PeerJ
type: channel
link: https://peerj.com/articles/
description: Articles published in PeerJ
publisher: PeerJ Inc.
publication name: PeerJ
issn: 2167-8359
items: The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection
items: Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair
items: Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis
items: Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses
items: The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science
items: Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers
items: Research progress on V delta 1+ T cells and their effect on pathogen infection
items: Meta-analysis of the efficacy of the erector spinae plane block after spinal fusion surgery
items: The critical need for child and youth perceptions of active living in India: capturing context complexity in rural and urban regions
items: Differences in cardiovascular disease mortality between northern and southern China under exposure to different temperatures: a systematic review

The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection
type: item
type: AcademicArticle
description: Irisin, a product of the post-translational processing of fibronectin type III domain-containing protein 5 (FNDC5), is a novel myokine which is upregulated during exercise. This hormone not only promotes the transformation of white adipose tissue into a brown-fat-like phenotype but also enhances energy expenditure and mitigates fat accumulation. Its role is crucial in the management of certain metabolic disorders such as diabetes and heart disease. Of note, the type of exercise performed significantly affects blood irisin levels, indicating the critical role of physical activity in regulating this hormone. This article aims to summarize the current scientific understanding of the role of irisin and the mechanisms through which it mediates cardiovascular protection through exercise. Moreover, this article aims to establish irisin as a potential target for preventing and treating cardiovascular diseases.
format: application/pdf
format: text/html
creator: Wenhuang Guo
creator: Jianwei Peng
creator: Jiarui Su
creator: Jingbo Xia
creator: Weiji Deng
creator: Peilun Li
creator: Yilin Chen
creator: Guoqing Liu
creator: Shen Wang
creator: Junhao Huang
subject: Biochemistry
subject: Molecular Biology
subject: Cardiology
subject: Sports Medicine
description: doi:10.7717/peerj.18413
publisher: PeerJ Inc.
rights: © 2024 Guo et al.
abstract: Irisin, a product of the post-translational processing of fibronectin type III domain-containing protein 5 (FNDC5), is a novel myokine which is upregulated during exercise. This hormone not only promotes the transformation of white adipose tissue into a brown-fat-like phenotype but also enhances energy expenditure and mitigates fat accumulation. Its role is crucial in the management of certain metabolic disorders such as diabetes and heart disease. Of note, the type of exercise performed significantly affects blood irisin levels, indicating the critical role of physical activity in regulating this hormone. This article aims to summarize the current scientific understanding of the role of irisin and the mechanisms through which it mediates cardiovascular protection through exercise. Moreover, this article aims to establish irisin as a potential target for preventing and treating cardiovascular diseases.
bibliographic citation: Guo et al. (2024) The role and underlying mechanisms of irisin in exercise-mediated cardiovascular protection. PeerJ 12:e18413 https://doi.org/10.7717/peerj.18413
date submitted: 2024-05-07
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Guo
  given name: Wenhuang
author list: Agent
  family name: Peng
  given name: Jianwei
author list: Agent
  family name: Su
  given name: Jiarui
author list: Agent
  family name: Xia
  given name: Jingbo
author list: Agent
  family name: Deng
  given name: Weiji
author list: Agent
  family name: Li
  given name: Peilun
author list: Agent
  family name: Chen
  given name: Yilin
author list: Agent
  family name: Liu
  given name: Guoqing
author list: Agent
  family name: Wang
  given name: Shen
author list: Agent
  family name: Huang
  given name: Junhao
doi: 10.7717/peerj.18413
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Guo et al.
attribution name: Guo et al.

Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair
type: item
type: AcademicArticle
description: Epidermal stem cells (EpSCs) are crucial for wound healing and tissue regeneration, and traditional culture methods often lead to their inactivation. It is urgent to increase the yield of high quality EpSCs. In this study, primary EpSCs were isolated and cultured in a serum-free, feeder-free culture system. EpSCs are then expanded in a dynamic 3D environment using a rotating cell culture system (RCCS) with biodegradable porous microcarriers (MC). Over a period of 14 days, the cells self-assembled into microtissues with superior cell proliferation compared to 3D static culture. Immunofluorescence and qPCR analyses consistently showed that the stemness of the 3D microtissues was preserved, especially the COL17A1 associated with anti-aging was highly expressed in RCCS induced microtissues. In vivo experiments demonstrated that the group treated with 3D microtissues loaded with EpSCs showed enhanced early wound healing, and the injectable 3D microtissues were more conducive to maintaining cell viability and differentiation potential. Our study provides valuable insights into the dynamic 3D culture of EpSCs and introduces an injectable therapy using 3D microtissues loaded with EpSCs, which provides a new and effective approach for cell delivery and offering a promising strategy for guiding the regeneration of full-thickness skin defects.
format: application/pdf
format: text/html
creator: Min Zhang
creator: Meng Huang
creator: Xixi Dong
creator: Yibo Wang
creator: Luyue Zhang
creator: Zhaoxiang Wang
creator: Junkai Cao
subject: Bioengineering
subject: Cell Biology
subject: Molecular Biology
subject: Dermatology
subject: Histology
description: doi:10.7717/peerj.18418
publisher: PeerJ Inc.
rights: © 2024 Zhang et al.
abstract: Epidermal stem cells (EpSCs) are crucial for wound healing and tissue regeneration, and traditional culture methods often lead to their inactivation. It is urgent to increase the yield of high quality EpSCs. In this study, primary EpSCs were isolated and cultured in a serum-free, feeder-free culture system. EpSCs are then expanded in a dynamic 3D environment using a rotating cell culture system (RCCS) with biodegradable porous microcarriers (MC). Over a period of 14 days, the cells self-assembled into microtissues with superior cell proliferation compared to 3D static culture. Immunofluorescence and qPCR analyses consistently showed that the stemness of the 3D microtissues was preserved, especially the COL17A1 associated with anti-aging was highly expressed in RCCS induced microtissues. In vivo experiments demonstrated that the group treated with 3D microtissues loaded with EpSCs showed enhanced early wound healing, and the injectable 3D microtissues were more conducive to maintaining cell viability and differentiation potential. Our study provides valuable insights into the dynamic 3D culture of EpSCs and introduces an injectable therapy using 3D microtissues loaded with EpSCs, which provides a new and effective approach for cell delivery and offering a promising strategy for guiding the regeneration of full-thickness skin defects.
bibliographic citation: Zhang et al. (2024) Rotating cell culture system-induced injectable self-assembled microtissues with epidermal stem cells for full-thickness skin repair. PeerJ 12:e18418 https://doi.org/10.7717/peerj.18418
date submitted: 2024-03-26
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Zhang
  given name: Min
author list: Agent
  family name: Huang
  given name: Meng
author list: Agent
  family name: Dong
  given name: Xixi
author list: Agent
  family name: Wang
  given name: Yibo
author list: Agent
  family name: Zhang
  given name: Luyue
author list: Agent
  family name: Wang
  given name: Zhaoxiang
author list: Agent
  family name: Cao
  given name: Junkai
doi: 10.7717/peerj.18418
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Zhang et al.
attribution name: Zhang et al.

Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis
type: item
type: AcademicArticle
description: Objective The purpose of the present study was to evaluate whether intravenous immunoglobulin (IVIG) increases live birth rates and improves neonatal results in patients with antiphospholipid antibodies (aPL) at high-risk for miscarriage. Background Positivity of aPL in pregnant women is a high-risk factor for miscarriage, and IVIG treatment has emerged as a potential intervention. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was employed to search multiple electronic databases for articles published until August 20, 2023, including PubMed, Web of Science, Embase, Scopus and Medline. The inclusion criteria encompassed studies assessing the efficacy of IVIG in aPL-positive patients with a high risk of miscarriage. Relevant articles were assessed for the quality and data were extracted for analysis. Two independent reviewers performed study selection, data extraction, and quality assessments. The risk of bias was evaluated according to the Cochrane risk of bias tool. All analyses were conducted using Review Manager 5.3. Results This systematic review included nine randomized controlled trials, with 366 aPL-positive women at high risk of miscarriage. These studies included in this review were randomized controlled trials. The primary outcome measures were successful pregnancy outcomes and live birth rates. The secondary outcomes included obstetric complications, and neonatal outcomes (such as birth weight and live-birth rate). The comparison between the intervention and control groups revealed no significant differences in terms of obstetric complications and neonatal outcomes. The group receiving IVIG treatment had a higher prevalence of preterm deliveries than controls (OR = 2.05, I2 = 46%, 95% CI [0.58–5.24]), but also exhibited a partial improvement in live birth rates (OR = 2.86, I2 = 52%, 95% CI [1.04–7.90]), because it reduced the number of miscarriages (OR = 0.35, I2 = 52%, 95% CI [0.13–0.96]). Conclusion Bas…
format: application/pdf
format: text/html
creator: Xin Yuan
creator: Wei Zhang
creator: Tong Wang
creator: Peng Jiang
creator: Zong-kui Wang
creator: Chang-qing Li
subject: Allergy and Clinical Immunology
subject: Clinical Trials
subject: Drugs and Devices
subject: Gynecology and Obstetrics
description: doi:10.7717/peerj.18419
publisher: PeerJ Inc.
rights: © 2024 Yuan et al.
abstract: Objective The purpose of the present study was to evaluate whether intravenous immunoglobulin (IVIG) increases live birth rates and improves neonatal results in patients with antiphospholipid antibodies (aPL) at high-risk for miscarriage. Background Positivity of aPL in pregnant women is a high-risk factor for miscarriage, and IVIG treatment has emerged as a potential intervention. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was employed to search multiple electronic databases for articles published until August 20, 2023, including PubMed, Web of Science, Embase, Scopus and Medline. The inclusion criteria encompassed studies assessing the efficacy of IVIG in aPL-positive patients with a high risk of miscarriage. Relevant articles were assessed for the quality and data were extracted for analysis. Two independent reviewers performed study selection, data extraction, and quality assessments. The risk of bias was evaluated according to the Cochrane risk of bias tool. All analyses were conducted using Review Manager 5.3. Results This systematic review included nine randomized controlled trials, with 366 aPL-positive women at high risk of miscarriage. These studies included in this review were randomized controlled trials. The primary outcome measures were successful pregnancy outcomes and live birth rates. The secondary outcomes included obstetric complications, and neonatal outcomes (such as birth weight and live-birth rate). The comparison between the intervention and control groups revealed no significant differences in terms of obstetric complications and neonatal outcomes. The group receiving IVIG treatment had a higher prevalence of preterm deliveries than controls (OR = 2.05, I2 = 46%, 95% CI [0.58–5.24]), but also exhibited a partial improvement in live birth rates (OR = 2.86, I2 = 52%, 95% CI [1.04–7.90]), because it reduced the number of miscarriages (OR = 0.35, I2 = 52%, 95% CI [0.13–0.96]). Conclusion Bas…
bibliographic citation: Yuan et al. (2024) Use of intravenous immunoglobulin in antiphospholipid antibody positive patients with high risk of miscarriage: a systematic review and meta-analysis. PeerJ 12:e18419 https://doi.org/10.7717/peerj.18419
date submitted: 2024-06-28
date accepted: 2024-10-07
issued: 2024-10-31
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Yuan
  given name: Xin
author list: Agent
  family name: Zhang
  given name: Wei
author list: Agent
  family name: Wang
  given name: Tong
author list: Agent
  family name: Jiang
  given name: Peng
author list: Agent
  family name: Wang
  given name: Zong-kui
author list: Agent
  family name: Li
  given name: Chang-qing
doi: 10.7717/peerj.18419
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-31
copyright: © 2024 Yuan et al.
attribution name: Yuan et al.

Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses
type: item
type: AcademicArticle
description: Introduction In Africa, healthcare professionals experienced various mental health problems during COVID-19. However, very little was done on the extensive evidence regarding mental disorders. The purpose of this umbrella review is to provide comprehensive data on the prevalence of anxiety, depression, stress, and insomnia among healthcare professionals during the COVID-19 pandemic in Africa. Materials and Methods Systematic searches of databases African Journals Online, MedRxiv, PubMed, and Google Scholar were used to identify studies from the occurrence of COVID-19 from December 2019 to March 2023 were included. To pool the gathered data for results with a 95% confidence interval (CI), DerSimonian-Laird random effects meta-analysis was used. For heterogeneity examination, I2 was used. The quality assessment was evaluated by using the Joanna Briggs Institute (JBI) critical appraisal checklist. Results A total of five studies reported the prevalence of depression, the pooled prevalence was 53.75% (95% CI [40.80–66.70], I2 = 63.6%, p = 0.027). In a total of four studies, the pooled prevalence of anxiety was 49.97% (95% CI [34.71–65.23], I2 = 71.26%, p = 0.014). From a total of two studies, the pooled prevalence of stress was 57.27% (95% CI [42.28–72.25], I2 = 58.9%, p = 0.119). From a total of four studies, the pooled prevalence of insomnia was 45.16% (95% CI [32.94–57.39], I2 = 50.8%, p = 0.107). Conclusions The COVID-19 pandemic highly affects the mental health of healthcare professionals in Africa. Stress, depression, anxiety, and insomnia symptoms were representing the most common based on evidences from existing meta-analyses. This evidence can help experts when executing specific interventions that address mental health problems among healthcare professionals during future public health crises.
format: application/pdf
format: text/html
creator: Aragaw Asfaw Hasen
creator: Ahmed Adem Mohammed
creator: Abubeker Alebachew Seid
subject: Evidence Based Medicine
subject: Global Health
subject: Nursing
subject: Mental Health
subject: COVID-19
description: doi:10.7717/peerj.18108
publisher: PeerJ Inc.
rights: © 2024 Hasen et al.
abstract: Introduction In Africa, healthcare professionals experienced various mental health problems during COVID-19. However, very little was done on the extensive evidence regarding mental disorders. The purpose of this umbrella review is to provide comprehensive data on the prevalence of anxiety, depression, stress, and insomnia among healthcare professionals during the COVID-19 pandemic in Africa. Materials and Methods Systematic searches of databases African Journals Online, MedRxiv, PubMed, and Google Scholar were used to identify studies from the occurrence of COVID-19 from December 2019 to March 2023 were included. To pool the gathered data for results with a 95% confidence interval (CI), DerSimonian-Laird random effects meta-analysis was used. For heterogeneity examination, I2 was used. The quality assessment was evaluated by using the Joanna Briggs Institute (JBI) critical appraisal checklist. Results A total of five studies reported the prevalence of depression, the pooled prevalence was 53.75% (95% CI [40.80–66.70], I2 = 63.6%, p = 0.027). In a total of four studies, the pooled prevalence of anxiety was 49.97% (95% CI [34.71–65.23], I2 = 71.26%, p = 0.014). From a total of two studies, the pooled prevalence of stress was 57.27% (95% CI [42.28–72.25], I2 = 58.9%, p = 0.119). From a total of four studies, the pooled prevalence of insomnia was 45.16% (95% CI [32.94–57.39], I2 = 50.8%, p = 0.107). Conclusions The COVID-19 pandemic highly affects the mental health of healthcare professionals in Africa. Stress, depression, anxiety, and insomnia symptoms were representing the most common based on evidences from existing meta-analyses. This evidence can help experts when executing specific interventions that address mental health problems among healthcare professionals during future public health crises.
bibliographic citation: Hasen et al. (2024) Prevalence of anxiety, depression, stress and insomnia among healthcare professionals during COVID-19 in Africa: umbrella review of existing meta-analyses. PeerJ 12:e18108 https://doi.org/10.7717/peerj.18108
date submitted: 2024-02-12
date accepted: 2024-08-27
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Hasen
  given name: Aragaw Asfaw
author list: Agent
  family name: Mohammed
  given name: Ahmed Adem
author list: Agent
  family name: Seid
  given name: Abubeker Alebachew
doi: 10.7717/peerj.18108
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Hasen et al.
attribution name: Hasen et al.

The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science
type: item
type: AcademicArticle
description: Argyreia Lour. is a speciose genus in the Convolvulaceae. However, the genus contains several problematic species complexes due to their morphological similarity. In this study, we aimed to resolve the Argyreia collinsiae complex, which consists of four similar operational taxonomic units (OTUs), i.e., A. collinsiae (Craib) Na Songkhla & Traiperm, A. dokmaihom Traiperm & Staples, A. versicolor (Kerr) Staples & Traiperm, and a peculiar OTU typically known as the large-bract morphotype of A. collinsiae. Following morphological comparison and phenetic analysis, all four OTUs were found to be distinct. However, the large-bract morphotype of A. collinsiae was confirmed to be more closely related to the original morphotype of A. collinsiae than to the other two species. Species distribution modeling (SDM) was then conducted for both morphotypes of A. collinsiae, revealing different geographical ranges of suitable habitat for each. In conclusion, the large-bract morphotype of A. collinsiae was described in this study as a new subspecies, A. collinsiae subsp. megabracteata Traiperm & Srisombat, subsp. nov., based on morphological differences and separate geographic range. We also provide here an identification key, description, detailed illustrations, distribution data, and ecological notes of the new subspecies. An updated description of A. versicolor and an assessment of its conservation status were also prepared since the original description was based solely on dried herbarium specimens and lacks key details.
format: application/pdf
format: text/html
creator: Poompat Srisombat
creator: Natthaphong Chitchak
creator: Pantamith Rattanakrajang
creator: Alyssa B. Stewart
creator: Paweena Traiperm
subject: Biodiversity
subject: Plant Science
subject: Taxonomy
description: doi:10.7717/peerj.18294
publisher: PeerJ Inc.
rights: © 2024 Srisombat et al.
abstract: Argyreia Lour. is a speciose genus in the Convolvulaceae. However, the genus contains several problematic species complexes due to their morphological similarity. In this study, we aimed to resolve the Argyreia collinsiae complex, which consists of four similar operational taxonomic units (OTUs), i.e., A. collinsiae (Craib) Na Songkhla & Traiperm, A. dokmaihom Traiperm & Staples, A. versicolor (Kerr) Staples & Traiperm, and a peculiar OTU typically known as the large-bract morphotype of A. collinsiae. Following morphological comparison and phenetic analysis, all four OTUs were found to be distinct. However, the large-bract morphotype of A. collinsiae was confirmed to be more closely related to the original morphotype of A. collinsiae than to the other two species. Species distribution modeling (SDM) was then conducted for both morphotypes of A. collinsiae, revealing different geographical ranges of suitable habitat for each. In conclusion, the large-bract morphotype of A. collinsiae was described in this study as a new subspecies, A. collinsiae subsp. megabracteata Traiperm & Srisombat, subsp. nov., based on morphological differences and separate geographic range. We also provide here an identification key, description, detailed illustrations, distribution data, and ecological notes of the new subspecies. An updated description of A. versicolor and an assessment of its conservation status were also prepared since the original description was based solely on dried herbarium specimens and lacks key details.
bibliographic citation: Srisombat et al. (2024) The Argyreia collinsiae species complex (Convolvulaceae): phenetic analysis and geographic distribution reveal subspecies new to science. PeerJ 12:e18294 https://doi.org/10.7717/peerj.18294
date submitted: 2024-04-16
date accepted: 2024-09-21
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Srisombat
  given name: Poompat
author list: Agent
  family name: Chitchak
  given name: Natthaphong
author list: Agent
  family name: Rattanakrajang
  given name: Pantamith
author list: Agent
  family name: Stewart
  given name: Alyssa B.
author list: Agent
  family name: Traiperm
  given name: Paweena
doi: 10.7717/peerj.18294
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Srisombat et al.
attribution name: Srisombat et al.

Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers
type: item
type: AcademicArticle
description: Objectives To investigate the effects of integrative neuromuscular training (INT) on the athletic performance of elite female boxers. Methods A before-and-after controlled experiment was conducted on 37 elite Chinese female boxers (Age: 26.00 ± 3.11 years). All included athletes have competed at the international level. The INT intervention was administered 11 times per week for 3 weeks. This training includes strength training, explosive training, core stability, agility exercises, high intensity intervals and sprint intervals. Basic physical fitness tests, including the deep squat and bench press one-repetition maximum (1RM), vertical long jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake; as well as specialized striking ability tests, including single-punch striking and 10-second, 30-second, and 3-minute continuous punching, were conducted before and after the intervention. Results Compared with pre-intervention baseline data, significant differences were found in the athletes’ post-intervention baseline physical fitness, including squat and beach press (1RM), vertical jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake (p < 0.05). Additionally, 10-second, 30-second, and 3-minute continuous punching were significantly different compared with pre-intervention (p < 0.05). However, no significant differences were found in single punch power (p > 0.05). Conclusion The 3-week INT can significantly improve the maximum strength, vertical explosive power, linear acceleration, agility, and continuous punching abilities of Chinese elite female boxers. The use of INT in physical training may enhance their athletic performance.
format: application/pdf
format: text/html
creator: Zhen Niu
creator: Zijing Huang
creator: Gan Zhao
creator: Chao Chen
subject: Kinesiology
subject: Biomechanics
subject: Sports Injury
subject: Sports Medicine
description: doi:10.7717/peerj.18311
publisher: PeerJ Inc.
rights: © 2024 Niu et al.
abstract: Objectives To investigate the effects of integrative neuromuscular training (INT) on the athletic performance of elite female boxers. Methods A before-and-after controlled experiment was conducted on 37 elite Chinese female boxers (Age: 26.00 ± 3.11 years). All included athletes have competed at the international level. The INT intervention was administered 11 times per week for 3 weeks. This training includes strength training, explosive training, core stability, agility exercises, high intensity intervals and sprint intervals. Basic physical fitness tests, including the deep squat and bench press one-repetition maximum (1RM), vertical long jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake; as well as specialized striking ability tests, including single-punch striking and 10-second, 30-second, and 3-minute continuous punching, were conducted before and after the intervention. Results Compared with pre-intervention baseline data, significant differences were found in the athletes’ post-intervention baseline physical fitness, including squat and beach press (1RM), vertical jump, 30 m sprint run, 400 m run, 3,000 m run, 1-minute hexagonal jump, and 3-minute double shake (p < 0.05). Additionally, 10-second, 30-second, and 3-minute continuous punching were significantly different compared with pre-intervention (p < 0.05). However, no significant differences were found in single punch power (p > 0.05). Conclusion The 3-week INT can significantly improve the maximum strength, vertical explosive power, linear acceleration, agility, and continuous punching abilities of Chinese elite female boxers. The use of INT in physical training may enhance their athletic performance.
bibliographic citation: Niu et al. (2024) Impact of three weeks of integrative neuromuscular training on the athletic performance of elite female boxers. PeerJ 12:e18311 https://doi.org/10.7717/peerj.18311
date submitted: 2024-06-17
date accepted: 2024-09-24
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Niu
  given name: Zhen
author list: Agent
  family name: Huang
  given name: Zijing
author list: Agent
  family name: Zhao
  given name: Gan
author list: Agent
  family name: Chen
  given name: Chao
doi: 10.7717/peerj.18311
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Niu et al.
attribution name: Niu et al.

Research progress on V delta 1+ T cells and their effect on pathogen infection
type: item
type: AcademicArticle
description: The ongoing high occurrence of harmful infectious diseases significantly threatens human health. Existing methods used to control such diseases primarily involve targeting the pathogens, usually neglecting the vital role of host factors in disease advancement. Gamma delta (γδ) T cells act as a bridge between innate and adaptive immunity, playing a crucial role in combating pathogen invasion. Among these γδT cell subsets, which are categorized based on T cell receptor delta variable expression patterns, V delta (δ) 1+ T cells possess unique recognition abilities and regulatory characteristics and actively engage in various immune responses. The differentiation, development, and immune reactivity of Vδ1+ T cells are closely associated with the initial and progressive stages of infectious diseases. This article provides an overview of the classification, distribution, differentiation, and development of Vδ1+ T cells and their mechanisms in combating pathogenic infections, offering new insights for disease diagnosis and treatment.
format: application/pdf
format: text/html
creator: Yuxia Li
creator: Yanfei Liu
creator: Xiaoxiao Bu
creator: Yuanyuan Qin
creator: Yanyan Zhang
subject: Cell Biology
subject: Microbiology
subject: Molecular Biology
subject: Immunology
subject: Infectious Diseases
description: doi:10.7717/peerj.18313
publisher: PeerJ Inc.
rights: © 2024 Li et al.
abstract: The ongoing high occurrence of harmful infectious diseases significantly threatens human health. Existing methods used to control such diseases primarily involve targeting the pathogens, usually neglecting the vital role of host factors in disease advancement. Gamma delta (γδ) T cells act as a bridge between innate and adaptive immunity, playing a crucial role in combating pathogen invasion. Among these γδT cell subsets, which are categorized based on T cell receptor delta variable expression patterns, V delta (δ) 1+ T cells possess unique recognition abilities and regulatory characteristics and actively engage in various immune responses. The differentiation, development, and immune reactivity of Vδ1+ T cells are closely associated with the initial and progressive stages of infectious diseases. This article provides an overview of the classification, distribution, differentiation, and development of Vδ1+ T cells and their mechanisms in combating pathogenic infections, offering new insights for disease diagnosis and treatment.
bibliographic citation: Li et al. (2024) Research progress on V delta 1+ T cells and their effect on pathogen infection. PeerJ 12:e18313 https://doi.org/10.7717/peerj.18313
date submitted: 2024-07-26
date accepted: 2024-09-24
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by-nc/4.0
author list: Agent
  family name: Li
  given name: Yuxia
author list: Agent
  family name: Liu
  given name: Yanfei
author list: Agent
  family name: Bu
  given name: Xiaoxiao
author list: Agent
  family name: Qin
  given name: Yuanyuan
author list: Agent
  family name: Zhang
  given name: Yanyan
doi: 10.7717/peerj.18313
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: © 2024 Li et al.
attribution name: Li et al.

Meta-analysis of the efficacy of the erector spinae plane block after spinal fusion surgery
type: item
type: AcademicArticle
description: Objective To investigate the efficacy of erector spinal plane block (ESPB) after spinal fusion surgery in this study. Methods The PubMed, Embase, Cochrane library, and Web of Science databases were searched with a search deadline of March 30, 2024, and Stata 15.0 was used to analyze the data from the included studies. Result Nine randomized controlled trials involving 663 patients were included. Meta-analysis showed that EPSB could reduce pain scores at 2h (standard mean difference (SMD) = −0.78, 95% CI [−1.38 to −0.19], GRADE: Moderate), 6 h (SMD = −0.81, 95% CI [−1.23 to −0.38], GRADE: Moderate), 12 h (SMD = −0.59, 95% CI [−1.05 to −0.13], GRADE: Moderate), 24 h (SMD = −0.54, 95% CI [−0.86 to −0.21], GRADE: Moderate), 48 h (SMD = −0.40, 95% CI [−0.75 to −0.05], GRADE: Moderate) after spinal fusion surgery, as well as the PCA (analgesia medication use) (SMD = −1.67, 95% CI [−2.67 to −0.67], GRADE: Moderate). However, EPSB had no effect on intraoperative blood loss (SMD = −0.28, 95% CI [−1.03 to 0.47], GRADE: Low) and length of hospital stay (SMD = −0.27, 95% CI [−0.60–0.06], GRADE: Low). Conclusion Combined with the current findings, EPSB may reduce pain scores in spinal fusion surgery, possibly reducing the use of postoperative analgesics. However, due to the limitations of the study, we need more high-quality, multi-center, large sample randomized controlled trials to merge.
format: application/pdf
format: text/html
creator: Yi He
creator: Heng Liu
creator: Peng Ma
creator: Jing Zhang
creator: Qiulian He
subject: Anesthesiology and Pain Management
subject: Epidemiology
description: doi:10.7717/peerj.18332
publisher: PeerJ Inc.
rights: © 2024 He et al.
abstract: Objective To investigate the efficacy of erector spinal plane block (ESPB) after spinal fusion surgery in this study. Methods The PubMed, Embase, Cochrane library, and Web of Science databases were searched with a search deadline of March 30, 2024, and Stata 15.0 was used to analyze the data from the included studies. Result Nine randomized controlled trials involving 663 patients were included. Meta-analysis showed that EPSB could reduce pain scores at 2h (standard mean difference (SMD) = −0.78, 95% CI [−1.38 to −0.19], GRADE: Moderate), 6 h (SMD = −0.81, 95% CI [−1.23 to −0.38], GRADE: Moderate), 12 h (SMD = −0.59, 95% CI [−1.05 to −0.13], GRADE: Moderate), 24 h (SMD = −0.54, 95% CI [−0.86 to −0.21], GRADE: Moderate), 48 h (SMD = −0.40, 95% CI [−0.75 to −0.05], GRADE: Moderate) after spinal fusion surgery, as well as the PCA (analgesia medication use) (SMD = −1.67, 95% CI [−2.67 to −0.67], GRADE: Moderate). However, EPSB had no effect on intraoperative blood loss (SMD = −0.28, 95% CI [−1.03 to 0.47], GRADE: Low) and length of hospital stay (SMD = −0.27, 95% CI [−0.60–0.06], GRADE: Low). Conclusion Combined with the current findings, EPSB may reduce pain scores in spinal fusion surgery, possibly reducing the use of postoperative analgesics. However, due to the limitations of the study, we need more high-quality, multi-center, large sample randomized controlled trials to merge.
bibliographic citation: He et al. (2024) Meta-analysis of the efficacy of the erector spinae plane block after spinal fusion surgery. PeerJ 12:e18332 https://doi.org/10.7717/peerj.18332
date submitted: 2024-05-02
date accepted: 2024-09-25
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: He
  given name: Yi
author list: Agent
  family name: Liu
  given name: Heng
author list: Agent
  family name: Ma
  given name: Peng
author list: Agent
  family name: Zhang
  given name: Jing
author list: Agent
  family name: He
  given name: Qiulian
doi: 10.7717/peerj.18332
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 He et al.
attribution name: He et al.

The critical need for child and youth perceptions of active living in India: capturing context complexity in rural and urban regions
type: item
type: AcademicArticle
description: Background The physical inactivity pandemic not only has a negative impact on the physical and mental health of children and youth, but it is also a key contributor to the non-communicable disease (NCD) burden, particularly among low- and middle-income countries. The widespread effects of climate change, ranging from extreme weather events to worsening air quality, are exacerbating the physical inactivity pandemic, highlighting the need to undertake holistic interventions to address environmental barriers while promoting physical activity. Despite the potential benefits of active school transportation (AST) on physical activity and the environment, no study has examined the intersection between perceptions of AST, environmental perceptions, and moderate-to-vigorous physical activity (MVPA) among children and youth in India from a child and youth perspective. Methods As a part of this cross-sectional, observational study, digital survey links were administered to 1,042 children and youth aged 5 to 17 (50.3% boys; 49.7% girls). Participants were recruited from 41 schools across 28 rural and urban regions in India. Children and youth provided information on various sociodemographic factors, perceptions of crime and air pollution, and peer support factors. MVPA data were collected using an adapted version of the IPAQ short-form questionnaire. The overall sample was stratified by age, gender, and location, resulting in a total of seven multiple linear regression models to assess the association between AST and MVPA. Results Children and youth who engaged in AST were associated with higher MVPA than those who did not engage in AST (β = 18.020, 95% CI [5.890 to 30.149], p = 0.004), after adjusting for age, gender, and location. In contrast, perceptions of high crime in the neighbourhood (β = − 21.921, CI [−36.195 to −7.647], p = 0.003) and perceptions of air pollution (β = − 12.472, CI [−23.797 to −1.147], p = 0.031) were associated with lower MVPA. Moreover, having active…
format: application/pdf
format: text/html
creator: Tarun Reddy Katapally
creator: Jamin Patel
creator: Anuradha Khadilkar
creator: Jasmin Bhawra
subject: Epidemiology
subject: Global Health
subject: Pediatrics
subject: Public Health
description: doi:10.7717/peerj.18350
publisher: PeerJ Inc.
rights: © 2024 Katapally et al.
abstract: Background The physical inactivity pandemic not only has a negative impact on the physical and mental health of children and youth, but it is also a key contributor to the non-communicable disease (NCD) burden, particularly among low- and middle-income countries. The widespread effects of climate change, ranging from extreme weather events to worsening air quality, are exacerbating the physical inactivity pandemic, highlighting the need to undertake holistic interventions to address environmental barriers while promoting physical activity. Despite the potential benefits of active school transportation (AST) on physical activity and the environment, no study has examined the intersection between perceptions of AST, environmental perceptions, and moderate-to-vigorous physical activity (MVPA) among children and youth in India from a child and youth perspective. Methods As a part of this cross-sectional, observational study, digital survey links were administered to 1,042 children and youth aged 5 to 17 (50.3% boys; 49.7% girls). Participants were recruited from 41 schools across 28 rural and urban regions in India. Children and youth provided information on various sociodemographic factors, perceptions of crime and air pollution, and peer support factors. MVPA data were collected using an adapted version of the IPAQ short-form questionnaire. The overall sample was stratified by age, gender, and location, resulting in a total of seven multiple linear regression models to assess the association between AST and MVPA. Results Children and youth who engaged in AST were associated with higher MVPA than those who did not engage in AST (β = 18.020, 95% CI [5.890 to 30.149], p = 0.004), after adjusting for age, gender, and location. In contrast, perceptions of high crime in the neighbourhood (β = − 21.921, CI [−36.195 to −7.647], p = 0.003) and perceptions of air pollution (β = − 12.472, CI [−23.797 to −1.147], p = 0.031) were associated with lower MVPA. Moreover, having active…
bibliographic citation: Katapally et al. (2024) The critical need for child and youth perceptions of active living in India: capturing context complexity in rural and urban regions. PeerJ 12:e18350 https://doi.org/10.7717/peerj.18350
date submitted: 2024-04-25
date accepted: 2024-09-27
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Katapally
  given name: Tarun Reddy
author list: Agent
  family name: Patel
  given name: Jamin
author list: Agent
  family name: Khadilkar
  given name: Anuradha
author list: Agent
  family name: Bhawra
  given name: Jasmin
doi: 10.7717/peerj.18350
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Katapally et al.
attribution name: Katapally et al.

Differences in cardiovascular disease mortality between northern and southern China under exposure to different temperatures: a systematic review
type: item
type: AcademicArticle
description: Background Due to differences in climate and other environmental factors, exposure to different temperatures in China has different effects on the relative risk (RR) of cardiovascular disease (CVD) mortality. It is therefore important to compare the effects of exposure to different temperatures on CVD mortality in different regions of China. Methods To compare these effects, we performed a meta-analysis of 21 studies identified by a search of the Web of Science and China National Knowledge Infrastructure databases from January 1, 2014 to January 1, 2024. We performed the Cochran Q test and I2 statistics test to evaluate heterogeneity and Egger’s test to evaluate publication bias. Results The pooled estimated size of the relationship between exposure to different temperatures and CVD mortality was 1.60 (95% confidence interval [CI]: [1.42–1.80]) for the extreme cold, 1.17 (95% CI [1.10–1.25]) for the extreme heat, and 1.16 (95% CI [1.10–1.24]) for extremely high diurnal temperature range (DTR). The Egger’s test showed potential publication bias in studies analyzing both the extreme cold and the extreme heat. Discussion Extreme cold, extreme heat, and extremely high DTR are associated with an increase in CVD mortality in China, with extreme cold having the most significant effect. Residents of northern regions are more susceptible to high temperatures, while residents of southern regions are more sensitive to low temperatures.
format: application/pdf
format: text/html
creator: Guangyu Zhai
creator: Ziqing Jiang
creator: Wenjuan Zhou
subject: Cardiology
subject: Statistics
subject: Environmental Health
description: doi:10.7717/peerj.18355
publisher: PeerJ Inc.
rights: © 2024 Zhai et al.
abstract: Background Due to differences in climate and other environmental factors, exposure to different temperatures in China has different effects on the relative risk (RR) of cardiovascular disease (CVD) mortality. It is therefore important to compare the effects of exposure to different temperatures on CVD mortality in different regions of China. Methods To compare these effects, we performed a meta-analysis of 21 studies identified by a search of the Web of Science and China National Knowledge Infrastructure databases from January 1, 2014 to January 1, 2024. We performed the Cochran Q test and I2 statistics test to evaluate heterogeneity and Egger’s test to evaluate publication bias. Results The pooled estimated size of the relationship between exposure to different temperatures and CVD mortality was 1.60 (95% confidence interval [CI]: [1.42–1.80]) for the extreme cold, 1.17 (95% CI [1.10–1.25]) for the extreme heat, and 1.16 (95% CI [1.10–1.24]) for extremely high diurnal temperature range (DTR). The Egger’s test showed potential publication bias in studies analyzing both the extreme cold and the extreme heat. Discussion Extreme cold, extreme heat, and extremely high DTR are associated with an increase in CVD mortality in China, with extreme cold having the most significant effect. Residents of northern regions are more susceptible to high temperatures, while residents of southern regions are more sensitive to low temperatures.
bibliographic citation: Zhai et al. (2024) Differences in cardiovascular disease mortality between northern and southern China under exposure to different temperatures: a systematic review. PeerJ 12:e18355 https://doi.org/10.7717/peerj.18355
date submitted: 2024-06-17
date accepted: 2024-09-27
issued: 2024-10-30
is part of: PeerJ
license: https://creativecommons.org/licenses/by/4.0/
author list: Agent
  family name: Zhai
  given name: Guangyu
author list: Agent
  family name: Jiang
  given name: Ziqing
author list: Agent
  family name: Zhou
  given name: Wenjuan
doi: 10.7717/peerj.18355
volume: 12
issn: 2167-8359
publication name: PeerJ
publication date: 2024-10-30
copyright: ©2024 Zhai et al.
attribution name: Zhai et al.

PeerJ
type: Periodical
uri: PeerJ
issn: 2167-8359