I am an Assistant professor at Department of Biochemistry, State University of New York at Buffalo. I have expertise and extensive experience with developing and applying computational approaches for transcriptional and epigenetics regulation studies. As a postdoctoral fellow at Dana-Farber Cancer Institute, I developed widely used open-source algorithms, including MACS (cited over 3,200 times according to Google Scholar) to analyze ChIP-seq data, and an integrative platform for comprehensive analyses on cis-regulatory elements (http://cistrome.org/ap), which has over 3,000 users. I was a member of the Data Analysis Center and Analysis Working Group of the ENCODE and modENCODE consortium and was involved in deciphering functional elements through analyzing high-throughput profiles of chromatin factors and in comparing chromatin features between fly, worm and human genome. I have actively participated in the development of ChIP-seq guidelines for the broad scientific communities. My laboratory at University at Buffalo is focused on studying transcriptional and epigenetic regulatory mechanisms, and the influence of the genetic variations at regulatory elements.