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Your manuscript is accepted in PeerJ!
[# PeerJ Staff Note - this decision was reviewed and approved by Valeria Souza, a PeerJ Section Editor covering this Section #]
no comment
no comment
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satisfactory revision
satisfactory revision
satisfactory revision
Please consider and attend to all the comments by the reviewers, and submit a revised version along with a detailed point-by-point letter addressing all the reviews.
Dear authors, the revised manuscript is interesting; however, it is necessary to address the following comments:
Most important comments
Line 158: It is essential that all reagents used in the Materials and Methods section appear in this section, along with their origin. Additionally, each time a reagent is mentioned, include its respective abbreviation, and use this abbreviation in subsequent sections where appropriate.
Line 166: Is it possible to include the corresponding reference to this procedure, or is it a recent development?
Line 181,228: Is it possible to include the corresponding reference to this procedure.
Line 272-273: The information on the origin of the reagents and materials must be included in the first section of the materials and methods section.
Line 310: It is important that the information in the article be presented in an orderly manner. For example, when the procedures are described in the methodology section, the order of appearance must usually be respected later in the results or results and discussion section.
Line 381-383: It is important that no information is discussed in the results section; it should only be mentioned in its respective section.
Line 448: It is important to use abbreviations correctly. If they are mentioned in the text, they should be used throughout the document. Furthermore, if abbreviations for treatments are mentioned in any section, only the abbreviation should be used in the text and its meaning should not be repeated.
Note: It is recommended to carefully review the references section and standardize the format.
Note: Figure 4, it is recommended to add the lists that indicate significant differences.
Note: Figure 4, what are the units in which the results are expressed?
Next most important comments
Line 79: Did you mean CHX? It is important when using an abbreviation to use it throughout the document, from the first time it is mentioned in the text.
Line 81: What is the meaning of MCC?
Line 85: What is the meaning of CS-NPs?
Line 161: Could you indicate what time of year the samples were collected? And add information about the weather conditions during that period?
Line 164: What is the meaning of DMSO?
Line 201: What do you mean by vigorous shaking (xxx rpm, min time?)
Line 204: Use min instead of minutes through the manuscript.
Line 211: Use h instead of h through the manuscript.
Line 213: Add the centrifugation conditions (rpm or x g, time, and temperature)
Line 214: If the abbreviation was previously mentioned, it is not required to indicate its meaning again in the text.
Line 218,259,285: Add text spaces where required.
Line 278: Rewrite… 0.039-5%
Line 295: Add the temperature used during centrifugation process.
Line 314: Rewrite… (a-k)
Line 344: Did you mean CS?
Line 364: Rewrite… (C1-C11)
Line 588: >80% or > 80% like in the abstract; homogenize the text format.
Note: In the materials and methods section, it is important to include information about the equipment used in the procedures mentioned (model, brand, country).
Note: Remove italic text formatting for parentheses ( ) throughout the document, except for its content.
Note: The information contained in the figures sometimes uses uppercase or lowercase letters, or in parentheses or without parentheses to indicate information (a), (b), (c), A, B, C, etc. However, it is recommended to standardize the format.
Note: Table 1, at the bottom of the table use italic text format for scientific names
Note: Table titles sometimes use a period or colon to start the title, for example, Table 1 or Table 2: which is correct?
Least important comments
Line 100: What is the reason for using the abbreviation GAE, if it is not subsequently used in the document?
Line 211: Did you mean 15.11 g?
Some of the procedures are not described in sufficient detail, so it is recommended to review the previous section in more detail.
It is recommended to use literals to establish significant differences in the figures.
There are no comments for this section.
No comment
Encapsulation of molecular weight-variant propolis and CHX into CS-NPs
• How was the molecular weight of the propolis samples calculated?
• What is the concentration of propolis extract in ethanol? And what is the concentration of CS-NPs in water?
• How was CHX added to the CS-NPs? The procedure is not clearly mentioned. (The solvent? Concentration? Incubation duration?)
• For calculation of EE, how was the amount of encapsulated propolis and CHX in CS-NPs measured? There is no explanation!
Transmission electron microscopy (TEM) analysis of chitosan nanoparticles
• As is claimed in the text: “After encapsulation, the chitosan nanoparticles' surface morphology and structural characteristics were examined using Transmission electron microscopy (TEM)”
TEM does not provide the surface morphology of Nps.
pH-responsive drug release kinetics of propolis-loaded chitosan nanoparticles
• Were NPs directly dispersed in release medium (phosphate buffer)?
• At the time of sampling, how were the particles separated from release medium?
• Did the separated particles return to the medium for the rest of release test?
• Was the release of propolis and CHX measured separately?
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