TY - JOUR UR - https://doi.org/10.7717/peerj.3252 DO - 10.7717/peerj.3252 TI - Octahedral ruthenium (II) polypyridyl complexes as antimicrobial agents against mycobacterium AU - Liao,Guojian AU - Ye,Zhengyuan AU - Liu,Yunlu AU - Fu,Bin AU - Fu,Chen A2 - Wang,Xiaohui DA - 2017/04/27 PY - 2017 KW - Ruthenium(II) complexes KW - Reactive oxygen species KW - Antibacterial activity AB - Tuberculosis is one of the world’s deadliest infectious disease with 1.5 millions deaths annually. It is imperative to discover novel compounds with potent activity against M. tuberculosis. In this study, susceptibilities of M. smegmatis to the octahedral ruthenium(II) polypyridyl complexes, 1 {[(bpy)3Ru] (PF6)2 (bpy = 2,2′-bipyridine)}, 2 {[(phen)2Ru(dppz)](PF6)2 (phen = 1,10-phenanthroline, dppz = dipyridophenazine)} and 3 {[(phen)3Ru](PF6)2} were measured by broth microdilution and reported as the MIC values. Toxicities of complex 3 to LO2 and hepG2 cell lines were also measured. Complex 2 inhibited the growth of M. smegmatis with MIC value of 2 µg/mL, while complex 3 was bactericidal with MIC value of 26 µg/mL. Furthermore, the bactericidal activity of complex 3 was dependent on reactive oxygen species production. Complex 3 showed no cytotoxicity against LO2 and hepG2 cell lines at concentration as high as 64 µg/mL, paving the way for further optimization and development as a novel antibacterial agent for the treatment of M. tuberculosis infection. VL - 5 SP - e3252 T2 - PeerJ JO - PeerJ J2 - PeerJ SN - 2167-8359 ER -