@article{10.7717/peerj.1236,
title = {Integrated probability of coronary heart disease subject to the −308 tumor necrosis factor-alpha SNP: a Bayesian meta-analysis},
author = {Carvalho, C. Sofia},
year = 2015,
month = sep,
keywords = {Bayesian meta-analysis, Coronary heart disease, −308 TNF-alpha},
abstract = {
We present a meta-analysis of independent studies on the potential implication in the occurrence of coronary heart disease (CHD) of the single-nucleotide polymorphism (SNP) at the −308 position of the tumor necrosis factor alpha (TNF-alpha) gene. We use Bayesian analysis to integrate independent data sets and to infer statistically robust measurements of correlation. Bayesian hypothesis testing indicates that there is no preference for the hypothesis that the −308 TNF-alpha SNP is related to the occurrence of CHD, in the Caucasian or in the Asian population, over the null hypothesis. As a measure of correlation, we use the probability of occurrence of CHD conditional on the presence of the SNP, derived as the posterior probability of the Bayesian meta-analysis. The conditional probability indicates that CHD is not more likely to occur when the SNP is present, which suggests that the −308 TNF-alpha SNP is not implicated in the occurrence of CHD.
},
volume = 3,
pages = {e1236},
journal = {PeerJ},
issn = {2167-8359},
url = {https://doi.org/10.7717/peerj.1236},
doi = {10.7717/peerj.1236}
}