To increase transparency, PeerJ operates a system of 'optional signed reviews and history'. This takes two forms: (1) peer reviewers are encouraged, but not required, to provide their names (if they do so, then their profile page records the articles they have reviewed), and (2) authors are given the option of reproducing their entire peer review history alongside their published article (in which case the complete peer review process is provided, including revisions, rebuttal letters and editor decision letters).
I read your revised manuscript. I recognize that you have appropriately revised the manuscript according to the reviewers' comments. Therefore, I have no more comments on your revised manuscript, which is accepted for publication in PeerJ.
Thank you very much for your submission to PeerJ.
Reviewer 1 recommends to accept your manuscript in the current form for publication in PeerJ, but Reviewer 2 recommends some revision before acceptance for publication of your manuscript in PeerJ.
I hope that you could revise your manuscript according to the Reviewer's comments by providing additional experimental results or some discussion resolving points raised by Reviewer 2.
I think that it is a excellent article.
The authors demonstrated that all rice koji have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice koji consumed. This study include an interesting finding, hover, they should revise it according to the following suggestions.
1) To clarify the effects of these extract on hepatic fatty acid synthesis, the authors should measure the expression of mRNA levels of ACD, acyl-coenzyme A dehydrogenase, CPT II, carnitine palmitoyl transferase II, ACC, acetyl-CoA carboxylase, ACL, ATP citrate lyase in addition to FAS, ACACbeta, and PPARalpha.
2) The authors should investigate the GLUT4 expression on muscle of in vivo model, and should investigate the effect of these extracts on the expression of GLUT4.
The authors should carefully evaluate the effects of extracts on myotube cells, and also should confirm these findings using samples from in vivo model.
They should revise it according to the following suggestions.
All text and materials provided via this peer-review history page are made available under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.