Peer-reviewed Articles - Medicine

101 downloads
413 views

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated...

["Drugs and Devices","Ophthalmology"]
doi:10.7717/peerj.4549
54 downloads
858 views

Online stabilization of human standing posture utilizes multisensory afferences (e.g., vision). Whereas visual feedback of spontaneous postural sway can stabilize postural control especially when observers concentrate on their body and intend to minimize postural...

["Neuroscience","Kinesiology","Psychiatry and Psychology"]
doi:10.7717/peerj.4643
52 downloads
426 views

Background Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal...

["Animal Behavior","Neuroscience","Pharmacology","Psychiatry and Psychology"]
doi:10.7717/peerj.4635
55 downloads
292 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
387 downloads
1,997 views

Background Flexible pes planus (flat feet) in children is a common reason parents and caregivers seek health professionals consult and a frequent reason podiatrists prescribe foot orthoses. Yet no universal agreement exists on the diagnosis of this condition, or...

["Drugs and Devices","Kinesiology","Pediatrics"]
doi:10.7717/peerj.4667
68 downloads
417 views

In 2015, as part of the Prostate Cancer Foundation–Movember Foundation Reproducibility Initiative, we published a Registered Report (Shan et al., 2015) that described how we intended to replicate selected experiments from the paper “Androgen Receptor Splice Variants...

["Cell Biology","Oncology"]
doi:10.7717/peerj.4661
84 downloads
477 views

Malaria is a blood disease caused by the Plasmodium parasites transmitted through the bite of female Anopheles mosquito. Microscopists commonly examine thick and thin blood smears to diagnose disease and compute parasitemia. However, their accuracy depends on smear...

["Infectious Diseases","Computational Science","Data Mining and Machine Learning","Data Science"]
doi:10.7717/peerj.4568
80 downloads
271 views

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids....

["Dermatology","Pharmacology","Medical Genetics"]
doi:10.7717/peerj.4637
73 downloads
545 views

Background There is convincing evidence for the benefits of resistance training on vertical jump improvements, but little evidence to guide optimal training prescription. The inability to detect small between modality effects may partially reflect the use of ANOVA...

["Biophysics","Kinesiology"]
doi:10.7717/peerj.4620
146 downloads
559 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
109 downloads
652 views

Objective A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population....

["Clinical Trials","Oncology","Pediatrics","Psychiatry and Psychology"]
doi:10.7717/peerj.4570
132 downloads
466 views

Background Haemophilus parasuis is a common porcine respiratory pathogen that causes high rates of morbidity and mortality in farmed swine. We performed a molecular characterization of antimicrobial resistance genes harbored by H. parasuis from pig farms in China....

["Microbiology","Molecular Biology","Epidemiology","Statistics"]
doi:10.7717/peerj.4613
75 downloads
338 views

Background Converging evidence comparing barefoot (BF) and shod (SH) running highlights differences in foot-strike patterns and somatosensory feedback, among others. Anecdotal evidence from SH runners attempting BF running suggests a greater attentional demand...

["Anatomy and Physiology","Kinesiology"]
doi:10.7717/peerj.4605
49 downloads
258 views

Background The diagnosis of congenital heart defects is challenging, especially for what concerns conotruncal anomalies. Indeed, although the screening techniques of fetal cardiac anomalies have greatly improved, the detection rate of conotruncal anomalies still...

["Gynecology and Obstetrics","Radiology and Medical Imaging"]
doi:10.7717/peerj.4561
99 downloads
408 views

Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors. Early studies of serpins focused on their functions in haemostasis...

["Biochemistry","Microbiology","Parasitology","Immunology"]
doi:10.7717/peerj.4557

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