PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: Prioritising non-native fish species for management actions in three Polish rivers using the newly developed tool—dispersal-origin-status-impact scheme
items: FastProtein—an automated software for in silico proteomic analysis
items: Factors influencing health-promoting behavior among single mothers in Northeastern Malaysia: a cross-sectional study
items: Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer
items: The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection
items: Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair
items: Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis
items: Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses
items: The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science
items: Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers

Prioritising non-native fish species for management actions in three Polish rivers using the newly developed tool—dispersal-origin-status-impact scheme
type: item
type: AcademicArticle
description: Background Biological invasions are a major threat to global biodiversity, with freshwater ecosystems being among the most susceptible to the successful establishment of non-native species and their respective potential impacts. In Poland, the introduction and spreading of non-native fish has led to biodiversity loss and ecosystem homogenisation. Methods Our study applies the Dispersal-Origin-Status-Impact (DOSI) assessment scheme, which is a population-level specific assessment that integrates multiple factors, including dispersal mechanisms, origin, status, and impacts, providing a nuanced framework for assessing invasion risks at local and regional levels. We used this tool to evaluate the risks associated with non-native fish species across three major Polish rivers (Pilica, Bzura, and Skrwa Prawa) and to prioritise them for management actions. Results Using DOSI, we assessed eight non-native species identified in the three studied rivers: seven in both Pilica and Bzura and four in Skrwa Prawa. The DOSI assessment scheme identified high variability in the ecological impacts and management priorities among the identified non-native species. Notably, species such as the Ponto-Caspian gobies exhibited higher risk levels due to their rapid spread and considerable ecological effects, contrasting with other species that demonstrated lower impact levels and, hence, received a lower priority for intervention. Conclusion The adoption of the DOSI scheme in three major rivers in Poland has provided valuable insights into the complexities of managing biological invasions, suggesting that localised, detailed assessments are crucial for effective conservation strategies and highlighting the importance of managing non-native populations locally.
format: application/pdf
format: text/html
creator: Dagmara Błońska
creator: Joanna Grabowska
creator: Ali S. Tarkan
creator: Ismael Soto
creator: Phillip J. Haubrock
subject: Biodiversity
subject: Freshwater Biology
subject: Environmental Impacts
description: doi:10.7717/peerj.18300
publisher: PeerJ Inc.
rights: © 2024 Błońska et al.
abstract: Background Biological invasions are a major threat to global biodiversity, with freshwater ecosystems being among the most susceptible to the successful establishment of non-native species and their respective potential impacts. In Poland, the introduction and spreading of non-native fish has led to biodiversity loss and ecosystem homogenisation. Methods Our study applies the Dispersal-Origin-Status-Impact (DOSI) assessment scheme, which is a population-level specific assessment that integrates multiple factors, including dispersal mechanisms, origin, status, and impacts, providing a nuanced framework for assessing invasion risks at local and regional levels. We used this tool to evaluate the risks associated with non-native fish species across three major Polish rivers (Pilica, Bzura, and Skrwa Prawa) and to prioritise them for management actions. Results Using DOSI, we assessed eight non-native species identified in the three studied rivers: seven in both Pilica and Bzura and four in Skrwa Prawa. The DOSI assessment scheme identified high variability in the ecological impacts and management priorities among the identified non-native species. Notably, species such as the Ponto-Caspian gobies exhibited higher risk levels due to their rapid spread and considerable ecological effects, contrasting with other species that demonstrated lower impact levels and, hence, received a lower priority for intervention. Conclusion The adoption of the DOSI scheme in three major rivers in Poland has provided valuable insights into the complexities of managing biological invasions, suggesting that localised, detailed assessments are crucial for effective conservation strategies and highlighting the importance of managing non-native populations locally.
bibliographic citation: Błońska et al. (2024) Prioritising non-native fish species for management actions in three Polish rivers using the newly developed tool—dispersal-origin-status-impact scheme. PeerJ 12:e18300 https://doi.org/10.7717/peerj.18300
date submitted: 2024-07-30
date accepted: 2024-09-23
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Błońska
  given name: Dagmara
author list: Agent
  family name: Grabowska
  given name: Joanna
author list: Agent
  family name: Tarkan
  given name: Ali S.
author list: Agent
  family name: Soto
  given name: Ismael
author list: Agent
  family name: Haubrock
  given name: Phillip J.
doi: 10.7717/peerj.18300
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: ©2024 Błońska et al.
attribution name: Błońska et al.

FastProtein—an automated software for in silico proteomic analysis
type: item
type: AcademicArticle
description: Although various tools provide proteomic information, each tool has limitations related to execution platforms, libraries, versions, and data output format. Integrating data generated from different software is a laborious process that can prolong analysis time. Here, we present FastProtein, a protein analysis pipeline that is user-friendly, easily installable, and outputs important information about subcellular location, transmembrane domains, signal peptide, molecular weight, isoelectric point, hydropathy, aromaticity, gene ontology, endoplasmic reticulum retention domains, and N-glycosylation domains. It also helps determine the presence of glycosylphosphatidylinositol and obtain functional information from InterProScan, PANTHER, Pfam, and alignment-based annotation searches. FastProtein provides the scientific community with an easy-to-use computational tool for proteomic data analysis. It is applicable to both small datasets and proteome-wide studies. It can be used through the command line interface mode or a web interface installed on a local server. FastProtein significantly enhances proteomics analysis workflows by producing multiple results in a single-step process, thereby streamlining and accelerating the overall analysis. The software is open-source and freely available. Installation and execution instructions, as well as the source code and test files generated for tool validation, are available at https://github.com/bioinformatics-ufsc/FastProtein.
format: application/pdf
format: text/html
creator: Renato Simões Moreira
creator: Vilmar Benetti Filho
creator: Guilherme Augusto Maia
creator: Tatiany Aparecida Teixeira Soratto
creator: Eric Kazuo Kawagoe
creator: Bruna Caroline Russi
creator: Luiz Cláudio Miletti
creator: Glauber Wagner
subject: Bioinformatics
subject: Computational Biology
subject: Genomics
description: doi:10.7717/peerj.18309
publisher: PeerJ Inc.
rights: © 2024 Moreira et al.
abstract: Although various tools provide proteomic information, each tool has limitations related to execution platforms, libraries, versions, and data output format. Integrating data generated from different software is a laborious process that can prolong analysis time. Here, we present FastProtein, a protein analysis pipeline that is user-friendly, easily installable, and outputs important information about subcellular location, transmembrane domains, signal peptide, molecular weight, isoelectric point, hydropathy, aromaticity, gene ontology, endoplasmic reticulum retention domains, and N-glycosylation domains. It also helps determine the presence of glycosylphosphatidylinositol and obtain functional information from InterProScan, PANTHER, Pfam, and alignment-based annotation searches. FastProtein provides the scientific community with an easy-to-use computational tool for proteomic data analysis. It is applicable to both small datasets and proteome-wide studies. It can be used through the command line interface mode or a web interface installed on a local server. FastProtein significantly enhances proteomics analysis workflows by producing multiple results in a single-step process, thereby streamlining and accelerating the overall analysis. The software is open-source and freely available. Installation and execution instructions, as well as the source code and test files generated for tool validation, are available at https://github.com/bioinformatics-ufsc/FastProtein.
bibliographic citation: Moreira et al. (2024) FastProtein—an automated software for in silico proteomic analysis. PeerJ 12:e18309 https://doi.org/10.7717/peerj.18309
date submitted: 2024-04-30
date accepted: 2024-09-24
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Moreira
  given name: Renato Simões
author list: Agent
  family name: Benetti Filho
  given name: Vilmar
author list: Agent
  family name: Maia
  given name: Guilherme Augusto
author list: Agent
  family name: Soratto
  given name: Tatiany Aparecida Teixeira
author list: Agent
  family name: Kawagoe
  given name: Eric Kazuo
author list: Agent
  family name: Russi
  given name: Bruna Caroline
author list: Agent
  family name: Miletti
  given name: Luiz Cláudio
author list: Agent
  family name: Wagner
  given name: Glauber
doi: 10.7717/peerj.18309
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: ©2024 Moreira et al.
attribution name: Moreira et al.

Factors influencing health-promoting behavior among single mothers in Northeastern Malaysia: a cross-sectional study
type: item
type: AcademicArticle
description: Introduction Health-promoting behaviors (HPB) play a vital role in maintaining and enhancing overall well-being. Single mothers are at higher risk of cardiovascular disease (CVD) and less involvement in HPB due to psychosocial disadvantages. Objective This study aimed to determine the HPB scores and factors influencing HPB among single mothers in Kelantan (Northeastern, Malaysia). Methods This study employed a cross-sectional design, selecting 242 single mothers from Kelantan through proportional stratified sampling. Data were gathered through questionnaires covering sociodemographic details, the Health-Promoting Lifestyle Profile-II (HPLP-II), the Malay Version of Health Beliefs Related to Cardiovascular Disease (HBCVD-M), and Multidimensional Perceived Social Support (MPSS). The relationships between the dependent variable (HPB) and independent variables were analyzed using multivariable linear regression models. Results The respondents achieved an average HPB score of 118.03 (SD = 19.2), with the highest mean scores in spiritual growth (22.46 [SD = 3.70]) and interpersonal relationships (22.05 [SD = 3.67]). Physical activity had the lowest mean score at 15.09 (SD = 4.62). Significant positive associations were found between HPB and perceived severity of CVD (adjusted β = 1.60; 95% CI [0.68–2.53]; p < 0.001) as well as perceived social support (adjusted β = 0.63; 95% CI [0.37–0.90]; p < 0.001). Conversely, educational level (adjusted β = −10.36; 95% CI [−16.06 to −4.67]; p < 0.001) and perceived benefits of reducing CVD risk (adjusted β = −1.43; 95% CI [−2.37 to −0.48]; p < 0.001) were negatively associated with HPB. Conclusions The findings highlight the importance of health beliefs, social support, and education in shaping HPB among single mothers. Community health initiatives targeting this population should develop strategies to strengthen individuals’ health beliefs and promote a supportive environment.
format: application/pdf
format: text/html
creator: Saidah Adilah Mohamed Yusof
creator: Tengku Alina Tengku Ismail
creator: Kamarul Imran Musa
creator: Hasmaryanti Kamaruzzaman
subject: Public Health
subject: Women’s Health
description: doi:10.7717/peerj.18359
publisher: PeerJ Inc.
rights: © 2024 Mohamed Yusof et al.
abstract: Introduction Health-promoting behaviors (HPB) play a vital role in maintaining and enhancing overall well-being. Single mothers are at higher risk of cardiovascular disease (CVD) and less involvement in HPB due to psychosocial disadvantages. Objective This study aimed to determine the HPB scores and factors influencing HPB among single mothers in Kelantan (Northeastern, Malaysia). Methods This study employed a cross-sectional design, selecting 242 single mothers from Kelantan through proportional stratified sampling. Data were gathered through questionnaires covering sociodemographic details, the Health-Promoting Lifestyle Profile-II (HPLP-II), the Malay Version of Health Beliefs Related to Cardiovascular Disease (HBCVD-M), and Multidimensional Perceived Social Support (MPSS). The relationships between the dependent variable (HPB) and independent variables were analyzed using multivariable linear regression models. Results The respondents achieved an average HPB score of 118.03 (SD = 19.2), with the highest mean scores in spiritual growth (22.46 [SD = 3.70]) and interpersonal relationships (22.05 [SD = 3.67]). Physical activity had the lowest mean score at 15.09 (SD = 4.62). Significant positive associations were found between HPB and perceived severity of CVD (adjusted β = 1.60; 95% CI [0.68–2.53]; p < 0.001) as well as perceived social support (adjusted β = 0.63; 95% CI [0.37–0.90]; p < 0.001). Conversely, educational level (adjusted β = −10.36; 95% CI [−16.06 to −4.67]; p < 0.001) and perceived benefits of reducing CVD risk (adjusted β = −1.43; 95% CI [−2.37 to −0.48]; p < 0.001) were negatively associated with HPB. Conclusions The findings highlight the importance of health beliefs, social support, and education in shaping HPB among single mothers. Community health initiatives targeting this population should develop strategies to strengthen individuals’ health beliefs and promote a supportive environment.
bibliographic citation: Mohamed Yusof et al. (2024) Factors influencing health-promoting behavior among single mothers in Northeastern Malaysia: a cross-sectional study. PeerJ 12:e18359 https://doi.org/10.7717/peerj.18359
date submitted: 2024-06-28
date accepted: 2024-09-28
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Mohamed Yusof
  given name: Saidah Adilah
author list: Agent
  family name: Tengku Ismail
  given name: Tengku Alina
author list: Agent
  family name: Musa
  given name: Kamarul Imran
author list: Agent
  family name: Kamaruzzaman
  given name: Hasmaryanti
doi: 10.7717/peerj.18359
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: ©2024 Mohamed Yusof et al.
attribution name: Mohamed Yusof et al.

Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer
type: item
type: AcademicArticle
description: The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive. This study pioneered a novel TLS quantification system for prognostic and therapeutic response prediction in colorectal carcinoma, alongside a comprehensive depiction of the TLS landscape. Utilizing single-cell sequencing, we established a TLS score within the Tumor Immune Microenvironment (TIME). Analysis of tertiary lymphoid structure-related genes (TLSRGs) in 1,184 patients with colon adenocarcinoma/rectum adenocarcinoma (COADREAD) from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases led to the identification of two distinct molecular subtypes. Differentially expressed genes (DEGs) further segregated these patients into gene subtypes. A TLS score was formulated using gene set variation analysis (GSVA) and its efficacy in predicting immunotherapy outcomes was validated in two independent cohorts. High-scoring patients exhibited a ‘hot’ immune phenotype, correlating with enhanced immunotherapy efficacy. Key genes in our model, including C5AR1, APOE, CYR1P1, and SPP1, were implicated in COADREAD cell proliferation, invasion, and PD-L1 expression. These insights offer a novel approach to colorectal carcinoma treatment, emphasizing TLS targeting as a potential anti-tumor strategy.
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format: text/html
creator: Jinglu Yu
creator: Yabin Gong
creator: Xiaowei Huang
creator: Yufang Bao
subject: Bioinformatics
subject: Oncology
description: doi:10.7717/peerj.18401
publisher: PeerJ Inc.
rights: © 2024 Yu et al.
abstract: The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive. This study pioneered a novel TLS quantification system for prognostic and therapeutic response prediction in colorectal carcinoma, alongside a comprehensive depiction of the TLS landscape. Utilizing single-cell sequencing, we established a TLS score within the Tumor Immune Microenvironment (TIME). Analysis of tertiary lymphoid structure-related genes (TLSRGs) in 1,184 patients with colon adenocarcinoma/rectum adenocarcinoma (COADREAD) from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases led to the identification of two distinct molecular subtypes. Differentially expressed genes (DEGs) further segregated these patients into gene subtypes. A TLS score was formulated using gene set variation analysis (GSVA) and its efficacy in predicting immunotherapy outcomes was validated in two independent cohorts. High-scoring patients exhibited a ‘hot’ immune phenotype, correlating with enhanced immunotherapy efficacy. Key genes in our model, including C5AR1, APOE, CYR1P1, and SPP1, were implicated in COADREAD cell proliferation, invasion, and PD-L1 expression. These insights offer a novel approach to colorectal carcinoma treatment, emphasizing TLS targeting as a potential anti-tumor strategy.
bibliographic citation: Yu et al. (2024) Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer. PeerJ 12:e18401 https://doi.org/10.7717/peerj.18401
date submitted: 2024-06-25
date accepted: 2024-10-04
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Yu
  given name: Jinglu
author list: Agent
  family name: Gong
  given name: Yabin
author list: Agent
  family name: Huang
  given name: Xiaowei
author list: Agent
  family name: Bao
  given name: Yufang
doi: 10.7717/peerj.18401
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Yu et al.
attribution name: Yu et al.

The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection
type: item
type: AcademicArticle
description: Irisin, a product of the post-translational processing of fibronectin type III domain-containing protein 5 (FNDC5), is a novel myokine which is upregulated during exercise. This hormone not only promotes the transformation of white adipose tissue into a brown-fat-like phenotype but also enhances energy expenditure and mitigates fat accumulation. Its role is crucial in the management of certain metabolic disorders such as diabetes and heart disease. Of note, the type of exercise performed significantly affects blood irisin levels, indicating the critical role of physical activity in regulating this hormone. This article aims to summarize the current scientific understanding of the role of irisin and the mechanisms through which it mediates cardiovascular protection through exercise. Moreover, this article aims to establish irisin as a potential target for preventing and treating cardiovascular diseases.
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creator: Wenhuang Guo
creator: Jianwei Peng
creator: Jiarui Su
creator: Jingbo Xia
creator: Weiji Deng
creator: Peilun Li
creator: Yilin Chen
creator: Guoqing Liu
creator: Shen Wang
creator: Junhao Huang
subject: Biochemistry
subject: Molecular Biology
subject: Cardiology
subject: Sports Medicine
description: doi:10.7717/peerj.18413
publisher: PeerJ Inc.
rights: © 2024 Guo et al.
abstract: Irisin, a product of the post-translational processing of fibronectin type III domain-containing protein 5 (FNDC5), is a novel myokine which is upregulated during exercise. This hormone not only promotes the transformation of white adipose tissue into a brown-fat-like phenotype but also enhances energy expenditure and mitigates fat accumulation. Its role is crucial in the management of certain metabolic disorders such as diabetes and heart disease. Of note, the type of exercise performed significantly affects blood irisin levels, indicating the critical role of physical activity in regulating this hormone. This article aims to summarize the current scientific understanding of the role of irisin and the mechanisms through which it mediates cardiovascular protection through exercise. Moreover, this article aims to establish irisin as a potential target for preventing and treating cardiovascular diseases.
bibliographic citation: Guo et al. (2024) The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection. PeerJ 12:e18413 https://doi.org/10.7717/peerj.18413
date submitted: 2024-05-07
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Guo
  given name: Wenhuang
author list: Agent
  family name: Peng
  given name: Jianwei
author list: Agent
  family name: Su
  given name: Jiarui
author list: Agent
  family name: Xia
  given name: Jingbo
author list: Agent
  family name: Deng
  given name: Weiji
author list: Agent
  family name: Li
  given name: Peilun
author list: Agent
  family name: Chen
  given name: Yilin
author list: Agent
  family name: Liu
  given name: Guoqing
author list: Agent
  family name: Wang
  given name: Shen
author list: Agent
  family name: Huang
  given name: Junhao
doi: 10.7717/peerj.18413
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Guo et al.
attribution name: Guo et al.

Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair
type: item
type: AcademicArticle
description: Epidermal stem cells (EpSCs) are crucial for wound healing and tissue regeneration, and traditional culture methods often lead to their inactivation. It is urgent to increase the yield of high quality EpSCs. In this study, primary EpSCs were isolated and cultured in a serum-free, feeder-free culture system. EpSCs are then expanded in a dynamic 3D environment using a rotating cell culture system (RCCS) with biodegradable porous microcarriers (MC). Over a period of 14 days, the cells self-assembled into microtissues with superior cell proliferation compared to 3D static culture. Immunofluorescence and qPCR analyses consistently showed that the stemness of the 3D microtissues was preserved, especially the COL17A1 associated with anti-aging was highly expressed in RCCS induced microtissues. In vivo experiments demonstrated that the group treated with 3D microtissues loaded with EpSCs showed enhanced early wound healing, and the injectable 3D microtissues were more conducive to maintaining cell viability and differentiation potential. Our study provides valuable insights into the dynamic 3D culture of EpSCs and introduces an injectable therapy using 3D microtissues loaded with EpSCs, which provides a new and effective approach for cell delivery and offering a promising strategy for guiding the regeneration of full-thickness skin defects.
format: application/pdf
format: text/html
creator: Min Zhang
creator: Meng Huang
creator: Xixi Dong
creator: Yibo Wang
creator: Luyue Zhang
creator: Zhaoxiang Wang
creator: Junkai Cao
subject: Bioengineering
subject: Cell Biology
subject: Molecular Biology
subject: Dermatology
subject: Histology
description: doi:10.7717/peerj.18418
publisher: PeerJ Inc.
rights: © 2024 Zhang et al.
abstract: Epidermal stem cells (EpSCs) are crucial for wound healing and tissue regeneration, and traditional culture methods often lead to their inactivation. It is urgent to increase the yield of high quality EpSCs. In this study, primary EpSCs were isolated and cultured in a serum-free, feeder-free culture system. EpSCs are then expanded in a dynamic 3D environment using a rotating cell culture system (RCCS) with biodegradable porous microcarriers (MC). Over a period of 14 days, the cells self-assembled into microtissues with superior cell proliferation compared to 3D static culture. Immunofluorescence and qPCR analyses consistently showed that the stemness of the 3D microtissues was preserved, especially the COL17A1 associated with anti-aging was highly expressed in RCCS induced microtissues. In vivo experiments demonstrated that the group treated with 3D microtissues loaded with EpSCs showed enhanced early wound healing, and the injectable 3D microtissues were more conducive to maintaining cell viability and differentiation potential. Our study provides valuable insights into the dynamic 3D culture of EpSCs and introduces an injectable therapy using 3D microtissues loaded with EpSCs, which provides a new and effective approach for cell delivery and offering a promising strategy for guiding the regeneration of full-thickness skin defects.
bibliographic citation: Zhang et al. (2024) Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair. PeerJ 12:e18418 https://doi.org/10.7717/peerj.18418
date submitted: 2024-03-26
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Zhang
  given name: Min
author list: Agent
  family name: Huang
  given name: Meng
author list: Agent
  family name: Dong
  given name: Xixi
author list: Agent
  family name: Wang
  given name: Yibo
author list: Agent
  family name: Zhang
  given name: Luyue
author list: Agent
  family name: Wang
  given name: Zhaoxiang
author list: Agent
  family name: Cao
  given name: Junkai
doi: 10.7717/peerj.18418
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Zhang et al.
attribution name: Zhang et al.

Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis
type: item
type: AcademicArticle
description: Objective The purpose of the present study was to evaluate whether intravenous immunoglobulin (IVIG) increases live birth rates and improves neonatal results in patients with antiphospholipid antibodies (aPL) at high-risk for miscarriage. Background Positivity of aPL in pregnant women is a high-risk factor for miscarriage, and IVIG treatment has emerged as a potential intervention. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was employed to search multiple electronic databases for articles published until August 20, 2023, including PubMed, Web of Science, Embase, Scopus and Medline. The inclusion criteria encompassed studies assessing the efficacy of IVIG in aPL-positive patients with a high risk of miscarriage. Relevant articles were assessed for the quality and data were extracted for analysis. Two independent reviewers performed study selection, data extraction, and quality assessments. The risk of bias was evaluated according to the Cochrane risk of bias tool. All analyses were conducted using Review Manager 5.3. Results This systematic review included nine randomized controlled trials, with 366 aPL-positive women at high risk of miscarriage. These studies included in this review were randomized controlled trials. The primary outcome measures were successful pregnancy outcomes and live birth rates. The secondary outcomes included obstetric complications, and neonatal outcomes (such as birth weight and live-birth rate). The comparison between the intervention and control groups revealed no significant differences in terms of obstetric complications and neonatal outcomes. The group receiving IVIG treatment had a higher prevalence of preterm deliveries than controls (OR = 2.05, I2 = 46%, 95% CI [0.58–5.24]), but also exhibited a partial improvement in live birth rates (OR = 2.86, I2 = 52%, 95% CI [1.04–7.90]), because it reduced the number of miscarriages (OR = 0.35, I2 = 52%, 95% CI [0.13–0.96]). Conclusion Bas…
format: application/pdf
format: text/html
creator: Xin Yuan
creator: Wei Zhang
creator: Tong Wang
creator: Peng Jiang
creator: Zong-kui Wang
creator: Chang-qing Li
subject: Allergy and Clinical Immunology
subject: Clinical Trials
subject: Drugs and Devices
subject: Gynecology and Obstetrics
description: doi:10.7717/peerj.18419
publisher: PeerJ Inc.
rights: © 2024 Yuan et al.
abstract: Objective The purpose of the present study was to evaluate whether intravenous immunoglobulin (IVIG) increases live birth rates and improves neonatal results in patients with antiphospholipid antibodies (aPL) at high-risk for miscarriage. Background Positivity of aPL in pregnant women is a high-risk factor for miscarriage, and IVIG treatment has emerged as a potential intervention. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was employed to search multiple electronic databases for articles published until August 20, 2023, including PubMed, Web of Science, Embase, Scopus and Medline. The inclusion criteria encompassed studies assessing the efficacy of IVIG in aPL-positive patients with a high risk of miscarriage. Relevant articles were assessed for the quality and data were extracted for analysis. Two independent reviewers performed study selection, data extraction, and quality assessments. The risk of bias was evaluated according to the Cochrane risk of bias tool. All analyses were conducted using Review Manager 5.3. Results This systematic review included nine randomized controlled trials, with 366 aPL-positive women at high risk of miscarriage. These studies included in this review were randomized controlled trials. The primary outcome measures were successful pregnancy outcomes and live birth rates. The secondary outcomes included obstetric complications, and neonatal outcomes (such as birth weight and live-birth rate). The comparison between the intervention and control groups revealed no significant differences in terms of obstetric complications and neonatal outcomes. The group receiving IVIG treatment had a higher prevalence of preterm deliveries than controls (OR = 2.05, I2 = 46%, 95% CI [0.58–5.24]), but also exhibited a partial improvement in live birth rates (OR = 2.86, I2 = 52%, 95% CI [1.04–7.90]), because it reduced the number of miscarriages (OR = 0.35, I2 = 52%, 95% CI [0.13–0.96]). Conclusion Bas…
bibliographic citation: Yuan et al. (2024) Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis. PeerJ 12:e18419 https://doi.org/10.7717/peerj.18419
date submitted: 2024-06-28
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Yuan
  given name: Xin
author list: Agent
  family name: Zhang
  given name: Wei
author list: Agent
  family name: Wang
  given name: Tong
author list: Agent
  family name: Jiang
  given name: Peng
author list: Agent
  family name: Wang
  given name: Zong-kui
author list: Agent
  family name: Li
  given name: Chang-qing
doi: 10.7717/peerj.18419
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Yuan et al.
attribution name: Yuan et al.

Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses
type: item
type: AcademicArticle
description: Introduction In Africa, healthcare professionals experienced various mental health problems during COVID-19. However, very little was done on the extensive evidence regarding mental disorders. The purpose of this umbrella review is to provide comprehensive data on the prevalence of anxiety, depression, stress, and insomnia among healthcare professionals during the COVID-19 pandemic in Africa. Materials and Methods Systematic searches of databases African Journals Online, MedRxiv, PubMed, and Google Scholar were used to identify studies from the occurrence of COVID-19 from December 2019 to March 2023 were included. To pool the gathered data for results with a 95% confidence interval (CI), DerSimonian-Laird random effects meta-analysis was used. For heterogeneity examination, I2 was used. The quality assessment was evaluated by using the Joanna Briggs Institute (JBI) critical appraisal checklist. Results A total of five studies reported the prevalence of depression, the pooled prevalence was 53.75% (95% CI [40.80–66.70], I2 = 63.6%, p = 0.027). In a total of four studies, the pooled prevalence of anxiety was 49.97% (95% CI [34.71–65.23], I2 = 71.26%, p = 0.014). From a total of two studies, the pooled prevalence of stress was 57.27% (95% CI [42.28–72.25], I2 = 58.9%, p = 0.119). From a total of four studies, the pooled prevalence of insomnia was 45.16% (95% CI [32.94–57.39], I2 = 50.8%, p = 0.107). Conclusions The COVID-19 pandemic highly affects the mental health of healthcare professionals in Africa. Stress, depression, anxiety, and insomnia symptoms were representing the most common based on evidences from existing meta-analyses. This evidence can help experts when executing specific interventions that address mental health problems among healthcare professionals during future public health crises.
format: application/pdf
format: text/html
creator: Aragaw Asfaw Hasen
creator: Ahmed Adem Mohammed
creator: Abubeker Alebachew Seid
subject: Evidence Based Medicine
subject: Global Health
subject: Nursing
subject: Mental Health
subject: COVID-19
description: doi:10.7717/peerj.18108
publisher: PeerJ Inc.
rights: © 2024 Hasen et al.
abstract: Introduction In Africa, healthcare professionals experienced various mental health problems during COVID-19. However, very little was done on the extensive evidence regarding mental disorders. The purpose of this umbrella review is to provide comprehensive data on the prevalence of anxiety, depression, stress, and insomnia among healthcare professionals during the COVID-19 pandemic in Africa. Materials and Methods Systematic searches of databases African Journals Online, MedRxiv, PubMed, and Google Scholar were used to identify studies from the occurrence of COVID-19 from December 2019 to March 2023 were included. To pool the gathered data for results with a 95% confidence interval (CI), DerSimonian-Laird random effects meta-analysis was used. For heterogeneity examination, I2 was used. The quality assessment was evaluated by using the Joanna Briggs Institute (JBI) critical appraisal checklist. Results A total of five studies reported the prevalence of depression, the pooled prevalence was 53.75% (95% CI [40.80–66.70], I2 = 63.6%, p = 0.027). In a total of four studies, the pooled prevalence of anxiety was 49.97% (95% CI [34.71–65.23], I2 = 71.26%, p = 0.014). From a total of two studies, the pooled prevalence of stress was 57.27% (95% CI [42.28–72.25], I2 = 58.9%, p = 0.119). From a total of four studies, the pooled prevalence of insomnia was 45.16% (95% CI [32.94–57.39], I2 = 50.8%, p = 0.107). Conclusions The COVID-19 pandemic highly affects the mental health of healthcare professionals in Africa. Stress, depression, anxiety, and insomnia symptoms were representing the most common based on evidences from existing meta-analyses. This evidence can help experts when executing specific interventions that address mental health problems among healthcare professionals during future public health crises.
bibliographic citation: Hasen et al. (2024) Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses. PeerJ 12:e18108 https://doi.org/10.7717/peerj.18108
date submitted: 2024-02-12
date accepted: 2024-08-27
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Hasen
  given name: Aragaw Asfaw
author list: Agent
  family name: Mohammed
  given name: Ahmed Adem
author list: Agent
  family name: Seid
  given name: Abubeker Alebachew
doi: 10.7717/peerj.18108
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Hasen et al.
attribution name: Hasen et al.

The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science
type: item
type: AcademicArticle
description: Argyreia Lour. is a speciose genus in the Convolvulaceae. However, the genus contains several problematic species complexes due to their morphological similarity. In this study, we aimed to resolve the Argyreia collinsiae complex, which consists of four similar operational taxonomic units (OTUs), i.e., A. collinsiae (Craib) Na Songkhla & Traiperm, A. dokmaihom Traiperm & Staples, A. versicolor (Kerr) Staples & Traiperm, and a peculiar OTU typically known as the large-bract morphotype of A. collinsiae. Following morphological comparison and phenetic analysis, all four OTUs were found to be distinct. However, the large-bract morphotype of A. collinsiae was confirmed to be more closely related to the original morphotype of A. collinsiae than to the other two species. Species distribution modeling (SDM) was then conducted for both morphotypes of A. collinsiae, revealing different geographical ranges of suitable habitat for each. In conclusion, the large-bract morphotype of A. collinsiae was described in this study as a new subspecies, A. collinsiae subsp. megabracteata Traiperm & Srisombat, subsp. nov., based on morphological differences and separate geographic range. We also provide here an identification key, description, detailed illustrations, distribution data, and ecological notes of the new subspecies. An updated description of A. versicolor and an assessment of its conservation status were also prepared since the original description was based solely on dried herbarium specimens and lacks key details.
format: application/pdf
format: text/html
creator: Poompat Srisombat
creator: Natthaphong Chitchak
creator: Pantamith Rattanakrajang
creator: Alyssa B. Stewart
creator: Paweena Traiperm
subject: Biodiversity
subject: Plant Science
subject: Taxonomy
description: doi:10.7717/peerj.18294
publisher: PeerJ Inc.
rights: © 2024 Srisombat et al.
abstract: Argyreia Lour. is a speciose genus in the Convolvulaceae. However, the genus contains several problematic species complexes due to their morphological similarity. In this study, we aimed to resolve the Argyreia collinsiae complex, which consists of four similar operational taxonomic units (OTUs), i.e., A. collinsiae (Craib) Na Songkhla & Traiperm, A. dokmaihom Traiperm & Staples, A. versicolor (Kerr) Staples & Traiperm, and a peculiar OTU typically known as the large-bract morphotype of A. collinsiae. Following morphological comparison and phenetic analysis, all four OTUs were found to be distinct. However, the large-bract morphotype of A. collinsiae was confirmed to be more closely related to the original morphotype of A. collinsiae than to the other two species. Species distribution modeling (SDM) was then conducted for both morphotypes of A. collinsiae, revealing different geographical ranges of suitable habitat for each. In conclusion, the large-bract morphotype of A. collinsiae was described in this study as a new subspecies, A. collinsiae subsp. megabracteata Traiperm & Srisombat, subsp. nov., based on morphological differences and separate geographic range. We also provide here an identification key, description, detailed illustrations, distribution data, and ecological notes of the new subspecies. An updated description of A. versicolor and an assessment of its conservation status were also prepared since the original description was based solely on dried herbarium specimens and lacks key details.
bibliographic citation: Srisombat et al. (2024) The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science. PeerJ 12:e18294 https://doi.org/10.7717/peerj.18294
date submitted: 2024-04-16
date accepted: 2024-09-21
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Srisombat
  given name: Poompat
author list: Agent
  family name: Chitchak
  given name: Natthaphong
author list: Agent
  family name: Rattanakrajang
  given name: Pantamith
author list: Agent
  family name: Stewart
  given name: Alyssa B.
author list: Agent
  family name: Traiperm
  given name: Paweena
doi: 10.7717/peerj.18294
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Srisombat et al.
attribution name: Srisombat et al.

Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers
type: item
type: AcademicArticle
description: Objectives To investigate the effects of integrative neuromuscular training (INT) on the athletic performance of elite female boxers. Methods A before-and-after controlled experiment was conducted on 37 elite Chinese female boxers (Age: 26.00 ± 3.11 years). All included athletes have competed at the international level. The INT intervention was administered 11 times per week for 3 weeks. This training includes strength training, explosive training, core stability, agility exercises, high intensity intervals and sprint intervals. Basic physical fitness tests, including the deep squat and bench press one-repetition maximum (1RM), vertical long jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake; as well as specialized striking ability tests, including single-punch striking and 10-second, 30-second, and 3-minute continuous punching, were conducted before and after the intervention. Results Compared with pre-intervention baseline data, significant differences were found in the athletes’ post-intervention baseline physical fitness, including squat and beach press (1RM), vertical jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake (p < 0.05). Additionally, 10-second, 30-second, and 3-minute continuous punching were significantly different compared with pre-intervention (p < 0.05). However, no significant differences were found in single punch power (p > 0.05). Conclusion The 3-week INT can significantly improve the maximum strength, vertical explosive power, linear acceleration, agility, and continuous punching abilities of Chinese elite female boxers. The use of INT in physical training may enhance their athletic performance.
format: application/pdf
format: text/html
creator: Zhen Niu
creator: Zijing Huang
creator: Gan Zhao
creator: Chao Chen
subject: Kinesiology
subject: Biomechanics
subject: Sports Injury
subject: Sports Medicine
description: doi:10.7717/peerj.18311
publisher: PeerJ Inc.
rights: © 2024 Niu et al.
abstract: Objectives To investigate the effects of integrative neuromuscular training (INT) on the athletic performance of elite female boxers. Methods A before-and-after controlled experiment was conducted on 37 elite Chinese female boxers (Age: 26.00 ± 3.11 years). All included athletes have competed at the international level. The INT intervention was administered 11 times per week for 3 weeks. This training includes strength training, explosive training, core stability, agility exercises, high intensity intervals and sprint intervals. Basic physical fitness tests, including the deep squat and bench press one-repetition maximum (1RM), vertical long jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake; as well as specialized striking ability tests, including single-punch striking and 10-second, 30-second, and 3-minute continuous punching, were conducted before and after the intervention. Results Compared with pre-intervention baseline data, significant differences were found in the athletes’ post-intervention baseline physical fitness, including squat and beach press (1RM), vertical jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake (p < 0.05). Additionally, 10-second, 30-second, and 3-minute continuous punching were significantly different compared with pre-intervention (p < 0.05). However, no significant differences were found in single punch power (p > 0.05). Conclusion The 3-week INT can significantly improve the maximum strength, vertical explosive power, linear acceleration, agility, and continuous punching abilities of Chinese elite female boxers. The use of INT in physical training may enhance their athletic performance.
bibliographic citation: Niu et al. (2024) Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers. PeerJ 12:e18311 https://doi.org/10.7717/peerj.18311
date submitted: 2024-06-17
date accepted: 2024-09-24
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Niu
  given name: Zhen
author list: Agent
  family name: Huang
  given name: Zijing
author list: Agent
  family name: Zhao
  given name: Gan
author list: Agent
  family name: Chen
  given name: Chao
doi: 10.7717/peerj.18311
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Niu et al.
attribution name: Niu et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359