Review History


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Summary

  • The initial submission of this article was received on January 20th, 2025 and was peer-reviewed by 3 reviewers and the Academic Editor.
  • The Academic Editor made their initial decision on April 24th, 2025.
  • The first revision was submitted on May 6th, 2025 and was reviewed by 2 reviewers and the Academic Editor.
  • The article was Accepted by the Academic Editor on July 8th, 2025.

Version 0.2 (accepted)

· Jul 8, 2025 · Academic Editor

Accept

Thank you for addressing the reviewer comments, which has improved your manuscript. This is now ready for publication. Congratulations.

[# PeerJ Staff Note - this decision was reviewed and approved by Stefano Menini, a PeerJ Section Editor covering this Section #]

Reviewer 2 ·

Basic reporting

The responses and changes are adequate for publication

Experimental design

n/a

Validity of the findings

n/a

·

Basic reporting

fine.

Experimental design

well design

Validity of the findings

quite valuable

Additional comments

no any comment.

Version 0.1 (original submission)

· Apr 24, 2025 · Academic Editor

Minor Revisions

**PeerJ Staff Note:** Please ensure that all review, editorial, and staff comments are addressed in a response letter and that any edits or clarifications mentioned in the letter are also inserted into the revised manuscript where appropriate.

Reviewer 1 ·

Basic reporting

Sometimes it can be difficult to follow along with.

Experimental design

Overall good review of factors affecting hypocalcemia after TT. I would suggest reviewing more articles or expanding on the current review, as it is a bit short. Consider merging the PTH section and the PT gland section

Validity of the findings

Evidence only seems to show significant links to PTH levels s/p TT as it relates to hypocalcemia.
In your rationale/conclusions, you have to make the argument why figuring out another risk factor for hypocalcemia is relevant (are you arguing for more robust/earlier detection of hypocalcemia, cheaper methods than PTH measurements, etc). Since PTH measurements give us a pretty good idea of the risk of post-op hypocalcemia, you need to make a final determination/rationale on why this specific study matters.

Reviewer 2 ·

Basic reporting

-

Experimental design

-

Validity of the findings

-

Additional comments

This narrative review covers the incidence and prevalence of hypocalcemia following thyroidectomy, focusing on patient-related and perioperative risk factors that may predict post-operative hypocalcemia. The background is detailed with relevant citations, and the language is clear and succinct. This is not a meta-analysis or systematic review, but rather a limited review of two databases, including PubMed.

The review primarily includes recent literature from PubMed and a Chinese database. There is no meta-analysis, and the selection of studies from these databases is somewhat arbitrary and not well defined. Authors should elaborate on the selection criteria for the included papers, as not all published studies were chosen.

Given the inclusion of a Chinese database, authors must address potential bias and the limited generalizability of the data. Nonetheless, the review provides a sound overview of the literature on risk factors for hypocalcemia post-thyroidectomy.

·

Basic reporting

-

Experimental design

-

Validity of the findings

-

Additional comments

Good review!
Some faults:
1) Define the term “Hypocalcemia” and subclinical hypocalcemia.
2) Review more about Post-TT hypocalcemia for Graves’ disease.
3) The management of parathyroid venous congestion

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