TY - JOUR
UR - https://doi.org/10.7717/peerj.1236
DO - 10.7717/peerj.1236
TI - Integrated probability of coronary heart disease subject to the −308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis
AU - Carvalho,C. Sofia
A2 - Palazón-Bru,Antonio
DA - 2015/09/15
PY - 2015
KW - Bayesian meta-analysis
KW - Coronary heart disease
KW - −308 TNF-alpha
AB -
We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the −308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing indicates that there is no preference for the hypothesis that the −308 TNF-alpha SNP is related to the occurrence of CHD, in the Caucasian or in the Asian population, over the null hypothesis. As a measure of correlation, we use the probability of occurrence of CHD conditional on the presence of the SNP, derived as the posterior probability of the Bayesian meta-analysis. The conditional probability indicates that CHD is not more likely to occur when the SNP is present, which suggests that the −308 TNF-alpha SNP is not implicated in the occurrence of CHD.
VL - 3
SP - e1236
T2 - PeerJ
JO - PeerJ
J2 - PeerJ
SN - 2167-8359
ER -