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2025
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway
Phytomedicine
2025
Can Focused Ultrasound Overcome the Failure of Chemotherapy in Treating Pediatric Diffuse Intrinsic Pontine Glioma Due to a Blood–Brain Barrier Obstacle?
Pharmaceuticals
2025
Mitophagy in Health and Disease
2025
Mitochondrial unfolded protein response (UPR mt ) as novel therapeutic targets for neurological disorders
Journal of Cerebral Blood Flow & Metabolism
2025
SRC is a potential target of Arctigenin in treating triple-negative breast cancer: based on machine learning algorithms, molecular modeling and in Vitro test
Frontiers in Molecular Biosciences
2025
Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression
Cell Communication and Signaling
2025
Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease
International Immunopharmacology
2025
Enhancing Sonodynamic Therapy in Prostate Cancer: Cavitation-Induced Cytotoxicity and Mitochondrial Unfolded Protein Response Disruption
Cell Biochemistry and Biophysics
2024
Mitochondrial unfolded protein response (UPRmt): what we know thus far
Frontiers in Cell and Developmental Biology
2024
A bird’s eye view of mitochondrial unfolded protein response in cancer: mechanisms, progression and further applications
Cell Death & Disease
2024
ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells
Neoplasia
2023
The role of protein kinase R in placental inflammation, mtUPR and apoptosis
Placenta
2023
Targeting Mitochondria with ClpP Agonists as a Novel Therapeutic Opportunity in Breast Cancer
Cancers
2023
ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
eLife
2023
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
European Journal of Medicinal Chemistry
2023
Mitochondrial quality control proteases and their modulation for cancer therapy
Medicinal Research Reviews
2023
ONC201 Suppresses Neuroblastoma Growth by Interrupting Mitochondrial Function and Reactivating Nuclear ATRX Expression While Decreasing MYCN
International Journal of Molecular Sciences
2023
mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases
International Journal of Molecular Sciences
2023
Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases
Biomolecules
2023
The Enzymes
2023
The Journey of Mitochondrial Protein Import and the Roadmap to Follow
International Journal of Molecular Sciences
2022
Role of Mitochondrial Stress Response in Cancer Progression
Cells
2022
Substrates and interactors of the ClpP protease in the mitochondria
Current Opinion in Chemical Biology
2022
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Pharmacology Research & Perspectives
2022
Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
Journal of Biological Chemistry
2022
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges
Cell & Bioscience
2022
Autophagy‐independent mitochondrial quality control: Mechanisms and disease associations
MedComm – Future Medicine
2022
Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo
Journal of Medicinal Chemistry
2022
Mitochondrial matrix proteases: quality control and beyond
The FEBS Journal
2022
Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src
Phytomedicine
2022
The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
Journal of Hematology & Oncology
2021
Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy
Frontiers in Oncology
2021
Genetic Variants of CLPP and M1AP Are Associated With Risk of Non-Small Cell Lung Cancer
Frontiers in Oncology
2021
Failure to Guard: Mitochondrial Protein Quality Control in Cancer
International Journal of Molecular Sciences
2021
Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction
Drug Discovery Today
2021
Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer
Diagnostics
2021
Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer
International Journal of Molecular Sciences
2021
Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets
Cancers
2020
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Cell Death & Disease
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