TY - JOUR UR - https://doi.org/10.7717/peerj.7237 DO - 10.7717/peerj.7237 TI - Nomogram to predict the prognosis of parotid gland mucoepidermoid carcinoma: a population-based study of 1306 cases AU - Sun,Jian AU - Sun,Yang AU - Yang,Fei AU - Zhou,Qianrong AU - Liu,Wenjuan AU - Cheng,Yong AU - Wu,Xingwen AU - Chen,Tinglan AU - Li,Ruixue AU - Huang,Borui AU - Att,Wael AU - Yu,Youcheng AU - Bi,Wei A2 - Palazón-Bru,Antonio DA - 2019/07/01 PY - 2019 KW - Mucoepidermoid carcinoma KW - Parotid gland KW - Prognosis KW - Nomogram KW - SEER database AB - Background Mucoepidermoid carcinoma (MEC) is a common cancer in the oral salivary gland malignancy, which mainly occurs in the parotid gland. The aim of this study is to identify independent prognostic factors and establish a nomogram model for parotid gland mucoepidermoid carcinoma (P-MEC) patients using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. Method Patients with P-MEC were selected from between 2004 and 2015. The overall survival (OS) and cancer-specific survival (CSS) rates were estimated using the Kaplan-Meier method with the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors. Results A total of 1,306 patients with P-MEC were enrolled. Age, grade, T stage, N stage, M stage, chemotherapy, and surgery type were independent prognostic factors for OS and CSS. A nomogram for OS was formulated based on these independent prognostic factors and validated using an internal bootstrap resampling approach, which showed that the nomogram exhibited a sufficient level of discrimination according to the C-index (0.877, 95% CI [0.855–0.898]). Conclusion Several prognostic factors for P-MEC were identified. The nomogram developed in this study accurately predicted the 5- and 10-year OS rates of American patients with P-MEC based on individual characteristics. Risk stratification using the survival nomogram can optimize individual therapies and follow-up. VL - 7 SP - e7237 T2 - PeerJ JO - PeerJ J2 - PeerJ SN - 2167-8359 ER -