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The descriptions of the experimental findings are excellent.
Standards of experimental design are high.
Findings appear robust, statistically sound, and controlled.
This is an excellent, focused paper on the ability of short-term potentiation (STP), but not LTP, to modulate the frequency response of bursts of high-frequency synaptic transmission. Because much information in the hippocampus in vivo may be transmitted by high-frequency bursts of pyramidal cell activity, this specific property of STP may be highly relevant to short and intermediate forms of memory. The paper is well-performed and described. One minor rhetorical issue in the Discussion is that I wonder whether STP is really an “extreme example” of the Heisenberg Uncertainty Principle. Testing does affect STP strength, as the authors have previously shown and reproduced here, but in a predictable, not in a random way.
Excellent modeling and fundamental in the field.
with very high sophistication
Excellent modeling in the synaptic plasticity
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