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The English language should be improved to ensure that an international audience can clearly understand your text. Some examples where the language could be improved include lines 292, 322 – the word ‘reliability’ makes comprehension difficult, suggest replacing with’dependency’.
Lines 91- Is it necessary the word ‘directly’ because the preparative HPLC is different from the above-mentioned quantitative HPLC.
Please check:
Lines 169- The signals for the H-15 of cryptotanshinone (4.884 ppm, t, 1H), 1H or 2H？
Lines 218- times of 17.2, 19.0, and 26.1 min, It doesn't match the coordinates in Fig. 2 (A2 and B2);
Lines 304- the doublets in 2b and 2f (left side) belonged to 305 tanshinone I, the doublet in 2f (right side) belongs to tanshinone IIA, there is a contradiction with the annotation of Figure 7
Lines 309- in 1c and 2f (right side) (Fig. 7) 1c or 1b?
Lines 315- tanshinone IIA calculated from the NMR spectra of the MCRS with five different concentrations, five or three?
no comment
no comment
The paper reported a novel strategy for the quantitative analysis of active components in traditional Chinese medicines, without individual reference standard. The proposed strategy was used for the quantitative analysis of cryptotanshinone, tanshinone I, and tanshinone IIA in Danshen Samples. I think it is worthy research work and has potentials in traditional Chinese medicines. However, there are still some details and issues as follows that need further clarification and discussion. Thus, I recommend the acceptance of this work after major revisions.
1.Accurate quantitative analysis of target analytes in complex matrices is very important, so, quantitative results of cryptotanshinone, tanshinone I, and tanshinone IIA in Danshen samples should be provided in the text.
2.The NMR spectra of complex mixtures often exhibit severe peak overlap, which can affect the accuracy of the quantity of analyte. The separation degree of the peaks in 1b, 2f (Figure 7) and 4a should be calculated.
3.The experiment process seems a little complicated, whether this will cause the loss of the target analyte?
4.The results of the proposed method should be verified by using individual reference standards and evaluated by using statistical methods.
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sss
The paper reported a novel strategy for the quantitative analysis of active components in traditional Chinese medicines, without individual reference standard. The proposed strategy was used for the quantitative analysis of cryptotanshinone, tanshinone I, and tanshinone IIA in Danshen Samples. I think it is worthy research work and has potentials in traditional Chinese medicines. However, there are still some details and issues as follows that need further clarification and discussion. Thus, I recommend the acceptance of this work after major revisions.
1.Accurate quantitative analysis of target analytes in complex matrices is very important, so, quantitative results of cryptotanshinone, tanshinone I, and tanshinone IIA in Danshen samples should be provided in the text.
2.The NMR spectra of complex mixtures often exhibit severe peak overlap, which can affect the accuracy of the quantity of analyte. The separation degree of the peaks in 1b, 2f (Figure 7) and 4a should be calculated.
3.The experiment process seems a little complicated, whether this will cause the loss of the target analyte?
4.The results of the proposed method should be verified by using individual reference standards and evaluated by using statistical methods.
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