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I request that the authors update the abstract conclusions in the final proof to reflect what the reviewer has requested. And, congratulations on your article's acceptance!
[# PeerJ Staff Note - this decision was reviewed and approved by Jafri Abdullah, a PeerJ Section Editor covering this Section #]
Minor revision:
The “Conclusion” in the Abstract is not accurate and in its current form is basically just “future direction. I reccommend the authors to paraphrase it to something similar to lines 261-265.
No comments
No comments
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The authors have included statements in the manuscript according to the reviewers' suggestion.
No comment
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Please address the reviewer's comments for minor revisions.
[# PeerJ Staff Note: Please ensure that all review and editorial comments are addressed in a response letter and any edits or clarifications mentioned in the letter are also inserted into the revised manuscript where appropriate. #]
The manuscript is clearly written with adequate background and references.
The authors identify different bacterial infections from the CSF of patients and attempts to find its correlation to established measures of immune inflammation, I.e., NLR, PLR, SII, etc.
The authors claim through adequate background that the correlation between these parameters are studied in the context of tumors, but the same in infection is lacking.
Finding this correlation will help treat patients facing CSF infections before the bacterial culture results are made available.
Minor concerns:
the study is reporting measures of multiple different parameters, but the reasoning for choosing said parameter are not well justified. I recommend removing parameters in the “variables” column of table 1 and 2 that show non-significant p-value.
The authors show that the patients with gram negative bacteria and the CoNS gram positive bacterial infections show lower SII than non-Co-NS infected patients (Table 2).
They also show reduced SII during treatment in comparison to patients with mortality for gram-negative and Co-NS infected patients (Table 4)
Minor revision:
A) Hu, B., et. Al, 2014 clinical cancer research paper that defined SII in HCC used x-tile analysis to determine that SII>300 x 10(9) is poor prognosis for HCC patients. I recommend the authors to try a similar approach for each bacterial group to determine the SII value that could mean increased CSF infection.
B) Although there are both positive and negative correlations reported between SII and clinical parameters in table 5, the strongest correlation is observed only in neutrophil level and antibiotic revision. While the weak correlation of SII were with CSF glucose, lymphocyte, eosinophil, platelet and mortality. Rest of the parameters in Table 5 show moderate correlation. I recommend the authors to correct the last paragraph of the results section accordingly, as in the current form it is very misleading.
Interesting work with potential.
The authors have provided adequate literature references. The structure of the paper is defined.
The limitation of the paper is the number of samples analyzed. Please include it as a limitation of the study in discussion section.
The validity of the findings is not assessed.
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