TY - JOUR UR - https://doi.org/10.7717/peerj.2012 DO - 10.7717/peerj.2012 TI - Comparative analysis of prophage-like elements in Helicobacter sp. genomes AU - Fan,Xiangyu AU - Li,Yumei AU - He,Rong AU - Li,Qiang AU - He,Wenxing A2 - Francino,M. Pilar DA - 2016/05/05 PY - 2016 KW - Helicobacter KW - Prophage KW - Phylogeny KW - Comparative genomics AB - Prophages are regarded as one of the factors underlying bacterial virulence, genomic diversification, and fitness, and are ubiquitous in bacterial genomes. Information on Helicobacter sp. prophages remains scarce. In this study, sixteen prophages were identified and analyzed in detail. Eight of them are described for the first time. Based on a comparative genomic analysis, these sixteen prophages can be classified into four different clusters. Phylogenetic relationships of Cluster A Helicobacter prophages were investigated. Furthermore, genomes of Helicobacter prophages from Clusters B, C, and D were analyzed. Interestingly, some putative antibiotic resistance proteins and virulence factors were associated with Helicobacter prophages. VL - 4 SP - e2012 T2 - PeerJ JO - PeerJ J2 - PeerJ SN - 2167-8359 ER -