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2024
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
2023
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
2023
Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology
eLife
2023
Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology
eLife
2023
Quantitative Systems Pharmacology and Machine Learning: A Match Made in Heaven or Hell?
Journal of Pharmacology and Experimental Therapeutics
2022
Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective
Journal of Pharmacological and Toxicological Methods
2022
A Quantitative Systems Pharmacology Perspective on the Importance of Parameter Identifiability
Bulletin of Mathematical Biology
2021
Assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine using the CiPA concept
European Journal of Pharmacology
2020
Modelling and Simulation for Preclinical Cardiac Safety Assessment of Drugs with Human iPSC-Derived Cardiomyocytes
Jahresbericht der Deutschen Mathematiker-Vereinigung
2020
Small Models for Big Data
Clinical Pharmacology & Therapeutics
2020
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
Clinical Pharmacology & Therapeutics
2020
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model
Journal of Pharmacological and Toxicological Methods
2020
Identification of Drug-Induced Multichannel Block and Proarrhythmic Risk in Humans Using Continuous T Vector Velocity Effect Profiles Derived From Surface Electrocardiograms
Frontiers in Physiology
2019
Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment
Frontiers in Pharmacology
2019
Response to “CiPA's Complexity Bias”
Clinical Pharmacology & Therapeutics
2019
Usefulness of Bnet, a Simple Linear Metric in Discerning Torsades De Pointes Risks in 28 CiPA Drugs
Frontiers in Pharmacology
2019
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative
Clinical Pharmacology & Therapeutics
2019
Comprehensive In Vitro Proarrhythmic Assay Complexity Bias
Clinical Pharmacology & Therapeutics
2019
Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp
Journal of Pharmacological and Toxicological Methods
2019
Quantitative Systems Pharmacology Models for a New International Cardiac Safety Regulatory Paradigm: An Overview of the Comprehensive In Vitro Proarrhythmia Assay In Silico Modeling Approach
CPT: Pharmacometrics & Systems Pharmacology
2018
CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion
Journal of Pharmacological and Toxicological Methods
2018
Five years of the CiPA project (2013–2018): what did we learn?
Translational and Clinical Pharmacology
2018
Benchmarking QSP Models Against Simple Models: A Path to Improved Comprehension and Predictive Performance
CPT: Pharmacometrics & Systems Pharmacology
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