Review History

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  • The initial submission of this article was received on November 4th, 2014 and was peer-reviewed by the Academic Editor.
  • The Academic Editor made their initial decision on November 21st, 2014.
  • The first revision was submitted on November 28th, 2014 and was reviewed by the Academic Editor.
  • The article was Accepted by the Academic Editor on November 30th, 2014.

Version 0.2 (accepted)

· · Academic Editor


Thank you for addressing the concerns raised in my previous comments.

I am pleased to let you know that your manuscript is now accepted for publication in PeerJ. Congratulations!

Philip M Jones, MD, MSc (Clin Trials), FRCPC


Version 0.1 (original submission)

· · Academic Editor

Minor Revisions

After rejection at eLife, the authors elected to submit to PeerJ. I reviewed the eLife Reviewers' comments, the responses to these comments by the authors, and after this review I did not deem it necessary to send out for further peer review. The authors did a fantastic job at responding to the previous Reviewers' comments and criticisms, including some re-analysis of their data.

This paper is an interesting and provocative epidemiological investigation using data recently made available to the public. The authors investigated the putative carcinogenic effect of higher partial pressures of oxygen (lower elevations) on the incidence of lung cancer (as well as other cancers). The authors found a potential link of higher exposure to oxygen being positively correlated to lung cancer incidence. They postulate that people living at higher elevations, due to a lower overall oxygen exposure, may have a lower incidence of lung cancer.

Although any observational study is subject to residual confounding from unmeasured or unknown confounders, the authors have done a very good job with their analysis to assess this potential from multiple angles. The results were all consistent and now they provide a new topic to investigate using individual-level data in the future to strengthen support for what is, at this time, an interesting but uncertain association.

I would like to congratulate the authors on performing this work to such a high standard.

I have made numerous comments in the attached file (to be emailed to you seperately). I would appreciate it if the authors would go through this file and respond to each of the concerns raised. I do not think any of the concerns will be difficult to deal with.

This paper will be published in PeerJ assuming a satisfactory response to the issues raised.

Philip M Jones, MD MSc (Clinical Trials) FRCPC

Associate Professor
Department of Anesthesia & Perioperative Medicine
Program in Critical Care, Department of Medicine
Department of Epidemiology & Biostatistics
University of Western Ontario / London Health Sciences Centre

External reviews were received for this submission. These reviews were used by the Editor when they made their decision, and can be downloaded below.

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