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All the comments were addressed.
**PeerJ Staff Note:** Although the Academic Editor is happy to accept your article as being scientifically sound, a final check of the manuscript shows that it would benefit from further English editing. Therefore, please identify necessary edits and address these while in proof stage.
The revised manuscript titled “The impacts of vitamin D supplementation on serum levels of thyroid autoantibodies in patients with autoimmune thyroid disease: a meta-analysis” was a meta-analysis study to clarify the alterations in the serum levels of TPOAb and TgAb in the AITD patients following VitD intervention. In this study, the authors conducted a though comprehensive literature search of PubMed, EMBASE, Web of Science, and Cochrane Library databases and finally enclosed 10 studies. After information extraction and synthesis, they found that after VitD administration serum TPOAb and TgAb titers were significantly reduced. The subgroup analysis is reasonable with detailed content and reliable conclusion. The results of this meta-analysis can provide evidence on whether vitamin D supplementation is necessary of AITD and help making clinical treatment decisions.
All the comments raised before have been properly revised or explained.
no comment
no comment
Line133-134 ...forest plots were created to visually reflect the heterogeneity degree among those studies included. This statement is not correct. The forest plot is a comprehensive display of the results of meta-analysis，NOT “reflect the heterogeneity degree among those studies”
The authors have addressed all comments and suggestions well. But now it needs a very profound proofreading to make it suitable for publication at PeerJ
The authors have addressed all comments and suggestions well. But now it needs a very profound proofreading to make it suitable for publication at PeerJ
The authors have addressed all comments and suggestions well. But now it needs a very profound proofreading to make it suitable for publication at PeerJ
Please respond to the reviewers' point by point.
**PeerJ Staff Note:** Please ensure that all review, editorial, and staff comments are addressed in a response letter and that any edits or clarifications mentioned in the letter are also inserted into the revised manuscript where appropriate.
The manuscript titled “The impacts of vitamin D supplementation on serum levels of thyroid autoantibodies in patients with autoimmune thyroid disease: a meta-analysis” was a meta-analysis study to clarify the alterations in the serum levels of TPOAb and TgAb in the AITD patients following VitD intervention. In this study, the authors conducted a thorough comprehensive literature search of PubMed, EMBASE, Web of Science, and Cochrane Library databases and finally enclosed 10 studies. After information extraction and synthesis, they found that after VitD administration serum TPOAb and TgAb titers were significantly reduced. The subgroup analysis is reasonable with detailed content and a reliable conclusion. The writing language of the manuscript is smooth and easy to understand, and the expression is clear. The results of this meta-analysis can provide evidence on whether vitamin D supplementation is necessary for AITD and helps in making clinical treatment decisions.
The following issues still need to be mentioned:
1. Regarding the SEARCH STRATEGY (Line 84-95）, The specific search strategies expressed are not correct。 It should be like: ”(…OR…OR…) AND (…OR…OR…)”, the authors should pay attention to the item between “AND” and “OR”, parentheses cannot be omitted.
2. The resolution of all the Figures (FIG. 1-7) does not meet the requirements, and it is very difficult to see the contents of the pictures clearly
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This manuscript deals with an interesting topic related to vitamin D supplementation and AITD patients. It has a fair level of background and context, and the text is well-written.
However, the authors provide a group of images with inferior quality; thus, this manuscript must be improved before its publication at PeerJ.
This manuscript has a well-defined research question and also is relevant and meaningful. However, the authors need to describe their methods with enough detail and information to replicate their statistical analysis, then the manuscript needs to be improved.
The conclusion of this manuscript is well-stated and linked to the original research question.
Detailed comments and suggestions are in the attached file; please revise them. I will be honored to revise the revised version of this manuscript.
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