people. However, the causal relationship between frailty and hypertension remains unclear, and there is a paucity of research regarding the efficacious management of hypertension in frail elderly patients. The management of hypertension in frail elderly patients still faces significant challenges. The benefits of treatment, the optimal BP target, and the choice of antihypertensive drugs for older hypertensive patients with frailty remain subjects of ongoing debate. This review provides a brief overview of hypertension in frail older adults, especially for the management of BP in this population, which may help in offering valuable ideas for future research in this field.
bibliographic citation: Li et al. (2024) Hypertension in frail older adults: current perspectives. PeerJ 12:e17760 https://doi.org/10.7717/peerj.17760
date submitted: 2023-09-13
date accepted: 2024-06-26
issued: 2024-07-11
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Li
  given name: Liying
author list: Agent
  family name: Duan
  given name: Linjia
author list: Agent
  family name: Xu
  given name: Ying
author list: Agent
  family name: Ruan
  given name: Haiyan
author list: Agent
  family name: Zhang
  given name: Muxin
author list: Agent
  family name: Zheng
  given name: Yi
author list: Agent
  family name: He
  given name: Sen
doi: 10.7717/peerj.17760
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-11
copyright: © 2024 Li et al.
attribution name: Li et al.

Anthropogenic fertilization influences a shift in barley rhizosphere microbial communities
type: item
type: AcademicArticle
description: Background Anthropogenic mediations contribute a significant role in stimulating positive reactions in soil–plant interactions; however, methodical reports on how anthropogenic activities impact soil microorganism-induced properties and soil health are still inadequate. In this study, we evaluated the influence of anthropogenic fertilization of farmland soil on barley rhizosphere microbial community structure and diversity, and the significant impacts on agro-ecosystem productivity. This will help validate the premise that soil amendment with prolonged synthetic fertilizers can lead to a significant reduction in bacterial abundance and diversity, while soils amended with organic fertilizers elicit the succession of the native soil microbial community and favor the growth of copiotrophic bacteria. Methods The total metagenomic DNA was extracted from soils obtained from the barley rhizosphere under chemical fertilization (CB), organic fertilization (OB), and bulk soil (NB). Subsequently, these samples were sequenced using an amplicon-based sequencing approach, and the raw sequence dataset was examined using a metagenomic rast server (MG-RAST). Results Our findings showed that all environments (CB, OB, and NB) shared numerous soil bacterial phyla but with different compositions. However, Bacteroidetes, Proteobacteria, and Actinobacteria predominated in the barley rhizosphere under chemical fertilization, organic fertilization, and bulk soils, respectively. Alpha and beta diversity analysis showed that the diversity of bacteria under organic barley rhizosphere was significantly higher and more evenly distributed than bacteria under chemical fertilization and bulk soil. Conclusion Understanding the impact of conventional and organic fertilizers on the structure, composition, and diversity of the rhizosphere microbiome will assist in soil engineering to enhance microbial diversity in the agroecosystem.
format: application/pdf
format: text/html
creator: Ben Jesuorsemwen Enagbonma
creator: Ayomide Emmanuel Fadiji
creator: Olubukola Oluranti Babalola
subject: Agricultural Science
subject: Biodiversity
subject: Bioinformatics
subject: Microbiology
subject: Soil Science
description: doi:10.7717/peerj.17303
publisher: PeerJ Inc.
rights: © 2024 Enagbonma et al.
abstract: Background Anthropogenic mediations contribute a significant role in stimulating positive reactions in soil–plant interactions; however, methodical reports on how anthropogenic activities impact soil microorganism-induced properties and soil health are still inadequate. In this study, we evaluated the influence of anthropogenic fertilization of farmland soil on barley rhizosphere microbial community structure and diversity, and the significant impacts on agro-ecosystem productivity. This will help validate the premise that soil amendment with prolonged synthetic fertilizers can lead to a significant reduction in bacterial abundance and diversity, while soils amended with organic fertilizers elicit the succession of the native soil microbial community and favor the growth of copiotrophic bacteria. Methods The total metagenomic DNA was extracted from soils obtained from the barley rhizosphere under chemical fertilization (CB), organic fertilization (OB), and bulk soil (NB). Subsequently, these samples were sequenced using an amplicon-based sequencing approach, and the raw sequence dataset was examined using a metagenomic rast server (MG-RAST). Results Our findings showed that all environments (CB, OB, and NB) shared numerous soil bacterial phyla but with different compositions. However, Bacteroidetes, Proteobacteria, and Actinobacteria predominated in the barley rhizosphere under chemical fertilization, organic fertilization, and bulk soils, respectively. Alpha and beta diversity analysis showed that the diversity of bacteria under organic barley rhizosphere was significantly higher and more evenly distributed than bacteria under chemical fertilization and bulk soil. Conclusion Understanding the impact of conventional and organic fertilizers on the structure, composition, and diversity of the rhizosphere microbiome will assist in soil engineering to enhance microbial diversity in the agroecosystem.
bibliographic citation: Enagbonma et al. (2024) Anthropogenic fertilization influences a shift in barley rhizosphere microbial communities. PeerJ 12:e17303 https://doi.org/10.7717/peerj.17303
date submitted: 2023-12-11
date accepted: 2024-04-04
issued: 2024-07-10
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Enagbonma
  given name: Ben Jesuorsemwen
author list: Agent
  family name: Fadiji
  given name: Ayomide Emmanuel
author list: Agent
  family name: Babalola
  given name: Olubukola Oluranti
doi: 10.7717/peerj.17303
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-10
copyright: © 2024 Enagbonma et al.
attribution name: Enagbonma et al.

Estimation of environment stability for fruit yield and capsaicin content by using two models in Capsicum chinense Jacq. (Ghost Pepper) with multi-year evaluation
type: item
type: AcademicArticle
description: Background Capsicum chinense Jacq. (Ghost Pepper) is well-known for its high pungency and pleasant aroma. The recent years witnessed a significant decline in popularity of this important crop due to the use of inferior planting material and lack of elite lines. To maintain constant performance across a variety of settings, it is crucial to choose stable lines with high yield and capsaicin content, as these are the most promising traits of Ghost Pepper. Method In this study, 120 high-capsaicin genotypes were subjected to a 3-year (kharif 2017, 2018 and 2019) stability investigation utilizing two well-known stability methods: Eberhart-Russell (ER) and additive main effects and multiple interaction (AMMI). Three replications were used following Randomized Complete Block Design for 11 traits. The experiment soil was sandy loam with pH 4.9. Minimum and maximum temperature of 18.5 °C, 17.5 °C, 17.4 °C and 32.2 °C, 31.3 °C, 32.7 °C and rainfall of 1,781, 2,099, 1,972 mm respectively was recorded for the study period. Result The genotype-environment linear interaction (G×E Lin.) was highly significant for days to 50% flowering, capsaicin content, fruit length and girth, fruit yield per plant and number of fruits per plant at p < 0.005. G×E interaction for fruit yield and capsaicin content in AMMI-analysis of variance reported 67.07% and 71.51% contribution by IPCA-1 (interactive principal component axis) and 32.76% and 28.49% by IPCA-2, respectively. Eight genotypes were identified to be stable with high yield and capsaicin content. The identified stable lines can be opted for cultivation to reduce the impact of crop failure when grown in different macro-environments. Moreover, the pharmaceutical and spice sectors will also be benefitted from the lines with high capsaicin content. Further research assessing the lines’ performance across various regions of India can provide a solid foundation for the crop’s evaluation at national level.
format: application/pdf
format: text/html
creator: Joyashree Baruah
creator: Twahira Begum
creator: Mohan Lal
subject: Agricultural Science
subject: Plant Science
description: doi:10.7717/peerj.17511
publisher: PeerJ Inc.
rights: © 2024 Baruah et al.
abstract: Background Capsicum chinense Jacq. (Ghost Pepper) is well-known for its high pungency and pleasant aroma. The recent years witnessed a significant decline in popularity of this important crop due to the use of inferior planting material and lack of elite lines. To maintain constant performance across a variety of settings, it is crucial to choose stable lines with high yield and capsaicin content, as these are the most promising traits of Ghost Pepper. Method In this study, 120 high-capsaicin genotypes were subjected to a 3-year (kharif 2017, 2018 and 2019) stability investigation utilizing two well-known stability methods: Eberhart-Russell (ER) and additive main effects and multiple interaction (AMMI). Three replications were used following Randomized Complete Block Design for 11 traits. The experiment soil was sandy loam with pH 4.9. Minimum and maximum temperature of 18.5 °C, 17.5 °C, 17.4 °C and 32.2 °C, 31.3 °C, 32.7 °C and rainfall of 1,781, 2,099, 1,972 mm respectively was recorded for the study period. Result The genotype-environment linear interaction (G×E Lin.) was highly significant for days to 50% flowering, capsaicin content, fruit length and girth, fruit yield per plant and number of fruits per plant at p < 0.005. G×E interaction for fruit yield and capsaicin content in AMMI-analysis of variance reported 67.07% and 71.51% contribution by IPCA-1 (interactive principal component axis) and 32.76% and 28.49% by IPCA-2, respectively. Eight genotypes were identified to be stable with high yield and capsaicin content. The identified stable lines can be opted for cultivation to reduce the impact of crop failure when grown in different macro-environments. Moreover, the pharmaceutical and spice sectors will also be benefitted from the lines with high capsaicin content. Further research assessing the lines’ performance across various regions of India can provide a solid foundation for the crop’s evaluation at national level.
bibliographic citation: Baruah et al. (2024) Estimation of environment stability for fruit yield and capsaicin content by using two models in Capsicum chinense Jacq. (Ghost Pepper) with multi-year evaluation. PeerJ 12:e17511 https://doi.org/10.7717/peerj.17511
date submitted: 2024-02-13
date accepted: 2024-05-13
issued: 2024-07-10
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Baruah
  given name: Joyashree
author list: Agent
  family name: Begum
  given name: Twahira
author list: Agent
  family name: Lal
  given name: Mohan
doi: 10.7717/peerj.17511
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-10
copyright: © 2024 Baruah et al.
attribution name: Baruah et al.

Identification and validation of calcium extrusion-related genes prognostic signature in colon adenocarcinoma
type: item
type: AcademicArticle
description: Background Disruptions in calcium homeostasis are associated with a wide range of diseases, and play a pivotal role in the development of cancer. However, the construction of prognostic models using calcium extrusion-related genes in colon adenocarcinoma (COAD) has not been well studied. We aimed to identify whether calcium extrusion-related genes serve as a potential prognostic biomarker in the COAD progression. Methods We constructed a prognostic model based on the expression of calcium extrusion-related genes (SLC8A1, SLC8A2, SLC8A3, SLC8B1, SLC24A2, SLC24A3 and SLC24A4) in COAD. Subsequently, we evaluated the associations between the risk score calculated by calcium extrusion-related genes and mutation signature, immune cell infiltration, and immune checkpoint molecules. Then we calculated the immune score, stromal score, tumor purity and estimate score using the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm. The response to immunotherapy was assessed using tumor immune dysfunction and exclusion (TIDE). Finally, colorectal cancer cells migration, growth and colony formation assays were performed in RKO cells with the overexpression or knockdown SLC8A3, SLC24A2, SLC24A3, or SLC24A4. Results We found that patients with high risk score of calcium extrusion-related genes tend to have a poorer prognosis than those in the low-risk group. Additionally, patients in high-risk group had higher rates of KRAS mutations and lower MUC16 mutations, implying a strong correlation between KRAS and MUC16 mutations and calcium homeostasis in COAD. Moreover, the high-risk group showed a higher infiltration of regulatory T cells (Tregs) in the tumor microenvironment. Finally, our study identified two previously unreported model genes (SLC8A3 and SLC24A4) that contribute to the growth and migration of colorectal cancer RKO cells. Conclusions Altogether, we developed a prognostic risk model for predicting the prognosis of C…
format: application/pdf
format: text/html
creator: Mingpeng Jin
creator: Chun Yin
creator: Jie Yang
creator: Xiaoning Yang
creator: Jing Wang
creator: Jianjun Zhu
creator: Jian Yuan
subject: Cell Biology
subject: Molecular Biology
subject: Oncology
description: doi:10.7717/peerj.17582
publisher: PeerJ Inc.
rights: © 2024 Jin et al.
abstract: Background Disruptions in calcium homeostasis are associated with a wide range of diseases, and play a pivotal role in the development of cancer. However, the construction of prognostic models using calcium extrusion-related genes in colon adenocarcinoma (COAD) has not been well studied. We aimed to identify whether calcium extrusion-related genes serve as a potential prognostic biomarker in the COAD progression. Methods We constructed a prognostic model based on the expression of calcium extrusion-related genes (SLC8A1, SLC8A2, SLC8A3, SLC8B1, SLC24A2, SLC24A3 and SLC24A4) in COAD. Subsequently, we evaluated the associations between the risk score calculated by calcium extrusion-related genes and mutation signature, immune cell infiltration, and immune checkpoint molecules. Then we calculated the immune score, stromal score, tumor purity and estimate score using the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm. The response to immunotherapy was assessed using tumor immune dysfunction and exclusion (TIDE). Finally, colorectal cancer cells migration, growth and colony formation assays were performed in RKO cells with the overexpression or knockdown SLC8A3, SLC24A2, SLC24A3, or SLC24A4. Results We found that patients with high risk score of calcium extrusion-related genes tend to have a poorer prognosis than those in the low-risk group. Additionally, patients in high-risk group had higher rates of KRAS mutations and lower MUC16 mutations, implying a strong correlation between KRAS and MUC16 mutations and calcium homeostasis in COAD. Moreover, the high-risk group showed a higher infiltration of regulatory T cells (Tregs) in the tumor microenvironment. Finally, our study identified two previously unreported model genes (SLC8A3 and SLC24A4) that contribute to the growth and migration of colorectal cancer RKO cells. Conclusions Altogether, we developed a prognostic risk model for predicting the prognosis of C…
bibliographic citation: Jin et al. (2024) Identification and validation of calcium extrusion-related genes prognostic signature in colon adenocarcinoma. PeerJ 12:e17582 https://doi.org/10.7717/peerj.17582
date submitted: 2023-11-24
date accepted: 2024-05-25
issued: 2024-07-10
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Jin
  given name: Mingpeng
author list: Agent
  family name: Yin
  given name: Chun
author list: Agent
  family name: Yang
  given name: Jie
author list: Agent
  family name: Yang
  given name: Xiaoning
author list: Agent
  family name: Wang
  given name: Jing
author list: Agent
  family name: Zhu
  given name: Jianjun
author list: Agent
  family name: Yuan
  given name: Jian
doi: 10.7717/peerj.17582
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-10
copyright: ©2024 Jin et al.
attribution name: Jin et al.

Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma
type: item
type: AcademicArticle
description: Background Human olfactory receptors (ORs) account for approximately 60% of all human G protein-coupled receptors. The functions of ORs extend beyond olfactory perception and have garnered significant attention in tumor biology. However, a comprehensive pan-cancer analysis of ORs in human cancers is lacking. Methods Using data from public databases, such as HPA, TCGA, GEO, GTEx, TIMER2, TISDB, UALCAN, GEPIA2, and GSCA, this study investigated the role of olfactory receptor family 7 subfamily A member 5 (OR7A5) in various cancers. Functional analysis of OR7A5 in LGG and GBM was performed using the CGGA database. Molecular and cellular experiments were performed to validate the expression and biological function of OR7A5 in gliomas. Results The results revealed heightened OR7A5 expression in certain tumors, correlating with the expression levels of immune checkpoints and immune infiltration. In patients with gliomas, the expression levels of OR7A5 were closely associated with adverse prognosis, 1p/19p co-deletion status, and wild-type IDH status. Finally, in vitro experiments confirmed the inhibitory effect of OR7A5 knockdown on the proliferative capacity of glioma cells and on the expression levels of proteins related to lipid metabolism. Conclusion This study establishes OR7A5 as a novel biomarker, potentially offering a novel therapeutic target for gliomas.
format: application/pdf
format: text/html
creator: Yanqiu Bao
creator: Ziqi Tang
creator: Renli Chen
creator: Xuebin Yu
creator: Xuchen Qi
subject: Biochemistry
subject: Bioinformatics
subject: Neurology
subject: Oncology
description: doi:10.7717/peerj.17631
publisher: PeerJ Inc.
rights: © 2024 Bao et al.
abstract: Background Human olfactory receptors (ORs) account for approximately 60% of all human G protein-coupled receptors. The functions of ORs extend beyond olfactory perception and have garnered significant attention in tumor biology. However, a comprehensive pan-cancer analysis of ORs in human cancers is lacking. Methods Using data from public databases, such as HPA, TCGA, GEO, GTEx, TIMER2, TISDB, UALCAN, GEPIA2, and GSCA, this study investigated the role of olfactory receptor family 7 subfamily A member 5 (OR7A5) in various cancers. Functional analysis of OR7A5 in LGG and GBM was performed using the CGGA database. Molecular and cellular experiments were performed to validate the expression and biological function of OR7A5 in gliomas. Results The results revealed heightened OR7A5 expression in certain tumors, correlating with the expression levels of immune checkpoints and immune infiltration. In patients with gliomas, the expression levels of OR7A5 were closely associated with adverse prognosis, 1p/19p co-deletion status, and wild-type IDH status. Finally, in vitro experiments confirmed the inhibitory effect of OR7A5 knockdown on the proliferative capacity of glioma cells and on the expression levels of proteins related to lipid metabolism. Conclusion This study establishes OR7A5 as a novel biomarker, potentially offering a novel therapeutic target for gliomas.
bibliographic citation: Bao et al. (2024) Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma. PeerJ 12:e17631 https://doi.org/10.7717/peerj.17631
date submitted: 2024-02-04
date accepted: 2024-06-04
issued: 2024-07-10
is part of: PeerJ
license: https://creativecommons.org/licenses/by-nc/4.0
author list: Agent
  family name: Bao
  given name: Yanqiu
author list: Agent
  family name: Tang
  given name: Ziqi
author list: Agent
  family name: Chen
  given name: Renli
author list: Agent
  family name: Yu
  given name: Xuebin
author list: Agent
  family name: Qi
  given name: Xuchen
doi: 10.7717/peerj.17631
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-07-10
copyright: ©2024 Bao et al.
attribution name: Bao et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359