Peer-reviewed Articles

7 citations
770 downloads
3,345 views

Drug repositioning methods attempt to identify novel therapeutic indications for marketed drugs. Strategies include the use of side-effects to assign new disease indications, based on the premise that both therapeutic effects and side-effects are measurable physiological...

["Bioinformatics","Data Mining and Machine Learning","Computational Biology","Social Computing"]
doi:10.7717/peerj-cs.46
1 citation
167 downloads
825 views

Recent additions to the repertoire of gene expression regulatory mechanisms are polyadenylate (polyA) tracks encoding for poly-lysine runs in protein sequences. Such tracks stall the translation apparatus and induce frameshifting independently of the effects of...

["Bioinformatics","Databases"]
doi:10.7717/peerj-cs.45
3 citations
239 downloads
1,310 views

The information expressed in humanities datasets is inextricably tied to a wider discursive environment that is irreducible to complete formal representation. Humanities scholars must wrestle with this fact when they attempt to publish or consume structured data....

["Digital Libraries","World Wide Web and Web Science"]
doi:10.7717/peerj-cs.44
1 citation
637 downloads
1,874 views

Sandboxes are increasingly important building materials for secure software systems. In recognition of their potential to improve the security posture of many systems at various points in the development lifecycle, researchers have spent the last several decades...

["Security and Privacy","Operating Systems","Software Engineering"]
doi:10.7717/peerj-cs.43
2 citations
562 downloads
1,522 views

One of the main motivations behind social network analysis is the quest for understanding opinion formation and diffusion. Previous models have limitations, as they typically assume opinion interaction mechanisms based on thresholds which are either fixed or evolve...

["Network Science and Online Social Networks","Scientific Computing and Simulation","Social Computing"]
doi:10.7717/peerj-cs.42
4 citations
632 downloads
1,460 views

Academic publication metadata can be used to analyze the collaboration, productivity and hot topic trends of a research community. In this paper, we study a specific group of authors, namely the top active authors. They are defined as the top 1% authors with uninterrupted...

["Data Mining and Machine Learning","Data Science","Digital Libraries","Network Science and Online Social Networks","Social Computing"]
doi:10.7717/peerj-cs.41
374 downloads
1,103 views

We describe and experimentally validate a question-asking framework for machine-learned linguistic knowledge about human emotions. Using the Socratic method as a theoretical inspiration, we develop an experimental method and computational model for computers to...

["Agents and Multi-Agent Systems","Artificial Intelligence","Computational Linguistics","Data Mining and Machine Learning","Natural Language and Speech"]
doi:10.7717/peerj-cs.40
150 downloads
1,109 views

Common tasks in document analysis, such as binarization, line extraction etc., are still considered difficult for highly degraded text documents. Having reliable fundamental information regarding the characters of the document, such as the distribution of character...

["Computer Vision","Digital Libraries"]
doi:10.7717/peerj-cs.39
7 citations
751 downloads
2,428 views

Motivation. Finding relevant scientific literature is one of the essential tasks researchers are facing on a daily basis. Digital libraries and web information retrieval techniques provide rapid access to a vast amount of scientific literature. However, no further...

["Artificial Intelligence","Digital Libraries","Natural Language and Speech"]
doi:10.7717/peerj-cs.37
296 downloads
1,253 views

Reducing the energy footprint of data centers continues to receive significant attention due to both its financial and environmental impact. There are numerous methods that limit the impact of both factors, such as expanding the use of renewable energy or participating...

["Distributed and Parallel Computing","Multimedia","Operating Systems"]
doi:10.7717/peerj-cs.34
10 citations
1,287 downloads
14,530 views

Social media have become a prevalent channel to access information, spread ideas, and influence opinions. However, it has been suggested that social and algorithmic filtering may cause exposure to less diverse points of view. Here we quantitatively measure this...

["Network Science and Online Social Networks","Social Computing","World Wide Web and Web Science"]
doi:10.7717/peerj-cs.38
3 citations
1,045 downloads
1,734 views

Background. Regular physical activity can substantially improve the physical wellbeing of older adults, preventing several chronic diseases and increasing cognitive performance and mood. However, research has shown that older adults are the most sedentary segment...

["Human\u2013Computer Interaction","Emerging Technologies","Mobile and Ubiquitous Computing","Network Science and Online Social Networks"]
doi:10.7717/peerj-cs.30
4 citations
305 downloads
1,964 views

Agent-based modeling (ABM) is a bottom-up modeling approach, where each entity of the system being modeled is uniquely represented as an independent decision-making agent. ABMs are very sensitive to implementation details. Thus, it is very easy to inadvertently...

["Agents and Multi-Agent Systems","Scientific Computing and Simulation","Theory and Formal Methods"]
doi:10.7717/peerj-cs.36
219 downloads
883 views

We propose a robust method to convert triangulated surface data into polynomial volume data. Such polynomial representations are required for high-order partial differential solvers, as low-order surface representations would diminish the accuracy of their solution....

["Computer Aided Design","Scientific Computing and Simulation"]
doi:10.7717/peerj-cs.35
252 downloads
981 views

CRISPR/Cas9 is emerging as one of the most-used methods of genome modification in organisms ranging from bacteria to human cells. However, the efficiency of editing varies tremendously site-to-site. A recent report identified a novel motif, called the 3′GG motif,...

["Bioinformatics","Computational Biology","Data Science","Databases"]
doi:10.7717/peerj-cs.33

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