Professor Ralf Paus researches into the biology and pathology of the hair follicle, skin neuroendocrinology, and the science and applications of stem cells residing in human skin.
Past or current institution affiliations
University of Manchester
Ralf researches into the biology and pathology of the hair follicle as a microcosmic miniorgan in which many of the fundamental problems of biology can be studied exemplarily. Currently, he is most intrigued by the astounding neuroendocrine properties of the human hair follicle, their impact on mitochondrial function and hair follicle immune status, and the use of adult hair follicle stem cells for regenerative medicine purposes. Ralf's particular interest is in: better defining and in manipulating various neuroendocrine pathways established in the human hair follicle (HPA and HPT axis equivalent systems) and in elucidating novel functions of this neuroendocrine activity, such as neuroendocrine controls of mitochondrial activity and biogenesis in human skin, stem cell biology, and wound healing understanding the controls and functions of hair follicle immune privilege and its disorders that lead to alopecia areata or scarring alopecia characterizing, selectively labelling, isolating and differentiating various stem cells populations associated with human scalp skin and its appendages role of clock genes and olfactory receptors in the control of human hair growth and pigmentation Methodologically, Ralf employs mainly human hair follicle and scalp skin organ culture, K15-GFP+ human epithelial hair follicle stem cells, and immunohistology/immunofluorescence, gene expression profiling, and analyzes the hair and skin phenotype of relevant mouse mutants.
February 19, 2013
A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ