All reviews of published articles are made public. This includes manuscript files, peer review comments, author rebuttals and revised materials. Note: This was optional for articles submitted before 13 February 2023.
Peer reviewers are encouraged (but not required) to provide their names to the authors when submitting their peer review. If they agree to provide their name, then their personal profile page will reflect a public acknowledgment that they performed a review (even if the article is rejected). If the article is accepted, then reviewers who provided their name will be associated with the article itself.
Thank you for addressing the comments from the reviewers.
[# PeerJ Staff Note - this decision was reviewed and approved by Vladimir Uversky, a PeerJ Section Editor covering this Section #]
no comment
no comment
no comment
no comment
The revisions have successfully addressed the reviewers' concerns.
I recommend that PeerJ accept the manuscript for publication.
The revisions have successfully addressed the reviewers' concerns.
I recommend that PeerJ accept the manuscript for publication.
The revisions have successfully addressed the reviewers' concerns.
I recommend that PeerJ accept the manuscript for publication.
The revisions have successfully addressed the reviewers' concerns.
I recommend that PeerJ accept the manuscript for publication.
This is an interesting and relevant article. Please address the reviewer's comments and resubmit the revised manuscript.
See below
See below
See below
This paper reviews the relationship between the MAPK 73 signaling pathways and osteogenic differentiation of PDLSCs, summarizes the currently known 74 relevant factors that affect the osteogenic differentiation of PDLSCs by activating the MAPK 75 signaling pathways, and provides research ideas for the better application of PDLSCs in 76 periodontal tissue regeneration. I think you will find this review very interesting. We suggest adding more information for 1.1, 1.2, 1.3, and 1.4. in Biological effects of the MAPK signaling pathways section.
The manuscript is well-written and follows a clear structure, but it would benefit from updated references to include recent studies. Figures and tables are informative but could use better labeling and detailed legends for clarity. Adding a summary table or schematic diagram would help present complex data more effectively. Overall, the content is relevant and provides valuable insights into MAPK signaling and osteogenesis.
The study design is appropriate for a review article, with a clear focus on MAPK signaling pathways and their role in osteogenesis. However, the methodology for selecting and analyzing studies is not sufficiently detailed. Providing explicit inclusion and exclusion criteria for the reviewed literature would enhance transparency and reproducibility. Additionally, integrating a comparative analysis of MAPK signaling with other related pathways would strengthen the review's impact.
The findings in the manuscript are valid and supported by the cited literature. However, the review would benefit from including more recent studies to ensure the conclusions are up-to-date. The analysis of MAPK signaling pathways is thorough, but some key gaps, such as potential adverse effects or limitations of therapeutic applications, need to be addressed to provide a balanced perspective. Overall, the findings are credible but could be strengthened with additional critical analysis and integration of newer evidence.
No
All text and materials provided via this peer-review history page are made available under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.