Peer-reviewed Articles - Medicine

27 downloads
107 views

Objective MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity...

["Cardiology","Geriatrics"]
doi:10.7717/peerj.5218
38 downloads
297 views

Objective Cannabis, like other substances, negatively affects health, inducing respiratory problems and mental and cognitive alterations. Memory and learning disorders, as well as executive dysfunctions, are also neuropsychological disorders associated to cannabis...

["Neuroscience","Cognitive Disorders","Public Health"]
doi:10.7717/peerj.5201
31 downloads
221 views

Background Solute-linked carrier 26 gene family 6 (SLC26A6), which is mainly expressed in intestines and kidneys, is a multifunctional anion transporter crucial in the transport of oxalate anions. This study aimed to investigate the role of kidney SLC26A6 in urolithiasis....

["Biotechnology","Molecular Biology","Urology"]
doi:10.7717/peerj.5192
40 downloads
711 views

Background Age and breed are considered the greatest risk factors for disease prevalence and mortality in companion dogs. Understanding the prevalence of diseases, in relation to age and breed, would support appropriate guidance for future health care strategies...

["Veterinary Medicine","Epidemiology","Evidence Based Medicine"]
doi:10.7717/peerj.5161
61 downloads
1,189 views

Background Mosquito repellents can be an effective method for personal protection against mosquito bites that are a nuisance and carry the risk of transmission of mosquito-borne pathogens like plasmodia, dengue virus, chikungunya virus, and Zika virus. A multitude...

["Animal Behavior","Entomology","Public Health"]
doi:10.7717/peerj.5151
31 downloads
247 views

HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in...

["Computational Biology","Immunology"]
doi:10.7717/peerj.5118
40 downloads
230 views

Honey has been shown to have a range of therapeutic effects in humans, with anti-inflammatory and anti-bacterial effects among those previously characterised. Here, we examine the possibility of New Zealand thyme, manuka and honeydew honeys, and their major sugar...

["Cell Biology","Toxicology","Oncology","Pharmacology"]
doi:10.7717/peerj.5115
56 downloads
369 views

Objective Gastric cancer (GC) is the fourth most common cause of cancer-related deaths in the world. In the current study, we aim to identify the hub genes and uncover the molecular mechanisms of GC. Methods The expression profiles of the genes and the miRNAs were...

["Bioinformatics","Gastroenterology and Hepatology","Data Mining and Machine Learning"]
doi:10.7717/peerj.5180
45 downloads
323 views

Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoof-horn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship with pro-inflammatory...

["Agricultural Science","Veterinary Medicine","Immunology","Histology"]
doi:10.7717/peerj.5097
76 downloads
343 views

Background Obesity-induced glucose metabolism disorder is associated with chronic, low-grade, systemic inflammation and is considered a risk factor for diabetes and metabolic syndrome. Resveratrol (RES), a natural anti-inflammatory compound, is observed to improve...

["Diabetes and Endocrinology","Immunology","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.5173
57 downloads
234 views

The aim of this study was to determine the role of the perlecan (Hspg2) heparan sulphate (HS) side chains on cell and matrix homeostasis in tail and Achilles tendons in 3 and 12 week old Hspg2 exon 3 null HS deficient (Hspg2Δ3 − ∕Δ3 −) and C57 BL/6 Wild Type (WT)...

["Biochemistry","Anatomy and Physiology"]
doi:10.7717/peerj.5120
58 downloads
202 views

To investigate how additional visual feedback (VFB) affects postural stability we compared 20-sec center-of-pressure (COP) recordings in two conditions: without and with the VFB. Seven healthy adult subjects performed 10 trials lasting 20 seconds in each condition....

["Bioengineering","Neuroscience","Kinesiology"]
doi:10.7717/peerj.5101
72 downloads
579 views

Background Obesity is a key public health problem. The advancement of gut microbiota research sheds new light on this field. This article aims to present the research trends in global intestinal microbiota studies within the domain of obesity research. Methods...

["Evidence Based Medicine","Gastroenterology and Hepatology","Global Health","Data Mining and Machine Learning","Data Science"]
doi:10.7717/peerj.5091
56 downloads
2,055 views

Background The factors influencing pubertal timing have gained much attention due to a secular trend toward earlier pubertal onset in many countries. However, no studies have investigated the association between the Great earthquake and early puberty. We aimed...

["Epidemiology","Pediatrics","Public Health"]
doi:10.7717/peerj.5085
29 downloads
203 views

Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are the most commonly prescribed antihypertensive medications in higher-risk surgical patients. However, there is no clinical consensus on their use in the perioperative...

["Anesthesiology and Pain Management","Surgery and Surgical Specialties","Ethical Issues"]
doi:10.7717/peerj.5061

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