Review History


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Summary

  • The initial submission of this article was received on November 13th, 2012 and was peer-reviewed by 2 reviewers and the Academic Editor.
  • The article was Accepted by the Academic Editor on December 3rd, 2012.

Version 0.1 (accepted)

·

Basic reporting

The descriptions of the experimental findings are excellent.

Experimental design

Standards of experimental design are high.

Validity of the findings

Findings appear robust, statistically sound, and controlled.

Comments for the author

This is an excellent, focused paper on the ability of short-term potentiation (STP), but not LTP, to modulate the frequency response of bursts of high-frequency synaptic transmission. Because much information in the hippocampus in vivo may be transmitted by high-frequency bursts of pyramidal cell activity, this specific property of STP may be highly relevant to short and intermediate forms of memory. The paper is well-performed and described. One minor rhetorical issue in the Discussion is that I wonder whether STP is really an “extreme example” of the Heisenberg Uncertainty Principle. Testing does affect STP strength, as the authors have previously shown and reproduced here, but in a predictable, not in a random way.

Reviewer 2 ·

Basic reporting

Excellent modeling and fundamental in the field.

Experimental design

with very high sophistication

Validity of the findings

solid

Comments for the author

Excellent modeling in the synaptic plasticity

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