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2025
Protein kinase D1 mitigation against etoposide induced DNA damage in prostate cancer is associated with increased α‐Catenin
The Prostate
2024
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland
European Journal of Medicinal Chemistry
2024
Kinase inhibitor pulldown assay (KiP) for clinical proteomics
Clinical Proteomics
2023
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
MedComm
2023
Navigating the ERK1/2 MAPK Cascade
Biomolecules
2023
Proteomic and phosphoproteomic characteristics of the cortex, hippocampus, thalamus, lung, and kidney in COVID-19-infected female K18-hACE2 mice
eBioMedicine
2023
The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants
Human Genomics
2022
Phosphoproteome profiling of mouse liver during normal aging
Proteome Science
2022
Structure-based design of small molecule and peptide inhibitors for selective targeting of ROCK1: an integrative computational approach
Journal of Biomolecular Structure and Dynamics
2021
ProfKin: A comprehensive web server for structure-based kinase profiling
European Journal of Medicinal Chemistry
2021
Improved potency of pyridin-2(1H)one derivatives for the treatment of mechanical allodynia
European Journal of Medicinal Chemistry
2021
Mobocertinib (TAK-788): A Targeted Inhibitor ofEGFRExon 20 Insertion Mutants in Non–Small Cell Lung Cancer
Cancer Discovery
2021
High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy
Scientific Reports
2020
Evolution of new enzymes by gene duplication and divergence
The FEBS Journal
2020
Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia
European Journal of Medicinal Chemistry
2020
Prevalence and significance of the commonest phosphorylated motifs in the human proteome: a global analysis
Cellular and Molecular Life Sciences
2020
Novel method to identify group-specific non-catalytic pockets of human kinome for drug design
RSC Advances
2020
Discovery of a novel kinase hinge binder fragment by dynamic undocking
RSC Medicinal Chemistry
2020
An electrophilic warhead library for mapping the reactivity and accessibility of tractable cysteines in protein kinases
European Journal of Medicinal Chemistry
2020
Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types
Journal of Medicinal Chemistry
2020
Revealing the Unbinding Kinetics and Mechanism of Type I and Type II Protein Kinase Inhibitors by Local-Scaled Molecular Dynamics Simulations
Journal of Chemical Theory and Computation
2020
Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker
Clinical Cancer Research
2020
KinomeRun: An interactive utility for kinome target screening and interaction fingerprint analysis towards holistic visualization on kinome tree
Chemical Biology & Drug Design
2019
Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability*
Molecular & Cellular Proteomics
2019
KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules
Bioinformatics
2019
CoralP: Flexible visualization of the human phosphatome
Journal of Open Source Software
2019
A Structurally-Validated Multiple Sequence Alignment of 497 Human Protein Kinase Domains
Scientific Reports
2019
A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia
Molecular Cancer Therapeutics
2019
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
Nature Communications
2019
Investigation of Crystal Structures in Structure-Based Virtual Screening for Protein Kinase Inhibitors
Journal of Chemical Information and Modeling
2019
HKPocket: human kinase pocket database for drug design
BMC Bioinformatics
2019
Methods in Molecular Biology
2018
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Cell
2018
Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer
Journal of Medicinal Chemistry
2018
Comprehensive assessment of nine docking programs on type II kinase inhibitors: prediction accuracy of sampling power, scoring power and screening power
Briefings in Bioinformatics
2018
Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition
Bioorganic & Medicinal Chemistry
2018
Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia
Journal of Medicinal Chemistry
2018
Coral: Clear and Customizable Visualization of Human Kinome Data
Cell Systems
2018
Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors
Bioorganic & Medicinal Chemistry Letters
2018
Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines
Journal of Medicinal Chemistry
2018
Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer
Journal of Medicinal Chemistry
2018
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression
Scientific Reports
2018
Exploring Selectivity of Multikinase Inhibitors across the Human Kinome
ACS Omega
2018
Design, synthesis and evaluation of (R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor
MedChemComm
2017
Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
2017
C-SPADE: a web-tool for interactive analysis and visualization of drug screening experiments through compound-specific bioactivity dendrograms
Nucleic Acids Research
2017
Mapping of inhibitors and activity data to the human kinome and exploring promiscuity from a ligand and target perspective
Chemical Biology & Drug Design
2017
Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
Data in Brief
2017
Annual Reports in Medicinal Chemistry
2017
Methods and Principles in Medicinal Chemistry
2017
Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy
Scientific Reports
2017
One Drug for Multiple Targets: A Computational Perspective
Journal of the Mexican Chemical Society
2017
Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance
Journal of Chemical Information and Modeling
2017
Nuclear phosphoproteome analysis of 3T3‐L1 preadipocyte differentiation reveals system‐wide phosphorylation of transcriptional regulators
PROTEOMICS
2017
Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype
Laboratory Investigation
2017
Identifying pathogenicity of human variants via paralog-based yeast complementation
PLOS Genetics
2017
KinMap: a web-based tool for interactive navigation through human kinome data
BMC Bioinformatics
2016
Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition
Journal of Proteomics
2016
Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib
Oncotarget
2016
Activity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer
Proteomes
2016
Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors
Bioorganic & Medicinal Chemistry
2016
Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition
Journal of Proteome Research
2016
The kinome 'at large' in cancer
Nature Reviews Cancer
2016
KLIFS: a structural kinase-ligand interaction database
Nucleic Acids Research
2016
Systems biological understanding of the regulatory network and the possible therapeutic strategies for vascular calcification
Molecular BioSystems
2016
Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound–Kinase Activities: A Way toward Selective Promiscuity by Design?
Journal of Chemical Information and Modeling
2016
AAPS Advances in the Pharmaceutical Sciences Series
2016
From Lead to Drug Candidate: Optimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as Agents for the Treatment of Triple Negative Breast Cancer
Journal of Medicinal Chemistry
2015
Detection of Binding Site Molecular Interaction Field Similarities
Journal of Chemical Information and Modeling
2015
Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis
Bioorganic & Medicinal Chemistry
2015
Kovalent‐allosterische Kinase‐Inhibitoren
Angewandte Chemie
2015
Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ
Scientific Reports
2015
Covalent‐Allosteric Kinase Inhibitors
Angewandte Chemie International Edition
2015
Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics
PROTEOMICS
2015
Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors
Journal of Medicinal Chemistry
2015
DFGmodel: Predicting Protein Kinase Structures in Inactive States for Structure-Based Discovery of Type-II Inhibitors
ACS Chemical Biology
2015
The Nuclear Proteome of a Vertebrate
Current Biology
2014
Роль селективности ингибиторов тирозинкиназ в развитии побочных эффектов при терапии хронического миелолейкоза
Clinical Oncohematology
2014
A novel small-molecule MRCK inhibitor blocks cancer cell invasion
Cell Communication and Signaling
2014
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Nature Genetics
2014
Assessing adaptation of the cancer kinome in response to targeted therapies
Biochemical Society Transactions
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