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Thank you for your efforts to address the reviewer comments. Your manuscript has been reviewed and is now suitable for publication.
[# PeerJ Staff Note - this decision was reviewed and approved by Vladimir Uversky, a PeerJ Section Editor covering this Section #]
No comments.
Comments have been addressed.
Comments have been addressed.
I have no further comments.
no further comments
no further comments
no further comments
no further comments
**PeerJ Staff Note:** Please ensure that all review and editorial comments are addressed in a response letter and that any edits or clarifications mentioned in the letter are also inserted into the revised manuscript where appropriate.
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Sufficient background information is given.
The experimental design is appropriate, one information should be clarified (see additional comments).
Findings are valid.
Based on the evaluation of BMI and various blood parameters obtained from patients with papillary thyroid cancer and healthy controls, the study describes that elevated TG and declined HDL-C were related to increased PTC risk. The study is well conducted and methods and data well described.
Did the females take any hormonal contraceptives that will influence their lipid profiles?
What is the explanation that the OR for TCH is present only in males?
L.118: the description “larger patients” is not clear.
Several sentences are excessively long, which may impede readability. I recommend using an AI-based editing tool or a professional language improvement service to enhance clarity and flow.
No further comments
No further comment
No turther comment
The current study investigated the relationship between serum lipids and papillary thyroid cancer. Overall, the manuscript is well-designed and holds significant clinical relevance. Here are my comments:
Major Comments:
1. Language. Several sentences are excessively long, which may impede readability. I recommend using an AI-based editing tool or a professional language improvement service to enhance clarity and flow.
Minor Comments:
1. Introduction. Revise the sentence: “Results showed that elevated TG and declined HDL-C were related to increased PTC risk among Chinese of both sexes, which may contribute to further investigation concerning diagnosing and preventing this most common type of thyroid cancer.” to: “The study could contribute to further investigation into diagnosing and preventing papillary thyroid cancer, the most common type of thyroid cancer.”
2. Methods. Change the sentence: “we allocated an alias to data immediately after export” to: “Anonymization was conducted prior to further analysis.”, assuming this accurately reflects the intended meaning.
3. Methods. Please ensure that “chi” in “chi-square test” and “t” in “t test” are italicized in accordance with standard scientific notation.
4. Figure. Clarify whether the lines in Figure 1 represent 95% confidence intervals (95% CI), standard error of the mean (SEM), or standard deviation (SD).
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