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2024
Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease
npj Parkinson's Disease
2024
Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in model
Scientific Reports
2023
Cheminformatics and Bioinformatics at the Interface with Systems Biology
2023
Leucine-rich repeat kinase 2 at a glance
Journal of Cell Science
2022
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
The American Journal of Human Genetics
2021
LRRK2 signaling in neurodegeneration: two decades of progress
Essays in Biochemistry
2021
Advances in protein-protein interaction network analysis for Parkinson's disease
Neurobiology of Disease
2021
In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung
Brain Research
2020
Changing the Nature of Quantitative Biology Education: Data Science as a Driver
Bulletin of Mathematical Biology
2020
LRRK2 Phosphorylation, More Than an Epiphenomenon
Frontiers in Neuroscience
2020
Guilt-by-Association – Functional Insights Gained From Studying the LRRK2 Interactome
Frontiers in Neuroscience
2020
Towards a unified open access dataset of molecular interactions
Nature Communications
2020
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Neurobiology of Disease
2020
Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease
Frontiers in Aging Neuroscience
2020
The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
Cell Reports
2020
Comprehensive Genomic Analysis Reveals the Prognostic Role of LRRK2 Copy-Number Variations in Human Malignancies
Genes
2020
Leucine‐rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease
Journal of Neurochemistry
2020
The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant
Scientific Reports
2020
Precision medicine in Parkinson’s disease: emerging treatments for genetic Parkinson’s disease
Journal of Neurology
2020
Vesicular Dysfunction and the Pathogenesis of Parkinson’s Disease: Clues From Genetic Studies
Frontiers in Neuroscience
2019
LRRK2 and membrane trafficking: nexus of Parkinson's disease
BMB Reports
2019
Leucine rich repeat kinase 2: a paradigm for pleiotropy
The Journal of Physiology
2019
The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2019
Alzheimer’s Disease
2018
Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins
PROTEOMICS
2018
The role of LRRK2 in cytoskeletal dynamics
Biochemical Society Transactions
2018
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
The EMBO Journal
2018
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
Briefings in Bioinformatics
2018
The LRRK2 signalling system
Cell and Tissue Research
2017
The LRRK2–macroautophagy axis and its relevance to Parkinson's disease
Biochemical Society Transactions
2017
Leucine‐rich repeat kinase 2 and Parkinson's disease
PROTEOMICS
2017
68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment
Frontiers in Aging Neuroscience
2017
Leucine Rich Repeat Kinase 2: beyond Parkinson’s and beyond kinase inhibitors
Expert Opinion on Therapeutic Targets
2017
LRRK2: from kinase to GTPase to microtubules and back
Biochemical Society Transactions
2017
Bioinformatics analysis of the proteins interacting with LASP-1 and their association with HBV-related hepatocellular carcinoma
Scientific Reports
2016
First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein
Biochemical Society Transactions
2016
Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson’s disease
Proceedings of the National Academy of Sciences
2016
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
Scientific Reports
2016
LRRK2 at the interface of autophagosomes, endosomes and lysosomes
Molecular Neurodegeneration
2016
Exploring the Effects of Genetic Variants on Clinical Profiles of Parkinson’s Disease Assessed by the Unified Parkinson’s Disease Rating Scale and the Hoehn–Yahr Stage
PLOS ONE
2016
Using the Gene Ontology to Annotate Key Players in Parkinson’s Disease
Neuroinformatics
2015
Cellular processes associated with LRRK2 function and dysfunction
The FEBS Journal
2015
LRRK2 Pathways Leading to Neurodegeneration
Current Neurology and Neuroscience Reports
2015
Parkinson’s disease: From human genetics to clinical trials
Science Translational Medicine
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