Peer-reviewed Articles - Medicine

206 downloads
201 views

Triple-negative breast cancer (TNBC) is a particular subtype of breast malignant tumor with poorer prognosis than other molecular subtypes. Previous studies have demonstrated that some abnormal expression of non-coding RNAs including microRNAs (miRNAs) and long...

["Bioinformatics","Genomics","Oncology"]
doi:10.7717/peerj.7522
135 downloads
127 views

Background The pro-tumoral action of the cluster of differentiation 147 (CD147), which is associated with the chemotherapy resistance of lung adenocarcinoma, is partly due to accelerated tumor cell glycolysis. 18F-fluorodeoxyglucose positron emission tomography...

["Oncology","Radiology and Medical Imaging","Respiratory Medicine"]
doi:10.7717/peerj.7635
147 downloads
194 views

Background Injection of adipose-derived stem cells (ASCs) is a promising treatment for facial contour deformities. However, its treatment mechanisms remain largely unknown. The study aimed to explain the molecular mechanisms of adipogenic differentiation from ASCs...

["Bioinformatics","Computational Biology","Genomics","Surgery and Surgical Specialties"]
doi:10.7717/peerj.7544
206 downloads
255 views

Hepatocellular carcinoma (HCC) is a common yet deadly form of malignant cancer. However, the specific mechanisms involved in HCC diagnosis have not yet fully elucidated. Herein, we screened four publically available Gene Expression Omnibus (GEO) expression profiles...

["Bioinformatics","Gastroenterology and Hepatology"]
doi:10.7717/peerj.7619
133 downloads
164 views

Background Alzheimer’s disease (AD) is the primary cause of dementia in the elderly. The imbalance between production and clearance of amyloid β (Aβ) is a very early, often initiating factor in AD. Dendrobium nobile Lindl. alkaloids (DNLA) extracted from a Chinese...

["Neuroscience","Drugs and Devices","Evidence Based Medicine","Pharmacology"]
doi:10.7717/peerj.7627
111 downloads
200 views

Background The total number of nephrons has been measured mainly from post-mortem studies and only in selected populations. Data from living subjects are scanty, and direct comparisons among different glomerular diseases are lacking. The present work exploits modern...

["Nephrology","Pathology"]
doi:10.7717/peerj.7640
189 downloads
216 views

Objective This study aims to identify effective gene networks and biomarkers to predict response and prognosis for HER2-negative breast cancer patients who received sequential taxane-anthracycline neoadjuvant chemotherapy. Materials and Methods Transcriptome data...

["Cell Biology","Genetics","Oncology","Women\u2019s Health"]
doi:10.7717/peerj.7515
136 downloads
221 views

Objective Aloperine (ALO), an alkaloid isolated from the leaves of Sophora alopecuroides, has been suggested to exhibit anti-inflammatory and anti-tumor properties and is traditionally used to treat various human diseases, including cancer. However, limited information...

["Molecular Biology","Oncology","Pharmacology"]
doi:10.7717/peerj.7652
209 downloads
317 views

Osteoarthritis (OA) is the most common motor system disease in aging people, characterized by matrix degradation, chondrocyte death, and osteophyte formation. OA etiology is unclear, but long noncoding RNAs (lncRNAs) that participate in numerous pathological and...

["Genetics","Genomics","Orthopedics","Ethical Issues"]
doi:10.7717/peerj.7491
116 downloads
252 views

Cognitive impairment often involves the decreased expression or hypofunction of alpha 7-type nicotinic acetylcholine receptors (α7 nAChRs). Agonists or positive allosteric modulators (PAMs) of α7 nAChRs are known to be potential treatments for dementias, different...

["Biophysics","Neuroscience","Pharmacology"]
doi:10.7717/peerj.7542
91 downloads
244 views

Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional...

["Microbiology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.7224
86 downloads
177 views

Background It is known that adolescent idiopathic scoliosis (AIS) is often accompanied by balance deficits. This reciprocal relationship must be taken into account when prescribing new therapeutic modalities because these may differently affect postural control,...

["Bioengineering","Kinesiology","Pediatrics"]
doi:10.7717/peerj.7513
133 downloads
320 views

Objectives To map publication trends and explore research hotspots of retinal vein occlusion (RVO) study. Methods Based on Web of Science Core Collection (WoSCC), a bibliometric analysis was carried out. The knowledge map was constructed by VOSviewer v.1.6.10 to...

["Bioinformatics","Epidemiology","Ophthalmology","Data Mining and Machine Learning","Data Science"]
doi:10.7717/peerj.7603
80 downloads
293 views

Testosterone plays a key role in shaping human social behavior. Recent findings have linked testosterone to altruistic behavior in economic decision tasks depending on group membership and intergroup competition. The preferential treatment of ingroup members, while...

["Anthropology","Andrology","Psychiatry and Psychology"]
doi:10.7717/peerj.7537
54 downloads
160 views

Background The relapse rate of alcohol dependence (AD) after detoxification is high, but few studies have investigated the clinical predictors of relapse after hospitalized detoxification in real-world clinical practice, especially among Chinese patients. Methods...

["Psychiatry and Psychology"]
doi:10.7717/peerj.7547

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