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No further comments - the comments made by the reviewers have been fully adressed.
Dear Dr. Göllner,
Please answer specifically to the comments of Reviewer 2.
Figure 2: A little more explanation of the output would help. Grey=light blue? Is there a solution for the overprinting of SNP numbers like symbols or colours?
Figure 3: The representation of SNPs as numbers is not so decent. Maybe symbols would give a clearer graphic.
Why is there a threshold of 5% MAF?
Why was D' taken as Linkage Disequilibrium measurement? D' takes not into account if SNPs have different MAFs.
The experimental design fits to the PeerJ standards within the scope of the journal. However, I am not adequately qualified to comment in detail on the statistical methods used on the data.
This manuscript reports on an investigation of selection in the dopamine receptor 2 gene. Please find two comments below:
1. Whilst this reviewer is not an expert in neurology or psychiatry, it has to be asked whether there are any links between directional selection and schizophrenia. Maybe the authors could comment on this question.
2. In 2014, the Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature, 2014; doi:10.1038/nature13595) reported 108 loci to be genome-wide significantly associated with schizophrenia. Being DRD2 one of these loci, the SNPs detected in this study have not been found to be associated. The findings in this study should be discussed in the light of association studies.
3. The manuscript mainly presents data on selection in the DRD2 gene by a bioiformatical approach. The conclusions of the paper should be limited to this finding which ist still interesting.
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