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Thank you for addressing all questions. I am glad to accept your paper!
[# PeerJ Staff Note - this decision was reviewed and approved by Vladimir Uversky, a PeerJ Section Editor covering this Section #]
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I have no further comment on the revised manuscript.
Our reviewers are very positive about your study and have some suggestions for the improvement of your manuscript. Please address them thoroughly.
I feel as though the authors mention health problems and inflammation, but don't draw a strong and explicit enough link between increased inflammation and health problems. The reader might find a few citations linking prolonged inflammation to health.
While I do understand and appreciate your use of female mice, it could use a little more explanation, perhaps with some citations. There is some evidence of variation of the inflammatory response across the estrous cycle in mice. Since your mice were P21, were they not yet sexually mature? Do you not expect this to be an issue for your study? Please elaborate.
I suggest removing all mention of trending results from the results section to make the text more clear. Statistical purists will always say that your finding is either significant or not with nothing in between.
A well written and interesting study. I have very little to add.
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The present study determined the inflammatory response to acute and chronic sleep fragmentation and assessed the modulating effects of α- and β- adrenergic receptors antagonists on these responses. Findings of this study added meaningful data about the sympathetic nervous system mechanism of the stress responses resulted from sleep disorders. Advice for the author:
A.Give evidences or reasons for the choice of sampling sites in the central parts and peripheral organs/tissues in the introduction or discussion section.
B. What suggestions for clinical practices could be drawn from this study findings?
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