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35 downloads
61 views

We present a fast, validated, open-source toolkit for processing dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data. We validate it against the Quantitative Imaging Biomarkers Alliance (QIBA) Standard and Extended Tofts-Kety phantoms and find near...

["Radiology and Medical Imaging","Computational Science"]
doi:10.7717/peerj.909
58 downloads
137 views

Quantitative analysis of stable isotopes (SI) and, more recently, fatty acid profiles (FAP) are useful and complementary tools for estimating the relative contribution of different prey items in the diet of a predator. The combination of these two approaches, however,...

["Aquaculture, Fisheries and Fish Science","Bioinformatics","Conservation Biology","Ecology"]
doi:10.7717/peerj.920
21 downloads
31 views

Objectives. We wished to determine test re-test reliability and construct validity of the star-track test of manual dexterity.Design. Test re-test reliability was examined in a controlled study. Construct validity was tested in a blinded randomized crossover study.Setting....

["Drugs and Devices","Kinesiology","Surgery and Surgical Specialties","Statistics"]
doi:10.7717/peerj.917
19 downloads
28 views

The literature about possible cardiovascular consequences of diagnostic inertia in diabetes is scarce. We examined the influence of undetected high fasting blood glucose (FBG) levels on the cardiovascular risk and poor control of cardiovascular risk factors in...

["Diabetes and Endocrinology","Epidemiology","Nutrition","Public Health"]
doi:10.7717/peerj.914
17 downloads
70 views

Objective. We compared the precision of a search strategy designed specifically to retrieve randomized controlled trials (RCTs) and systematic reviews of RCTs with search strategies designed for broader purposes.Methods. We designed an experimental search strategy...

["Evidence Based Medicine","Science and Medical Education","Statistics","Computational Science"]
doi:10.7717/peerj.913
18 downloads
56 views

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density. The packing density measure that...

["Biophysics","Computational Biology","Evolutionary Studies","Mathematical Biology"]
doi:10.7717/peerj.911
10 downloads
11 views

To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23) receptor gene and ankylosing spondylitis (AS), a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge...

["Genetics","Orthopedics","Rheumatology","Statistics"]
doi:10.7717/peerj.910
32 downloads
36 views

Results from large multicentre epidemiological studies suggest an association between the consumption of raw milk and a reduced incidence of allergy and asthma in children. Although the underlying mechanisms for this association are yet to be confirmed, researchers...

["Biotechnology","Genetics","Microbiology"]
doi:10.7717/peerj.888
15 downloads
47 views

GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases. CyaB2, an adenylyl cyclase from Anabaena, contains two GAF domains...

["Biochemistry"]
doi:10.7717/peerj.882
20 downloads
19 views

Objectives. This study aimed to investigate the influences of N-acetyl cysteine (NAC) on cytotoxicity and mechanical properties of Poly-methylmethacrylate (PMMA) dental resins.Methods. Experimental PMMA resin was prepared by incorporating various concentrations...

["Dentistry"]
doi:10.7717/peerj.868
93 downloads
491 views

Sex differences in some preferences and motivations are well established, but it is unclear whether they persist in selective sub-populations, such as expert financial decision makers, top scientists, or elite athletes. We addressed this issue by studying competitiveness...

["Anthropology","Kinesiology","Psychiatry and Psychology"]
doi:10.7717/peerj.884
30 downloads
81 views

Background. Previous work has demonstrated that a commercial gaming electroencephalography (EEG) system, Emotiv EPOC, can be adjusted to provide valid auditory event-related potentials (ERPs) in adults that are comparable to ERPs recorded by a research-grade EEG...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.907
74 downloads
383 views

Originally identified as an ornithischian dinosaur, Crosbysaurus harrisae has been found in New Mexico, Arizona, and its type locality in Texas, as well as in North Carolina. The genus has been reassessed by other workers in light of reinterpretations about the...

["Paleontology"]
doi:10.7717/peerj.905
26 downloads
128 views

Comparing inferences among datasets generated using short read sequencing may provide insight into the concerted impacts of divergence, gene flow and selection across organisms, but comparisons are complicated by biases introduced during dataset assembly. Sequence...

["Bioinformatics","Evolutionary Studies","Genetics","Genomics","Molecular Biology"]
doi:10.7717/peerj.895
74 downloads
181 views

The teosinte branched1(tb1) gene is a major QTL controlling branching differences between maize and its wild progenitor, teosinte. The insertion of a transposable element (Hopscotch) upstream of tb1 is known to enhance the gene’s expression, causing reduced tillering...

["Agricultural Science","Ecology","Evolutionary Studies","Genetics"]
doi:10.7717/peerj.900

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