Review History


To increase transparency, PeerJ operates a system of 'optional signed reviews and history'. This takes two forms: (1) peer reviewers are encouraged, but not required, to provide their names (if they do so, then their profile page records the articles they have reviewed), and (2) authors are given the option of reproducing their entire peer review history alongside their published article (in which case the complete peer review process is provided, including revisions, rebuttal letters and editor decision letters).

New to public reviews? Learn more about optional signed reviews and how to write a better rebuttal letter.

Summary

  • The initial submission of this article was received on March 28th, 2014 and was peer-reviewed by 2 reviewers and the Academic Editor.
  • The article was Accepted by the Academic Editor on May 7th, 2014.

Version 0.1 (accepted)

· · Academic Editor

Accept

The manuscript can be accepted in the actual form

·

Basic reporting

The manuscript by Rosales-Calderon et al. is a clearly written solid report which is appropriate for publication in its present form.

The authors demonstrate that protein aggregation combined with non-productive biomass binding is an important feature of cellulase hydrolysis. This finding has practical impacts regarding the use of stabilizers. Their results also suggest that enzyme recycling approaches may not be feasible, since the enzyme released from biomass may be aggregated and inactive.

Experimental design

The authors combine excellent and well-thought-out experiments to clarify models to elucidating the role of beta-glucosidase aggregation on cellulolytic enzyme activities.

Validity of the findings

The results and concepts gleaned from this study will be of interest to scientists working in the field of biomass conversion to biofuels.

Comments for the author

This is a carefully planned and performed study. I highly recommend its publication in PeerJ.

Reviewer 2 ·

Basic reporting

This manuscript deals with an important issue in bioprocessing of biomass and provides new things that will certainly find direct application in various areas of this emerging bioconversion sector.

Experimental design

The experimental design was very well outlined.

Validity of the findings

the results have been throughly validated.

Comments for the author

This manuscript deals with an important issue in bioprocessing of biomass and provides new things that will certainly find direct application in various areas of this emerging bioconversion sector.

All text and materials provided via this peer-review history page are made available under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.