All reviews of published articles are made public. This includes manuscript files, peer review comments, author rebuttals and revised materials. Note: This was optional for articles submitted before 13 February 2023.
Peer reviewers are encouraged (but not required) to provide their names to the authors when submitting their peer review. If they agree to provide their name, then their personal profile page will reflect a public acknowledgment that they performed a review (even if the article is rejected). If the article is accepted, then reviewers who provided their name will be associated with the article itself.
Dear Authors,
Thank you for your revisions. After carefully reviewing your responses, I am pleased to inform you that you have successfully addressed all of the reviewers' comments. Therefore, the manuscript titled "Differences in cardiovascular disease mortality between northern and southern China under exposure to different temperatures: A systematic review" has been accepted for publication in PeerJ.
Congratulations on your work, and we look forward to seeing your paper published.
Best regards,
Dr. Pedrino
[# PeerJ Staff Note - this decision was reviewed and approved by Celine Gallagher, a PeerJ Section Editor covering this Section #]
No comment.
No comment.
No comment.
No comment.
The pathophysiological linkage between weather conditions (including extreme temperatures), CV health and acute CV diseases are now better explicited in the Introduction and some examples are now available.
No further comments.
No further comments.
No further comments.
Both reviewers have provided clear suggestions for you to address. Please be sure to respond to all their comments.
[# PeerJ Staff Note: It is PeerJ policy that additional references suggested during the peer-review process should *only* be included if the authors are in agreement that they are relevant and useful #]
[# PeerJ Staff Note: PeerJ can provide language editing services if you wish - please contact us at [email protected] for pricing (be sure to provide your manuscript number and title). Your revision deadline is always extended while you undergo language editing. #]
The systematic review and meta-analysis provide a thorough examination of the impact of temperature on cardiovascular disease (CVD) mortality across various regions in China. By stratifying the analysis into extreme cold, extreme heat, and diurnal temperature range (DTR), the study offers valuable insights into regional variations in vulnerability to temperature extremes.
The study adheres to PRISMA guidelines and employs robust statistical methods such as random effects models, sensitivity analysis, and subgroup analysis by region. This approach enhances the reliability and validity of the findings, despite the observed heterogeneity across studies.
Findings highlight the urgent need for tailored public health policies to mitigate the adverse effects of temperature extremes on CVD mortality in different regions of China. The identification of differential susceptibilities between northern and southern regions underscores the importance of localized interventions.
How do the findings of this meta-analysis translate to rural areas where access to healthcare resources and adaptation strategies to temperature extremes might differ significantly from urban settings?
Considering the increasing burden of CVD globally, how might climate change influence future trends in CVD mortality associated with temperature extremes in China?
Given that low and middle-income countries bear a disproportionate burden of CVD mortality, how can the findings of this study inform international efforts to address climate-related health disparities beyond China's borders?
Your introduction provides an accurate overview of the context and the public health issue; literature is well referenced and relevant. However, although you reported that exposure to extreme environmental temperatures do contribute to increase in cardiovascular (CV) mortality, how these weather conditions may affect CV health is not clearly specified in the Introduction, but only briefly referred in the Discussion.
Therefore, I suggest to further explicit the pathophysiological linkage between weather conditions (including extreme temperatures), CV health and acute CV diseases in the text, eventually providing some examples.
The paper provides a well-defined research question, with clinical relevance in public health and daily clinical practice. It is clearly stated how the research fills an identified knowledge gap.
A rigorous investigation was performed and methods are described with sufficient detail and information to replicate.
All underlying data have been provided; they are robust, statistically sound and controlled.
Limitations of the study are clearly exposed and their implication on results are critically analysed.
Conclusions are well stated, linked to original research question and limited to supporting results.
Your introduction provides an accurate overview of the context and the public health issue; literature is well referenced and relevant. However, although you reported that exposure to extreme environmental temperatures do contribute to increase in cardiovascular (CV) mortality, how these weather conditions may affect CV health is not clearly specified in the Introduction.
I suggest you a recent review by De Vita et al. (J. Clin. Med. 2024, 13, 759. DOI: 10.3390/jcm13030759), which provides an exhaustive compendium about current evidences in the linkage between weather conditions (including extreme temperatures), CV health and acute CV diseases. Therefore, I suggest to further explicit this pathophysiological linkage in the text, eventually providing some examples.
All text and materials provided via this peer-review history page are made available under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.