PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: Changes in the force-time curve during a repeat power ability assessment using loaded countermovement jumps
items: Acute psycho-physiological responses to submaximal constant-load cycling under intermittent hypoxia-hyperoxia vs. hypoxia-normoxia in young males
items: A method for evaluating sediment-induced macroinvertebrate community composition changes in Idaho streams
items: https://peerj.com/articles/18126
items: Impact of foam rolling with and without vibration on muscle oxidative metabolism and microvascular reactivity
items: Association between triglyceride glycemic index and ejection fraction preserved heart failure in hypertensive patients
items: The non-HDL-C to APOB ratio as a predictor of inaccurate LDL-C measurement in patients with chronic intrahepatic cholestasis and jaundice: a retrospective study
items: Reliability and reproducibility of an Italian questionnaire on “Knowledge of high social impact Eye Diseases” (KED-IT)
items: Nanotechnology in action: silver nanoparticles for improved eco-friendly remediation
items: PotatoG-DKB: a potato gene-disease knowledge base mined from biological literature

Changes in the force-time curve during a repeat power ability assessment using loaded countermovement jumps
type: item
type: AcademicArticle
description: Background Repeat power ability (RPA) assessments traditionally use discrete variables, such as peak power output, to quantify the change in performance across a series of jumps. Rather than using a discrete variable, the analysis of the entire force-time curve may provide additional insight into RPA performance. The aims of this study were to (1) analyse changes in the force-time curve recorded during an RPA assessment using statistical parametric mapping (SPM) and (2) compare the differences in the force-time curve between participants with low and high RPA scores, as quantified by traditional analysis. Materials and Methods Eleven well-trained field hockey players performed an RPA assessment consisting of 20 loaded countermovement jumps with a 30% one repetition maximum half squat load (LCMJ20). Mean force-time series data was normalized to 100% of the movement duration and analysed using SPM. Peak power output for each jump was also derived from the force-time data and a percent decrement score calculated for jumps 2 to 19 (RPA%dec). An SPM one-way ANOVA with significance accepted at α = 0.05, was used to identify the change in the force-time curve over three distinct series of jumps across the LCMJ20 (series 1 = jumps 2–5, series 2 = jumps 9–12 and series 3 = jumps 16–19). A secondary analysis, using an independent T-test with significance accepted at p < 0.001, was also used to identify differences in the force-time curve between participants with low and high RPA%dec. Results Propulsive forces were significantly lower (p < 0.001) between 74–98% of the movement compared to 0–73% for changes recorded during the LCMJ20. Post hoc analysis identified the greatest differences to occur between jump series 1 and jump series 2 (p < 0.001) at 70–98% of the movement and between jump series 1 and jump series 3 (p < 0.001) at 86–99% of the movement. No significant differences were found between jump series 2 and jump series 3. Significant differences (p < 0.001) in both t…
format: application/pdf
format: text/html
creator: Alex O. Natera
creator: Steven Hughes
creator: Dale W. Chapman
creator: Neil D. Chapman
creator: Justin W.L. Keogh
subject: Anatomy and Physiology
subject: Kinesiology
subject: Biomechanics
subject: Sports Medicine
description: doi:10.7717/peerj.17971
publisher: PeerJ Inc.
rights: © 2024 Natera et al.
abstract: Background Repeat power ability (RPA) assessments traditionally use discrete variables, such as peak power output, to quantify the change in performance across a series of jumps. Rather than using a discrete variable, the analysis of the entire force-time curve may provide additional insight into RPA performance. The aims of this study were to (1) analyse changes in the force-time curve recorded during an RPA assessment using statistical parametric mapping (SPM) and (2) compare the differences in the force-time curve between participants with low and high RPA scores, as quantified by traditional analysis. Materials and Methods Eleven well-trained field hockey players performed an RPA assessment consisting of 20 loaded countermovement jumps with a 30% one repetition maximum half squat load (LCMJ20). Mean force-time series data was normalized to 100% of the movement duration and analysed using SPM. Peak power output for each jump was also derived from the force-time data and a percent decrement score calculated for jumps 2 to 19 (RPA%dec). An SPM one-way ANOVA with significance accepted at α = 0.05, was used to identify the change in the force-time curve over three distinct series of jumps across the LCMJ20 (series 1 = jumps 2–5, series 2 = jumps 9–12 and series 3 = jumps 16–19). A secondary analysis, using an independent T-test with significance accepted at p < 0.001, was also used to identify differences in the force-time curve between participants with low and high RPA%dec. Results Propulsive forces were significantly lower (p < 0.001) between 74–98% of the movement compared to 0–73% for changes recorded during the LCMJ20. Post hoc analysis identified the greatest differences to occur between jump series 1 and jump series 2 (p < 0.001) at 70–98% of the movement and between jump series 1 and jump series 3 (p < 0.001) at 86–99% of the movement. No significant differences were found between jump series 2 and jump series 3. Significant differences (p < 0.001) in both t…
bibliographic citation: Natera et al. (2024) Changes in the force-time curve during a repeat power ability assessment using loaded countermovement jumps. PeerJ 12:e17971 https://doi.org/10.7717/peerj.17971
date submitted: 2024-02-09
date accepted: 2024-08-05
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Natera
  given name: Alex O.
author list: Agent
  family name: Hughes
  given name: Steven
author list: Agent
  family name: Chapman
  given name: Dale W.
author list: Agent
  family name: Chapman
  given name: Neil D.
author list: Agent
  family name: Keogh
  given name: Justin W.L.
doi: 10.7717/peerj.17971
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: ©2024 Natera et al.
attribution name: Natera et al.

Acute psycho-physiological responses to submaximal constant-load cycling under intermittent hypoxia-hyperoxia vs. hypoxia-normoxia in young males
type: item
type: AcademicArticle
description: Background Hypoxia and hyperoxia can affect the acute psycho-physiological response to exercise. Recording various perceptual responses to exercise is of particular importance for investigating behavioral changes to physical activity, given that the perception of exercise-induced pain, discomfort or unpleasure, and a low level of exercise enjoyment are commonly associated with a low adherence to physical activity. Therefore, this study aimed to compare the acute perceptual and physiological responses to aerobic exercise under intermittent hypoxia-hyperoxia (IHHT), hypoxia-normoxia (IHT), and sustained normoxia (NOR) in young, recreational active, healthy males. Methods Using a randomized, single-blinded, crossover design, 15 males (age: 24.5 ± 4.2 yrs) performed 40 min of submaximal constant-load cycling (at 60% peak oxygen uptake, 80 rpm) under IHHT (5 × 4 min hypoxia and hyperoxia), IHT (5 × 4 min hypoxia and normoxia), and NOR. Inspiratory fraction of oxygen during hypoxia and hyperoxia was set to 14% and 30%, respectively. Heart rate (HR), total hemoglobin (tHb) and muscle oxygen saturation (SmO2) of the right vastus lateralis muscle were continuously recorded during cycling. Participants’ peripheral oxygen saturation (SpO2) and perceptual responses (i.e., perceived motor fatigue, effort perception, perceived physical strain, affective valence, arousal, motivation to exercise, and conflict to continue exercise) were surveyed prior, during (every 4 min), and after cycling. Prior to and after exercise, peripheral blood lactate concentration (BLC) was determined. Exercise enjoyment was ascertained after cycling. For statistical analysis, repeated measures analyses of variance were conducted. Results No differences in the acute perceptual responses were found between conditions (p ≥ 0.059, ηp2 ≤ 0.18), while the physiological responses differed. Accordingly, SpO2 was higher during the hyperoxic periods during the IHHT compared to the normoxic periods during the IHT …
format: application/pdf
format: text/html
creator: Tom Behrendt
creator: Robert Bielitzki
creator: Martin Behrens
creator: Lina-Marie Jahns
creator: Malte Boersma
creator: Lutz Schega
subject: Anatomy and Physiology
subject: Psychiatry and Psychology
subject: Metabolic Sciences
subject: Sports Medicine
description: doi:10.7717/peerj.18027
publisher: PeerJ Inc.
rights: © 2024 Behrendt et al.
abstract: Background Hypoxia and hyperoxia can affect the acute psycho-physiological response to exercise. Recording various perceptual responses to exercise is of particular importance for investigating behavioral changes to physical activity, given that the perception of exercise-induced pain, discomfort or unpleasure, and a low level of exercise enjoyment are commonly associated with a low adherence to physical activity. Therefore, this study aimed to compare the acute perceptual and physiological responses to aerobic exercise under intermittent hypoxia-hyperoxia (IHHT), hypoxia-normoxia (IHT), and sustained normoxia (NOR) in young, recreational active, healthy males. Methods Using a randomized, single-blinded, crossover design, 15 males (age: 24.5 ± 4.2 yrs) performed 40 min of submaximal constant-load cycling (at 60% peak oxygen uptake, 80 rpm) under IHHT (5 × 4 min hypoxia and hyperoxia), IHT (5 × 4 min hypoxia and normoxia), and NOR. Inspiratory fraction of oxygen during hypoxia and hyperoxia was set to 14% and 30%, respectively. Heart rate (HR), total hemoglobin (tHb) and muscle oxygen saturation (SmO2) of the right vastus lateralis muscle were continuously recorded during cycling. Participants’ peripheral oxygen saturation (SpO2) and perceptual responses (i.e., perceived motor fatigue, effort perception, perceived physical strain, affective valence, arousal, motivation to exercise, and conflict to continue exercise) were surveyed prior, during (every 4 min), and after cycling. Prior to and after exercise, peripheral blood lactate concentration (BLC) was determined. Exercise enjoyment was ascertained after cycling. For statistical analysis, repeated measures analyses of variance were conducted. Results No differences in the acute perceptual responses were found between conditions (p ≥ 0.059, ηp2 ≤ 0.18), while the physiological responses differed. Accordingly, SpO2 was higher during the hyperoxic periods during the IHHT compared to the normoxic periods during the IHT …
bibliographic citation: Behrendt et al. (2024) Acute psycho-physiological responses to submaximal constant-load cycling under intermittent hypoxia-hyperoxia vs. hypoxia-normoxia in young males. PeerJ 12:e18027 https://doi.org/10.7717/peerj.18027
date submitted: 2024-03-22
date accepted: 2024-08-12
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Behrendt
  given name: Tom
author list: Agent
  family name: Bielitzki
  given name: Robert
author list: Agent
  family name: Behrens
  given name: Martin
author list: Agent
  family name: Jahns
  given name: Lina-Marie
author list: Agent
  family name: Boersma
  given name: Malte
author list: Agent
  family name: Schega
  given name: Lutz
doi: 10.7717/peerj.18027
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: © 2024 Behrendt et al.
attribution name: Behrendt et al.

A method for evaluating sediment-induced macroinvertebrate community composition changes in Idaho streams
type: item
type: AcademicArticle
description: Human activities can increase sediment delivery to streams, changing the composition, distribution, and abundance of stream aquatic life. Few U.S. states have numeric water quality standards for streambed sediment under the Clean Water Act, so managers often need to develop local application-specific benchmarks. This study developed stream surface fine sediment <2 mm (sand and fines, SF) and macroinvertebrate fine sediment biotic index (FSBI) benchmarks and an application framework to test for sediment-induced macroinvertebrate community composition changes in 1st–4th order Idaho streams. FSBI reference benchmarks were calculated as the 25th percentile FSBI value among reference sites within three ecoregion-based site classes. Two approaches were used to develop SF benchmarks. Quantile regression was used to define reach-specific SF benchmarks representing an upper bound value expected under reference conditions. In addition, logistic regression was used to predict SF values with 50% and 75% probability that FSBI is worse than reference within each stream order and site class. The strength of association between SF benchmarks and macroinvertebrate community condition was evaluated by calculating relative risk using multiple datasets and examining responses of multiple macroinvertebrate indicators to SF benchmark status. SF reference benchmarks generally had stronger associations with poor macroinvertebrate condition than SF stressor-response benchmarks. Across datasets and macroinvertebrate indicators, poor macroinvertebrate condition was 1.8–3 times more likely when SF reference benchmarks were exceeded than when achieved. We propose rating the strength of evidence for a surface fine sediment-induced macroinvertebrate community composition change at the sample event scale as ‘unlikely’ if both SF and FSBI reference benchmarks are achieved, having ‘mixed evidence’ if only one reference benchmark is achieved, and ‘likely’ if both reference benchmarks are not achieved…
format: application/pdf
format: text/html
creator: Jason Williams
creator: James Efta
subject: Ecology
subject: Freshwater Biology
subject: Natural Resource Management
subject: Environmental Impacts
description: doi:10.7717/peerj.18060
publisher: PeerJ Inc.
rights: © 2024 Williams and Efta
abstract: Human activities can increase sediment delivery to streams, changing the composition, distribution, and abundance of stream aquatic life. Few U.S. states have numeric water quality standards for streambed sediment under the Clean Water Act, so managers often need to develop local application-specific benchmarks. This study developed stream surface fine sediment <2 mm (sand and fines, SF) and macroinvertebrate fine sediment biotic index (FSBI) benchmarks and an application framework to test for sediment-induced macroinvertebrate community composition changes in 1st–4th order Idaho streams. FSBI reference benchmarks were calculated as the 25th percentile FSBI value among reference sites within three ecoregion-based site classes. Two approaches were used to develop SF benchmarks. Quantile regression was used to define reach-specific SF benchmarks representing an upper bound value expected under reference conditions. In addition, logistic regression was used to predict SF values with 50% and 75% probability that FSBI is worse than reference within each stream order and site class. The strength of association between SF benchmarks and macroinvertebrate community condition was evaluated by calculating relative risk using multiple datasets and examining responses of multiple macroinvertebrate indicators to SF benchmark status. SF reference benchmarks generally had stronger associations with poor macroinvertebrate condition than SF stressor-response benchmarks. Across datasets and macroinvertebrate indicators, poor macroinvertebrate condition was 1.8–3 times more likely when SF reference benchmarks were exceeded than when achieved. We propose rating the strength of evidence for a surface fine sediment-induced macroinvertebrate community composition change at the sample event scale as ‘unlikely’ if both SF and FSBI reference benchmarks are achieved, having ‘mixed evidence’ if only one reference benchmark is achieved, and ‘likely’ if both reference benchmarks are not achieved…
bibliographic citation: Williams et al. (2024) A method for evaluating sediment-induced macroinvertebrate community composition changes in Idaho streams. PeerJ 12:e18060 https://doi.org/10.7717/peerj.18060
date submitted: 2024-06-18
date accepted: 2024-08-17
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Williams
  given name: Jason
author list: Agent
  family name: Efta
  given name: James
doi: 10.7717/peerj.18060
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: © 2024 Williams and Efta
attribution name: Williams and Efta

https://peerj.com/articles/18126
type: item
type: AcademicArticle
title: Beyond graft function impairment after liver transplantation: the prolonged cold ischemia time impact on recurrence of hepatocellular carcinoma after liver transplantation—a single-center retrospective study
description: Purpose Hepatocellular carcinoma (HCC) is one of the malignant tumors responsible for high mortality and recurrence rates. Although liver transplantation (LT) is an effective treatment option for HCC, ischemia-reperfusion injury (IRI) is a contributor to HCC recurrence after LT. Moreover, prolonged cold ischemia time (CIT) is a risk factor for IRI during LT, and there is insufficient clinical evidence regarding the impact of CIT on HCC recurrence after LT. Patients and Methods This retrospective study analyzed 420 patients who underwent LT for HCC between February 2015 and November 2020 at The First Affiliated Hospital, Sun Yat-sen University. The duration of CIT was defined as the time from clamping of the donor aorta until portal reperfusion. Results A total of 133 patients (31.7%) experienced tumor recurrence after LT, and CIT > 568 min was the independent risk factor for HCC recurrence (OR, 2.406; 95% CI [1.371–4.220]; p = 0.002). Multivariate Cox’s regression analysis revealed that the recipients’ gender, exceeding Milan criteria, poor differentiation, and alpha-fetoprotein (AFP) ≥400 ng/ml in CIT > 568 min group were independent risk factors for disease-free survival. The peak 7-day postoperative alanine aminotransferase (ALT) level (p < 0.001), the peak 7-day postoperative aspartate aminotransferase (AST) level (p < 0.001), the peak 7-day postoperative peak total bilirubin (TBIL) level (p = 0.012), and the incidence of early allograft dysfunction (EAD) (p = 0.006) were significantly higher in the CIT > 568 min group compared to the CIT ≤ 568 min group. Moreover, the amount of fresh frozen plasma (FFP) infusion during the operation increased (p = 0.02), and the time of mechanical ventilation postoperative was longer (p = 0.045). Conclusion An effective strategy to improve the prognosis is to reduce CIT; this strategy lowers the recurrence of HCC in patients undergoing LT, especially those within the Milan criteria.
format: application/pdf
format: text/html
creator: Jia Yu
creator: Tang Yunhua
creator: Yiwen Guo
creator: Yuqi Dong
creator: Jin long Gong
creator: Tielong Wang
creator: Zhitao Chen
creator: Maogen Chen
creator: Weiqiang Ju
creator: Xiaoshun He
subject: Gastroenterology and Hepatology
subject: Oncology
subject: Surgery and Surgical Specialties
description: doi:10.7717/peerj.18126
publisher: PeerJ Inc.
rights: © 2024 Yu et al.
abstract: Purpose Hepatocellular carcinoma (HCC) is one of the malignant tumors responsible for high mortality and recurrence rates. Although liver transplantation (LT) is an effective treatment option for HCC, ischemia-reperfusion injury (IRI) is a contributor to HCC recurrence after LT. Moreover, prolonged cold ischemia time (CIT) is a risk factor for IRI during LT, and there is insufficient clinical evidence regarding the impact of CIT on HCC recurrence after LT. Patients and Methods This retrospective study analyzed 420 patients who underwent LT for HCC between February 2015 and November 2020 at The First Affiliated Hospital, Sun Yat-sen University. The duration of CIT was defined as the time from clamping of the donor aorta until portal reperfusion. Results A total of 133 patients (31.7%) experienced tumor recurrence after LT, and CIT > 568 min was the independent risk factor for HCC recurrence (OR, 2.406; 95% CI [1.371–4.220]; p = 0.002). Multivariate Cox’s regression analysis revealed that the recipients’ gender, exceeding Milan criteria, poor differentiation, and alpha-fetoprotein (AFP) ≥400 ng/ml in CIT > 568 min group were independent risk factors for disease-free survival. The peak 7-day postoperative alanine aminotransferase (ALT) level (p < 0.001), the peak 7-day postoperative aspartate aminotransferase (AST) level (p < 0.001), the peak 7-day postoperative peak total bilirubin (TBIL) level (p = 0.012), and the incidence of early allograft dysfunction (EAD) (p = 0.006) were significantly higher in the CIT > 568 min group compared to the CIT ≤ 568 min group. Moreover, the amount of fresh frozen plasma (FFP) infusion during the operation increased (p = 0.02), and the time of mechanical ventilation postoperative was longer (p = 0.045). Conclusion An effective strategy to improve the prognosis is to reduce CIT; this strategy lowers the recurrence of HCC in patients undergoing LT, especially those within the Milan criteria.
bibliographic citation: Yu et al. (2024) Beyond graft function impairment after liver transplantation: the prolonged cold ischemia time impact on recurrence of hepatocellular carcinoma after liver transplantation—a single-center retrospective study. PeerJ 12:e18126 https://doi.org/10.7717/peerj.18126
date submitted: 2023-03-15
date accepted: 2024-08-28
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Yu
  given name: Jia
author list: Agent
  family name: Yunhua
  given name: Tang
author list: Agent
  family name: Guo
  given name: Yiwen
author list: Agent
  family name: Dong
  given name: Yuqi
author list: Agent
  family name: Gong
  given name: Jin long
author list: Agent
  family name: Wang
  given name: Tielong
author list: Agent
  family name: Chen
  given name: Zhitao
author list: Agent
  family name: Chen
  given name: Maogen
author list: Agent
  family name: Ju
  given name: Weiqiang
author list: Agent
  family name: He
  given name: Xiaoshun
doi: 10.7717/peerj.18126
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: ©2024 Yu et al.
attribution name: Yu et al.

Impact of foam rolling with and without vibration on muscle oxidative metabolism and microvascular reactivity
type: item
type: AcademicArticle
description: Background and Purpose There is a growing interest in use vibration foam rolling as a warm up and recovery tool. However, whether vibration foam rolling offers additional benefits to traditional foam rolling is unclear. The current study aims to compare the effects of acute foam rolling, with and without vibration, on skeletal muscle metabolism and microvascular reactivity. Methods Fifteen physically active young males were tested on two different days, with gastrocnemius muscle microvascular function assessed using near-infrared spectroscopy coupled with the post-occlusive reactive hyperemia technique, before and after foam rolling, performed with or without vibration. The slope of tissue saturation index (TSI) decrease during occlusion between 120 s to 150 s (TSI occlusion slope) was assessed for muscle metabolic rate. Three commonly used microvascular function indexes, including the first10s TSI slope after occlusion (TSI10), time for TSI to reach half of peak magnitude (TSI1/2), and TSI peak reactive hyperemia, were also assessed. Results None of the measured indexes showed significance for interaction or method (all p > 0.05). However, there was a main effect for time for TSI occlusion slope, TSI1/2, and TSI peak reactive hyperemia (p = 0.005, 0.034 and 0.046, respectively). No main effect for time for TSI10 was detected (p = 0.963). Conclusions The application of foam rolling can decrease muscle metabolism, and may improve some aspects of muscle microvascular function. However, vibration foam rolling does not seem to offer any additional benefits compared to traditional foam rolling alone.
format: application/pdf
format: text/html
creator: Haizhen Huang
creator: Bin Leng
creator: Chuan Zhang
subject: Anatomy and Physiology
subject: Kinesiology
subject: Biomechanics
subject: Sports Injury
subject: Sports Medicine
description: doi:10.7717/peerj.18180
publisher: PeerJ Inc.
rights: © 2024 Huang et al.
abstract: Background and Purpose There is a growing interest in use vibration foam rolling as a warm up and recovery tool. However, whether vibration foam rolling offers additional benefits to traditional foam rolling is unclear. The current study aims to compare the effects of acute foam rolling, with and without vibration, on skeletal muscle metabolism and microvascular reactivity. Methods Fifteen physically active young males were tested on two different days, with gastrocnemius muscle microvascular function assessed using near-infrared spectroscopy coupled with the post-occlusive reactive hyperemia technique, before and after foam rolling, performed with or without vibration. The slope of tissue saturation index (TSI) decrease during occlusion between 120 s to 150 s (TSI occlusion slope) was assessed for muscle metabolic rate. Three commonly used microvascular function indexes, including the first10s TSI slope after occlusion (TSI10), time for TSI to reach half of peak magnitude (TSI1/2), and TSI peak reactive hyperemia, were also assessed. Results None of the measured indexes showed significance for interaction or method (all p > 0.05). However, there was a main effect for time for TSI occlusion slope, TSI1/2, and TSI peak reactive hyperemia (p = 0.005, 0.034 and 0.046, respectively). No main effect for time for TSI10 was detected (p = 0.963). Conclusions The application of foam rolling can decrease muscle metabolism, and may improve some aspects of muscle microvascular function. However, vibration foam rolling does not seem to offer any additional benefits compared to traditional foam rolling alone.
bibliographic citation: Huang et al. (2024) Impact of foam rolling with and without vibration on muscle oxidative metabolism and microvascular reactivity. PeerJ 12:e18180 https://doi.org/10.7717/peerj.18180
date submitted: 2024-07-10
date accepted: 2024-09-04
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Huang
  given name: Haizhen
author list: Agent
  family name: Leng
  given name: Bin
author list: Agent
  family name: Zhang
  given name: Chuan
doi: 10.7717/peerj.18180
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: ©2024 Huang et al.
attribution name: Huang et al.

Association between triglyceride glycemic index and ejection fraction preserved heart failure in hypertensive patients
type: item
type: AcademicArticle
description: Background The triglyceride-glucose (TyG) index is regarded as an independent predictor of cardiovascular disease consequences and a reliable surrogate measure of insulin resistance (IR). However, the correlation analysis between triglyceride glucose index and heart failure with preserved ejection fraction in patients with essential hypertension remains unknown. Methods A single-center, retrospective study was conducted with patients diagnosed with essential hypertension at the First Affiliated Hospital of Xinjiang Medical University, from December 2018 to September 2020. Participants were selected based on specific inclusion and exclusion criteria, with their clinical data and laboratory tests collected. The study employed Spearman’s correlation analysis, logistic regression models, restricted cubic spline plots, and receiver operating characteristic (ROC) curves to investigate the relationships between the TyG index and HFpEF. Results Out of 1,602 enrolled hypertensive patients, 992 were included in the analysis after applying exclusion criteria. Patients were categorized into tertiles based on the TyG index, which showed that patients in the highest tertile had characteristics associated with a higher risk of HFpEF, including age, body mass index (BMI), systolic blood pressure (SBP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and left ventricular mass index (LVMI). A significant, independent association between the TyG index and HFpEF was confirmed, with an odds ratio (OR) of 5.127 (95% CI [3.894–6.856]). Furthermore, an S-shaped nonlinear relationship was observed between the TyG index and the incidence of HFpEF (nonlinear p < 0.001). TyG index (AUC: 0.824, 95% CI [0.795–0.854]), NT-proBNP (AUC: 0.840, 95% CI [0.816–0.864]), and LVMI (AUC: 0.847, 95% CI [0.820–0.875]) showed good predictive ability for HFpEF. In addition, the TyG+LVMI combination demonstrated the strongest predictive ability (AUC: 0.907, 95% CI [0.887–0.927]). Conclusion The study un…
format: application/pdf
format: text/html
creator: Xue-Feng Shan
creator: Long Yang
creator: Xiao-Ming Gao
subject: Cardiology
subject: Epidemiology
description: doi:10.7717/peerj.18220
publisher: PeerJ Inc.
rights: © 2024 Shan et al.
abstract: Background The triglyceride-glucose (TyG) index is regarded as an independent predictor of cardiovascular disease consequences and a reliable surrogate measure of insulin resistance (IR). However, the correlation analysis between triglyceride glucose index and heart failure with preserved ejection fraction in patients with essential hypertension remains unknown. Methods A single-center, retrospective study was conducted with patients diagnosed with essential hypertension at the First Affiliated Hospital of Xinjiang Medical University, from December 2018 to September 2020. Participants were selected based on specific inclusion and exclusion criteria, with their clinical data and laboratory tests collected. The study employed Spearman’s correlation analysis, logistic regression models, restricted cubic spline plots, and receiver operating characteristic (ROC) curves to investigate the relationships between the TyG index and HFpEF. Results Out of 1,602 enrolled hypertensive patients, 992 were included in the analysis after applying exclusion criteria. Patients were categorized into tertiles based on the TyG index, which showed that patients in the highest tertile had characteristics associated with a higher risk of HFpEF, including age, body mass index (BMI), systolic blood pressure (SBP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and left ventricular mass index (LVMI). A significant, independent association between the TyG index and HFpEF was confirmed, with an odds ratio (OR) of 5.127 (95% CI [3.894–6.856]). Furthermore, an S-shaped nonlinear relationship was observed between the TyG index and the incidence of HFpEF (nonlinear p < 0.001). TyG index (AUC: 0.824, 95% CI [0.795–0.854]), NT-proBNP (AUC: 0.840, 95% CI [0.816–0.864]), and LVMI (AUC: 0.847, 95% CI [0.820–0.875]) showed good predictive ability for HFpEF. In addition, the TyG+LVMI combination demonstrated the strongest predictive ability (AUC: 0.907, 95% CI [0.887–0.927]). Conclusion The study un…
bibliographic citation: Shan et al. (2024) Association between triglyceride glycemic index and ejection fraction preserved heart failure in hypertensive patients. PeerJ 12:e18220 https://doi.org/10.7717/peerj.18220
date submitted: 2024-04-27
date accepted: 2024-09-11
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by-nc/4.0
author list: Agent
  family name: Shan
  given name: Xue-Feng
author list: Agent
  family name: Yang
  given name: Long
author list: Agent
  family name: Gao
  given name: Xiao-Ming
doi: 10.7717/peerj.18220
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: © 2024 Shan et al.
attribution name: Shan et al.

The non-HDL-C to APOB ratio as a predictor of inaccurate LDL-C measurement in patients with chronic intrahepatic cholestasis and jaundice: a retrospective study
type: item
type: AcademicArticle
description: Background Cholestasis is characterized by the accumulation of bile in the liver or biliary system due to obstruction or impaired flow, necessitating lipid profiling to assess lipid metabolism abnormalities. Intrahepatic cholestasis, being the most significant type of cholestasis, further complicates the assessment of lipid abnormalities. However, the accuracy of low-density lipoprotein cholesterol (LDL-C) measurement in intrahepatic cholestasis patients remains uncertain. Objective This study aimed to evaluate the consistency of the homogeneous assay and the Friedewald formula in detecting LDL-C levels and identify factors influencing LDL-C test results in intrahepatic patients with cholestasis. Methods Retrospective analysis of laboratory data was conducted on intrahepatic cholestatic patients. Correlations between LDL-C values obtained using the homogeneous method (LDL-C(D)) and the Friedewald formula (LDL-C(F)), as well as associations between high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1), LDL-C(D) and LDL-C(F), and apolipoprotein B (ApoB), were analyzed. Logistic regression analyses were employed to identify diagnostic indicators for inaccurate LDL-C measurements in intrahepatic cholestatic patients. Results Compared to patients with intrahepatic cholestasis without jaundice, the correlation between LDL-C(F) and LDL-C(D) was weaker in those with jaundice. Additionally, HDL-C exhibited a strong correlation with ApoA1 in both jaundice and non-jaundice cholestasis cases. Elevated non-HDL-C to APOB ratio (NH-C/B Ratio) levels (>4.5) were identified as a reliable predictor of inaccurate LDL-C measurements in patients with chronic intrahepatic cholestasis accompanied by jaundice. Conclusions LDL-C measurement reliability is moderately weaker in patients with intrahepatic cholestasis accompanied by jaundice. Elevated levels of the NH-C/B ratio serve as a significant predictor of inaccurate LDL-C measurements in this chronic patient populat…
format: application/pdf
format: text/html
creator: Yongjiang Cheng
creator: Jingyan Ye
creator: Junyuan Huang
creator: Yang Wang
subject: Biochemistry
subject: Gastroenterology and Hepatology
subject: Metabolic Sciences
description: doi:10.7717/peerj.18224
publisher: PeerJ Inc.
rights: © 2024 Cheng et al.
abstract: Background Cholestasis is characterized by the accumulation of bile in the liver or biliary system due to obstruction or impaired flow, necessitating lipid profiling to assess lipid metabolism abnormalities. Intrahepatic cholestasis, being the most significant type of cholestasis, further complicates the assessment of lipid abnormalities. However, the accuracy of low-density lipoprotein cholesterol (LDL-C) measurement in intrahepatic cholestasis patients remains uncertain. Objective This study aimed to evaluate the consistency of the homogeneous assay and the Friedewald formula in detecting LDL-C levels and identify factors influencing LDL-C test results in intrahepatic patients with cholestasis. Methods Retrospective analysis of laboratory data was conducted on intrahepatic cholestatic patients. Correlations between LDL-C values obtained using the homogeneous method (LDL-C(D)) and the Friedewald formula (LDL-C(F)), as well as associations between high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1), LDL-C(D) and LDL-C(F), and apolipoprotein B (ApoB), were analyzed. Logistic regression analyses were employed to identify diagnostic indicators for inaccurate LDL-C measurements in intrahepatic cholestatic patients. Results Compared to patients with intrahepatic cholestasis without jaundice, the correlation between LDL-C(F) and LDL-C(D) was weaker in those with jaundice. Additionally, HDL-C exhibited a strong correlation with ApoA1 in both jaundice and non-jaundice cholestasis cases. Elevated non-HDL-C to APOB ratio (NH-C/B Ratio) levels (>4.5) were identified as a reliable predictor of inaccurate LDL-C measurements in patients with chronic intrahepatic cholestasis accompanied by jaundice. Conclusions LDL-C measurement reliability is moderately weaker in patients with intrahepatic cholestasis accompanied by jaundice. Elevated levels of the NH-C/B ratio serve as a significant predictor of inaccurate LDL-C measurements in this chronic patient populat…
bibliographic citation: Cheng et al. (2024) The non-HDL-C to APOB ratio as a predictor of inaccurate LDL-C measurement in patients with chronic intrahepatic cholestasis and jaundice: a retrospective study. PeerJ 12:e18224 https://doi.org/10.7717/peerj.18224
date submitted: 2024-05-07
date accepted: 2024-09-12
issued: 2024-10-04
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Cheng
  given name: Yongjiang
author list: Agent
  family name: Ye
  given name: Jingyan
author list: Agent
  family name: Huang
  given name: Junyuan
author list: Agent
  family name: Wang
  given name: Yang
doi: 10.7717/peerj.18224
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-04
copyright: © 2024 Cheng et al.
attribution name: Cheng et al.

Reliability and reproducibility of an Italian questionnaire on “Knowledge of high social impact Eye Diseases” (KED-IT)
type: item
type: AcademicArticle
description: Background Health literacy plays an important role in public health. Although this has been demonstrated in the field of ophthalmology, there are very few specific instruments available to assess eye health literacy. This work aims to develop an Italian questionnaire on knowledge of eye diseases (Knowledge on Eye Disease, Italian version; KED-IT) and to evaluate its reliability and reproducibility. The KED-IT focuses on diseases with high social impact, specifically glaucoma, macular degeneration, diabetic retinopathy and keratoconus, which is the main cause of corneal transplant in Italy. Methods A cross-sectional study was conducted. The KED-IT was self-administered by the study participants twice. The interval between each administration (T0 and T1) was 5 to 8 days. Reliability was assessed using the KR-20 coefficient. The test-retest Cohen’s Kappa coefficient was estimated to measure the stability and reproducibility of the results obtained between T0 and T1. Results A total of 60 subjects participated in the study. The response rate at T1 was 92%. The KR-20 reliability coefficient of the 14-item KED-IT questionnaire was good with a value of 0.878. The Cohen’s kappa value for all 14 items of the KED-IT questionnaire was k = 0.747, indicating good agreement. Conclusions The KED-IT is the first specific ophthalmic knowledge questionnaire validated in the Italian language and we hope that it may be a starting point for the study of eye health literacy in the Italian population.
format: application/pdf
format: text/html
creator: Valeria Iannucci
creator: Alice Bruscolini
creator: Tiziano Melchiorre
creator: Alessandro Lambiase
creator: Alice Mannocci
subject: Ophthalmology
subject: Science and Medical Education
subject: Science Policy
description: doi:10.7717/peerj.17906
publisher: PeerJ Inc.
rights: © 2024 Iannucci et al.
abstract: Background Health literacy plays an important role in public health. Although this has been demonstrated in the field of ophthalmology, there are very few specific instruments available to assess eye health literacy. This work aims to develop an Italian questionnaire on knowledge of eye diseases (Knowledge on Eye Disease, Italian version; KED-IT) and to evaluate its reliability and reproducibility. The KED-IT focuses on diseases with high social impact, specifically glaucoma, macular degeneration, diabetic retinopathy and keratoconus, which is the main cause of corneal transplant in Italy. Methods A cross-sectional study was conducted. The KED-IT was self-administered by the study participants twice. The interval between each administration (T0 and T1) was 5 to 8 days. Reliability was assessed using the KR-20 coefficient. The test-retest Cohen’s Kappa coefficient was estimated to measure the stability and reproducibility of the results obtained between T0 and T1. Results A total of 60 subjects participated in the study. The response rate at T1 was 92%. The KR-20 reliability coefficient of the 14-item KED-IT questionnaire was good with a value of 0.878. The Cohen’s kappa value for all 14 items of the KED-IT questionnaire was k = 0.747, indicating good agreement. Conclusions The KED-IT is the first specific ophthalmic knowledge questionnaire validated in the Italian language and we hope that it may be a starting point for the study of eye health literacy in the Italian population.
bibliographic citation: Iannucci et al. (2024) Reliability and reproducibility of an Italian questionnaire on “Knowledge of high social impact Eye Diseases” (KED-IT). PeerJ 12:e17906 https://doi.org/10.7717/peerj.17906
date submitted: 2024-02-26
date accepted: 2024-07-22
issued: 2024-10-03
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Iannucci
  given name: Valeria
author list: Agent
  family name: Bruscolini
  given name: Alice
author list: Agent
  family name: Melchiorre
  given name: Tiziano
author list: Agent
  family name: Lambiase
  given name: Alessandro
author list: Agent
  family name: Mannocci
  given name: Alice
doi: 10.7717/peerj.17906
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-03
copyright: ©2024 Iannucci et al.
attribution name: Iannucci et al.

Nanotechnology in action: silver nanoparticles for improved eco-friendly remediation
type: item
type: AcademicArticle
description: Nanotechnology is an exciting area with great potential for use in biotechnology due to the far-reaching effects of nanoscale materials and their size-dependent characteristics. Silver and other metal nanoparticles have attracted a lot of attention lately because of the exceptional optical, electrical, and antimicrobial characteristics they possess. Silver nanoparticles (AgNPs) stand out due to their cost-effectiveness and abundant presence in the earth’s crust, making them a compelling subject for further exploration. The vital efficacy of silver nanoparticles in addressing environmental concerns is emphasized in this thorough overview that dives into their significance in environmental remediation. Leveraging the distinctive properties of AgNPs, such as their antibacterial and catalytic characteristics, innovative solutions for efficient treatment of pollutants are being developed. The review critically examines the transformative potential of silver nanoparticles, exploring their various applications and promising achievements in enhancing environmental remediation techniques. As environmental defenders, this study advocates for intensified investigation and application of silver nanoparticles. Furthermore, this review aims to assist future investigators in developing more cost-effective and efficient innovations involving AgNPs carrying nanoprobes. These nanoprobes have the potential to detect numerous groups of contaminants simultaneously, with a low limit of detection (LOD) and reliable reproducibility. The goal is to utilize these innovations for environmental remediation purposes.
format: application/pdf
format: text/html
creator: Suresh Babu Naidu Krishna
creator: Abdul Gaffar Sheik
creator: Karen Pillay
creator: Manhal Ahmed Hamza
creator: Mohammed Yagoub Mohammed Elamir
creator: Samy Selim
subject: Environmental Contamination and Remediation
subject: Environmental Impacts
subject: Green Chemistry
description: doi:10.7717/peerj.18191
publisher: PeerJ Inc.
rights: © 2024 Krishna et al.
abstract: Nanotechnology is an exciting area with great potential for use in biotechnology due to the far-reaching effects of nanoscale materials and their size-dependent characteristics. Silver and other metal nanoparticles have attracted a lot of attention lately because of the exceptional optical, electrical, and antimicrobial characteristics they possess. Silver nanoparticles (AgNPs) stand out due to their cost-effectiveness and abundant presence in the earth’s crust, making them a compelling subject for further exploration. The vital efficacy of silver nanoparticles in addressing environmental concerns is emphasized in this thorough overview that dives into their significance in environmental remediation. Leveraging the distinctive properties of AgNPs, such as their antibacterial and catalytic characteristics, innovative solutions for efficient treatment of pollutants are being developed. The review critically examines the transformative potential of silver nanoparticles, exploring their various applications and promising achievements in enhancing environmental remediation techniques. As environmental defenders, this study advocates for intensified investigation and application of silver nanoparticles. Furthermore, this review aims to assist future investigators in developing more cost-effective and efficient innovations involving AgNPs carrying nanoprobes. These nanoprobes have the potential to detect numerous groups of contaminants simultaneously, with a low limit of detection (LOD) and reliable reproducibility. The goal is to utilize these innovations for environmental remediation purposes.
bibliographic citation: Krishna et al. (2024) Nanotechnology in action: silver nanoparticles for improved eco-friendly remediation. PeerJ 12:e18191 https://doi.org/10.7717/peerj.18191
date submitted: 2024-05-07
date accepted: 2024-09-06
issued: 2024-10-03
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Krishna
  given name: Suresh Babu Naidu
author list: Agent
  family name: Sheik
  given name: Abdul Gaffar
author list: Agent
  family name: Pillay
  given name: Karen
author list: Agent
  family name: Ahmed Hamza
  given name: Manhal
author list: Agent
  family name: Mohammed Elamir
  given name: Mohammed Yagoub
author list: Agent
  family name: Selim
  given name: Samy
doi: 10.7717/peerj.18191
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-03
copyright: © 2024 Krishna et al.
attribution name: Krishna et al.

PotatoG-DKB: a potato gene-disease knowledge base mined from biological literature
type: item
type: AcademicArticle
description: Background Potato is the fourth largest food crop in the world, but potato cultivation faces serious threats from various diseases and pests. Despite significant advancements in research on potato disease resistance, these findings are scattered across numerous publications. For researchers, obtaining relevant knowledge by reading and organizing a large body of literature is a time-consuming and labor-intensive process. Therefore, systematically extracting and organizing the relationships between potato genes and diseases from the literature to establish a potato gene-disease knowledge base is particularly important. Unfortunately, there is currently no such gene-disease knowledge base available. Methods In this study, we constructed a Potato Gene-Disease Knowledge Base (PotatoG-DKB) using natural language processing techniques and large language models. We used PubMed as the data source and obtained 2,906 article abstracts related to potato biology, extracted entities and relationships between potato genes and related disease, and stored them in a Neo4j database. Using web technology, we also constructed the Potato Gene-Disease Knowledge Portal (PotatoG-DKP), an interactive visualization platform. Results PotatoG-DKB encompasses 22 entity types (such as genes, diseases, species, etc.) of 5,206 nodes and 9,443 edges between entities (for example, gene-disease, pathogen-disease, etc.). PotatoG-DKP can intuitively display associative relationships extracted from literature and is a powerful assistant for potato biologists and breeders to understand potato pathogenesis and disease resistance. More details about PotatoG-DKP can be obtained at https://www.potatogd.com.cn/.
format: application/pdf
format: text/html
creator: Congjiao Xie
creator: Jing Gao
creator: Junjie Chen
creator: Xuyang Zhao
subject: Agricultural Science
subject: Bioinformatics
subject: Data Mining and Machine Learning
description: doi:10.7717/peerj.18202
publisher: PeerJ Inc.
rights: © 2024 Xie et al.
abstract: Background Potato is the fourth largest food crop in the world, but potato cultivation faces serious threats from various diseases and pests. Despite significant advancements in research on potato disease resistance, these findings are scattered across numerous publications. For researchers, obtaining relevant knowledge by reading and organizing a large body of literature is a time-consuming and labor-intensive process. Therefore, systematically extracting and organizing the relationships between potato genes and diseases from the literature to establish a potato gene-disease knowledge base is particularly important. Unfortunately, there is currently no such gene-disease knowledge base available. Methods In this study, we constructed a Potato Gene-Disease Knowledge Base (PotatoG-DKB) using natural language processing techniques and large language models. We used PubMed as the data source and obtained 2,906 article abstracts related to potato biology, extracted entities and relationships between potato genes and related disease, and stored them in a Neo4j database. Using web technology, we also constructed the Potato Gene-Disease Knowledge Portal (PotatoG-DKP), an interactive visualization platform. Results PotatoG-DKB encompasses 22 entity types (such as genes, diseases, species, etc.) of 5,206 nodes and 9,443 edges between entities (for example, gene-disease, pathogen-disease, etc.). PotatoG-DKP can intuitively display associative relationships extracted from literature and is a powerful assistant for potato biologists and breeders to understand potato pathogenesis and disease resistance. More details about PotatoG-DKP can be obtained at https://www.potatogd.com.cn/.
bibliographic citation: Xie et al. (2024) PotatoG-DKB: a potato gene-disease knowledge base mined from biological literature. PeerJ 12:e18202 https://doi.org/10.7717/peerj.18202
date submitted: 2024-04-18
date accepted: 2024-09-09
issued: 2024-10-03
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Xie
  given name: Congjiao
author list: Agent
  family name: Gao
  given name: Jing
author list: Agent
  family name: Chen
  given name: Junjie
author list: Agent
  family name: Zhao
  given name: Xuyang
doi: 10.7717/peerj.18202
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-03
copyright: © 2024 Xie et al.
attribution name: Xie et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359