Peer-reviewed Articles

23 downloads
260 views

Background Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal...

["Animal Behavior","Neuroscience","Pharmacology","Psychiatry and Psychology"]
doi:10.7717/peerj.4635
62 downloads
214 views

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids....

["Dermatology","Pharmacology","Medical Genetics"]
doi:10.7717/peerj.4637
68 downloads
435 views

Background The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient...

["Molecular Biology","Neuroscience","Anesthesiology and Pain Management","Oncology","Pharmacology"]
doi:10.7717/peerj.4622
65 downloads
380 views

Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important...

["Veterinary Medicine","Pharmacology","Translational Medicine"]
doi:10.7717/peerj.4387
109 downloads
330 views

Leaves of Passiflora suberosa L. (Family: Passifloraceae; common name: wild passion fruit, devil’s pumpkin) are used in Sri Lankan traditional medicine for treating diabetes. The present study investigated the in vivo ability of P. suberosa leaves to manage blood...

["Pharmacology"]
doi:10.7717/peerj.4389
86 downloads
731 views

There is growing interest in applying detailed mathematical models of the heart for ion-channel related cardiac toxicity prediction. However, a debate as to whether such complex models are required exists. Here an assessment in the predictive performance between...

["Mathematical Biology","Toxicology","Cardiology","Pharmacology"]
doi:10.7717/peerj.4352
122 downloads
571 views

Targeting tyrosinase is considered to be an effective way to control the production of melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin pigmentation, melanoma and neurodegenerative diseases. Herein, we report our results in identifying...

["Biochemistry","Pharmacology","Computational Science"]
doi:10.7717/peerj.4206
90 downloads
560 views

Previously, we revealed that several kampo medicines used for patients with excess and/or medium patterns (kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)) reduced prostaglandin (PG)E2 levels using LPS-treated human gingival fibroblasts...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7717/peerj.4120
98 downloads
700 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
155 downloads
1,188 views

Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7717/peerj.3993
2 citations
252 downloads
1,015 views

Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like...

["Immunology","Pharmacology"]
doi:10.7717/peerj.4053
290 downloads
747 views

Background Self-medication refers to the use of medicines to treat self-diagnosed diseases without consulting any healthcare professionals. Irrational drug use and self-medication have serious negative consequences both on health and economy. Therefore, the aim...

["Epidemiology","Pharmacology","Public Health"]
doi:10.7717/peerj.3990
1 citation
264 downloads
1,472 views

Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR “breakers”, namely direct antibacterial...

["Microbiology","Drugs and Devices","Global Health","Infectious Diseases","Pharmacology"]
doi:10.7717/peerj.3952
2 citations
231 downloads
769 views

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for...

["Biochemistry","Molecular Biology","Neuroscience","Neurology","Pharmacology"]
doi:10.7717/peerj.3933
145 downloads
692 views

Background The rapid increase in antibiotic resistance by various bacterial pathogens underlies the significance of developing new therapies and exploring different drug targets. A fraction of bacterial pathogens abbreviated as ESKAPE by the European Center for...

["Bioinformatics","Computational Biology","Microbiology","Pharmacology"]
doi:10.7717/peerj.3765

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