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4 downloads
41 views

Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes. It is believed that the three SNARE proteins assemble in steps along the dynamic...

["Biochemistry","Biophysics","Microbiology","Neuroscience"]
doi:10.7717/peerj.1065
7 downloads
53 views

The funnel-web spider Macrothele calpeiana is a charismatic Mygalomorph with a great interest in basic, applied and translational research. Nevertheless, current scarcity of genomic and transcriptomic data of this species clearly limits the research in this non-model...

["Evolutionary Studies","Genetics","Genomics","Zoology"]
doi:10.7717/peerj.1064
43 downloads
189 views

The extinct Stereogenyina turtles form a relatively diverse Podocnemididae lineage, with twelve described and phylogenetically positioned species. They are characterized by a wide geographic and temporal range, from the Eocene of Africa to the Pleistocene of Southeast...

["Paleontology","Taxonomy"]
doi:10.7717/peerj.1063
12 downloads
37 views

With on-going climate change, coral susceptibility to thermal stress constitutes a central concern in reefconservation. In the Persian Gulf, coral reefs are confronted with a high seasonal variability in water temperature, and both hot and cold extremes have been...

["Animal Behavior","Ecology","Marine Biology"]
doi:10.7717/peerj.1062
9 downloads
39 views

Clustering algorithms are often used to find groups relevant in a specific context; however, they are not informed about this context. We present a simple algorithm, HOODS, which identifies context-specific neighborhoods of entities from a similarity matrix and...

["Bioinformatics","Computational Biology","Computational Science"]
doi:10.7717/peerj.1057
5 downloads
20 views

The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro. We have previously shown that rimonabant (SR141716A) induces...

["Cell Biology","Neuroscience","Hematology","Immunology","Metabolic Sciences"]
doi:10.7717/peerj.1056
19 downloads
126 views

For tissues to carry out their functions, they rely on the right proteins to be present. Several high-throughput technologies have been used to map out which proteins are expressed in which tissues; however, the data have not previously been systematically compared...

["Computational Biology","Genomics"]
doi:10.7717/peerj.1054
11 downloads
68 views

Background. Documented trends in health-related risk behaviors among US adolescents have remained high over time. Studies indicate relationships among mutual friends are a major influence on adolescents’ risky behaviors. Social Network Analysis (SNA) can help understand...

["Global Health","Public Health"]
doi:10.7717/peerj.1052
5 downloads
31 views

Background. A good doctor–patient relationship is the centre stone of modern medicine. Patients are getting increasingly aware about exercising their autonomy and thus modern medicine cannot deliver all its advances to the patients if a good doctor–patient relationship...

["Evidence Based Medicine","Psychiatry and Psychology","Ethical Issues","Science and Medical Education"]
doi:10.7717/peerj.1050
5 downloads
75 views

FadD catalyses the first step in E. coli beta-oxidation, the activation of free fatty acids into acyl-CoA thioesters. This activation makes fatty acids competent for catabolism and reduction into derivatives like alcohols and alkanes. Alcohols and alkanes derived...

["Biochemistry","Bioengineering"]
doi:10.7717/peerj.1040
8 downloads
33 views

Patterns of dispersal and connectivity of the Caribbean gorgonian Antillogorgia elisabethae in The Bahamas were assessed in both adults and recently settled recruits from 13 sites using microsatellite loci. Adult populations along the Little Bahama Bank (LBB) exhibited...

["Biogeography","Ecology","Genetics","Marine Biology"]
doi:10.7717/peerj.1019
33 downloads
241 views

The production of recombinant proteins such as the fibroblast growth factors (FGFs) is the key to establishing their function in cell communication. The production of recombinant FGFs in E. coli is limited, however, due to expression and solubility problems. HaloTag...

["Biochemistry"]
doi:10.7717/peerj.1060
58 downloads
363 views

Understanding the role of predators in food webs can be challenging in highly diverse predator/prey systems composed of small cryptic species. DNA based dietary analysis can supplement predator removal experiments and provide high resolution for prey identification....

["Biodiversity","Ecology","Marine Biology","Molecular Biology","Zoology"]
doi:10.7717/peerj.1047
31 downloads
213 views

The relationship between clinical research and the pharmaceutical industry has placed clinical trials in jeopardy. According to the medical literature, more than 70% of clinical trials are industry-funded. Many of these trials remain unpublished or have methodological...

["Clinical Trials","Global Health","Public Health","Ethical Issues","Legal Issues"]
doi:10.7717/peerj.1015
43 downloads
208 views

The aim of our study was to examine the effects of 12-month therapy with recombinant growth hormone (rGH) on the blood antioxidant system in children with growth hormone deficiency (GHD). Total antioxidant capacity (TAC) of plasma was measured by FRAP (ferric reducing...

["Diabetes and Endocrinology","Pediatrics","Public Health"]
doi:10.7717/peerj.1055

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