Review History


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Summary

  • The initial submission of this article was received on June 18th, 2015 and was peer-reviewed by 2 reviewers and the Academic Editor.
  • The Academic Editor made their initial decision on July 31st, 2015.
  • The first revision was submitted on August 5th, 2015 and was reviewed by 2 reviewers and the Academic Editor.
  • The article was Accepted by the Academic Editor on August 21st, 2015.

Version 0.2 (accepted)

· · Academic Editor

Accept

The manuscript has scientific merit and all the comments of the reviewers have been assessed correctly; therefore It is a distinct pleasure to inform you that your manuscript has been accepted for publication in PeerJ.

·

Basic reporting

No comments

Experimental design

No comments

Validity of the findings

No comments

Comments for the author

I believe that the author has taken into consideration the suggestions made by both referees and has improved the overall quality of the article. I deem that the article should be accepted as is.

·

Basic reporting

The author has properly addressed and revised the manuscript as advised in the previous review round. The manuscript has been significantly improved and therefore I believe it is now ready to be published.

Experimental design

Experimental design is OK

Validity of the findings

Validity of the findings is OK

Version 0.1 (original submission)

· · Academic Editor

Minor Revisions

Dear authors:

Thank you for submitting your manuscript for review to PeerJ. After careful consideration, we feel that your manuscript will likely be suitable for publication if it is revised to address the points below. Therefore, my decision is "Minor Revision."

·

Basic reporting

No comments

Experimental design

No comments

Validity of the findings

No comments

Comments for the author

Overally, it is a well written and well-organized paper that should be taken into consideration for the scientists who conduct meta-analyses of independent studies. Therefore, I suggest to accept this paper after the author has taken into account the following minor comments indicated within the attached PDF file.
I would recommended that the author using passive instead of active voice. Given that it is a single-author paper, the author should better avoid using "we".

·

Basic reporting

This is a comprehensive meta-analysis that combines many independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-alpha) gene, using Bayesian statistics. Herein, it is clear that indeed CHD is not more likely to occur when the SNP is present, which suggests that the -308 TNF-alpha SNP is not implicated in the occurrence of CHD. I believe that this is a very sound scientifically piece of work that deserves to be published.

Experimental design

Experimental design is sound and well laid out. I would suggest that the author of this manuscript adds a flowchart that summarises the whole exp. design of this article.

Validity of the findings

Validity of the findings of this article is sound. Properly calculated and well presented.

Comments for the author

Overall, I would suggest very minor revisions:
1) Figure 2, could go in the appendix
2) Tables iii and iv have been mis-positioned in the review-pdf. Please check
3) Maybe some "popular science" semi-conclusions could be added next to the math sections of the manuscript to aid the reader.

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